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Unlocking same‐sign CPL: solvent effects on spectral form and racemisation kinetics in nine‐coordinate chiral europium(III) complexes (2023)
Journal Article
De Rosa, D. F., Starck, M., Parker, D., & Pal, R. (2023). Unlocking same‐sign CPL: solvent effects on spectral form and racemisation kinetics in nine‐coordinate chiral europium(III) complexes. Chemistry - A European Journal, https://doi.org/10.1002/chem.202303227

Understanding the factors that shape the circularly polarised luminescence (CPL) emission profiles of europium(III)-based CPL emitters to have specific sign properties, e. g. monosignate individual CPL transitions, is key to design novel complexes fo... Read More about Unlocking same‐sign CPL: solvent effects on spectral form and racemisation kinetics in nine‐coordinate chiral europium(III) complexes.

Triggered Functional Dynamics of AsLOV2 by Time‐Resolved Electron Paramagnetic Resonance at High Magnetic Fields (2023)
Journal Article

We present time-resolved Gd−Gd electron paramagnetic resonance (TiGGER) at 240 GHz for tracking inter-residue distances during a protein's mechanical cycle in the solution state. TiGGER makes use of Gd-sTPATCN spin labels, whose favorable qualities i... Read More about Triggered Functional Dynamics of AsLOV2 by Time‐Resolved Electron Paramagnetic Resonance at High Magnetic Fields.

Comparative Analysis of a Series of pH‐Responsive Sulphonated Europium Complexes for Bioassays Monitoring Acidification (2022)
Journal Article

The synthesis and photophysical evaluation of a series of hydrophilic sulphonated and pH responsive luminescent europium(III) probes are reported. The Eu emission intensities and lifetimes increase very significantly on lowering pH, leading to a ‘swi... Read More about Comparative Analysis of a Series of pH‐Responsive Sulphonated Europium Complexes for Bioassays Monitoring Acidification.

Versatile, Cheap, Readily Modifiable Sample Delivery Method for Analysis of Air-/Moisture-Sensitive Samples Using Atmospheric Pressure Solids Analysis Probe Mass Spectrometry (2022)
Journal Article

A cheap, versatile, readily modified, and reusable glass probe system enabling delivery of solid air-/moisture-sensitive samples for mass spectrometric (MS) analysis using an Atmospheric pressure Solids Analysis Probe (ASAP) is described. The simplic... Read More about Versatile, Cheap, Readily Modifiable Sample Delivery Method for Analysis of Air-/Moisture-Sensitive Samples Using Atmospheric Pressure Solids Analysis Probe Mass Spectrometry.

Circularly polarised luminescence laser scanning confocal microscopy to study live cell chiral molecular interactions (2022)
Journal Article

The molecular machinery of life is founded on chiral building blocks, but no experimental technique is currently available to distinguish or monitor chiral systems in live cell bio-imaging studies. Luminescent chiral molecules encode a unique optical... Read More about Circularly polarised luminescence laser scanning confocal microscopy to study live cell chiral molecular interactions.

Versatile Para‐Substituted Pyridine Lanthanide Coordination Complexes Allow Late Stage Tailoring of Complex Function (2021)
Journal Article

A series of cationic and neutral p−Br and p−NO2 pyridine substituted Eu(III) and Gd(III) coordination complexes serve as versatile synthetic intermediates. Nucleophilic aromatic substitution occurs readily at the para position under mild conditions,... Read More about Versatile Para‐Substituted Pyridine Lanthanide Coordination Complexes Allow Late Stage Tailoring of Complex Function.

Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes (2021)
Journal Article

The relative sensitivities of structurally related Eu(III) complexes to quenching by electron and energy transfer processes have been compared. In two sets of 9-coordinate complexes based on 1,4,7-triazacyclononane, the Eu emission lifetime decreased... Read More about Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes.

Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field (2021)
Journal Article

Examination of total emission and circularly polarised luminescence (CPL) spectra of three 9-coordinate Eu(III) complexes with well-defined speciation shows that the ligand fields of these C3 symmetric complexes are extremely sensitive to solvent pol... Read More about Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field.

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging (2021)
Journal Article

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lant... Read More about Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging.

Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells (2020)
Journal Article

A set of four luminescent Eu(III) complexes bearing an extended aryl‐alkynylpyridine chromophore has been studied, showing very different pH‐dependent behaviour in their absorption and emission spectral response. For two complexes with p K a values o... Read More about Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells.

How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior (2020)
Journal Article

Complexes of lanthanide(III) ions are being actively studied because of their unique ground and excited state properties and the associated optical and magnetic behavior. In particular, they are used as emissive probes in optical spectroscopy and mic... Read More about How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior.

Targeted Luminescent Europium Peptide Conjugates: Comparative Analysis Using Maleimide and para-Nitropyridyl Linkages for Organelle Staining (2019)
Journal Article

The syntheses and photophysical behaviour of nine, strongly luminescent nonadentate Eu(III) complexes are reported. Each complex is based on N-functionalised 1,4,7- triazacyclononane, and linkage to other groups or targeting vectors can occur either... Read More about Targeted Luminescent Europium Peptide Conjugates: Comparative Analysis Using Maleimide and para-Nitropyridyl Linkages for Organelle Staining.

Periodic trends and hidden dynamics of magnetic properties in three series of triazacyclononane lanthanide complexes (2019)
Journal Article

In three structurally related series of nine-coordinate lanthanide(III) complexes (Ln = Tb, Dy, Ho, Er, Tm and Yb) based on triazacyclononane, solution NMR studies and DFT/CASSCF calculations have provided key information on the magnetic susceptibili... Read More about Periodic trends and hidden dynamics of magnetic properties in three series of triazacyclononane lanthanide complexes.

Unravelling the Complexities of Pseudocontact Shift Analysis in Lanthanide Coordination Complexes of Differing Symmetry (2019)
Journal Article
Parker, D., Suturina, E., Harnden, A., Batsanov, A., Fox, M., Mason, K., …Chilton, N. (2019). Unravelling the Complexities of Pseudocontact Shift Analysis in Lanthanide Coordination Complexes of Differing Symmetry. Angewandte Chemie, 131(30), 10936-10400. https://doi.org/10.1002/anie.201906031

In two closely related series of eight‐coordinate lanthanide complexes, a switch in the sign of the dominant ligand field parameter and striking variations in the sign, amplitude and orientation of the main component of the magnetic susceptibility te... Read More about Unravelling the Complexities of Pseudocontact Shift Analysis in Lanthanide Coordination Complexes of Differing Symmetry.

Sensitivity of Magnetic Anisotropy in the Solid State for Lanthanide Complexes with Small Crystal Field Splitting (2019)
Journal Article

Knowledge of the crystal structure of a monometallic inorganic molecule is often sufficient to calculate its electronic structure and interpret its magnetic properties. Here we show that for a series of nine-coordinate lanthanide complexes based on t... Read More about Sensitivity of Magnetic Anisotropy in the Solid State for Lanthanide Complexes with Small Crystal Field Splitting.

­­Paramagnetic Lanthanide NMR Probes Signalling Changes in Zinc Concentration by Emission and Chemical Shift: A Proof of Concept Study (2019)
Journal Article

A zinc‐selective probe, based on a set of rare earth complexes of a modified DO3A macrocyclic ligand incorporating a tris‐pyridylamine (TPA) moiety has been structurally characterised in solution and in the solid‐state. One pyridine group possesses a... Read More about ­­Paramagnetic Lanthanide NMR Probes Signalling Changes in Zinc Concentration by Emission and Chemical Shift: A Proof of Concept Study.

Single-Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots (2018)
Journal Article
Chen, C., Ao, L., Wu, Y., Cifliku, V., Cardoso Dos Santos, M., Bourrier, E., …Hildebrandt, N. (2018). Single-Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots. Angewandte Chemie, 130(41), 13876-13881. https://doi.org/10.1002/ange.201807585

Fluorescence barcoding based on nanoparticles provides many advantages for multiparameter imaging. However, creating different concentration‐independent codes without mixing various nanoparticles and by using single wavelength excitation and emission... Read More about Single-Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots.

Exquisite sensitivity of the ligand field to solvation and donor polarisability in coordinatively saturated lanthanide complexes (2018)
Journal Article

Crystallographic, emission and NMR studies of a series of C3-symmetric, nine-coordinate substituted pyridyl triazacyclononane Yb(III) and Eu(III) complexes reveal the impact of local solvation and ligand dipolar polarisability on ligand field strengt... Read More about Exquisite sensitivity of the ligand field to solvation and donor polarisability in coordinatively saturated lanthanide complexes.

Lanthanide-induced relaxation anisotropy (2018)
Journal Article
Suturina, E. A., Mason, K., Geraldes, C. F., Chilton, N. F., Parker, D., & Kuprov, I. (2018). Lanthanide-induced relaxation anisotropy. Physical Chemistry Chemical Physics, 20(26), 17676-17686. https://doi.org/10.1039/c8cp01332b

Lanthanide ions accelerate nuclear spin relaxation by two primary mechanisms: dipolar and Curie. Both are commonly assumed to depend on the length of the lanthanide-nucleus vector, but not on its direction. Here we show experimentally that this is wr... Read More about Lanthanide-induced relaxation anisotropy.

Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence (2018)
Journal Article
Parker, D., Shuvaev, S., & Fox, M. A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition, 57(25), 7488-7492. https://doi.org/10.1002/anie.201801248

A series of three europium complexes is reported bearing picolyl amine moieties with different substituents, that possess differing binding affinities towards Zn2+ and three nucleotides ‐ AMP, ADP and ATP. A large increase of the total emission inten... Read More about Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence.

APTRA-based luminescent lanthanide complexes displaying enhanced selectivity for Mg2+ (2018)
Journal Article
Parker, D., Walter, E., & Williams, J. (2018). APTRA-based luminescent lanthanide complexes displaying enhanced selectivity for Mg2+. Chemistry - A European Journal, 24(30), 7724-7733. https://doi.org/10.1002/chem.201800745

A series of three europium(III) complexes has been created in which an APTRA moiety has been integrated into the sensitising chromophore (APTRA = o‐aminophenol‐N,N,N‐triacetate). The constitutionally isomeric complexes EuL1 and EuL2 feature the APTRA... Read More about APTRA-based luminescent lanthanide complexes displaying enhanced selectivity for Mg2+.

Chiral probes for α1-AGP reporting by species-specific induced circularly polarised luminescence (2018)
Journal Article
Shuvaev, S., Suturina, E. A., Mason, K., & Parker, D. (2018). Chiral probes for α1-AGP reporting by species-specific induced circularly polarised luminescence. Chemical Science, 9(11), 2996-3003. https://doi.org/10.1039/c8sc00482j

Luminescence spectroscopy has been used to monitor the selective and reversible binding of pH sensitive, macrocyclic lanthanide complexes, [LnL1], to the serum protein α1-AGP, whose concentration can vary significantly in response to inflammatory pro... Read More about Chiral probes for α1-AGP reporting by species-specific induced circularly polarised luminescence.

Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore (2018)
Journal Article
Parker, D., Williams, J., & Walter, E. (2018). Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore. Chemistry - A European Journal, 24(24), 6432-6441. https://doi.org/10.1002/chem.201800013

Four alkynyl‐1‐naphthyl fluorophores have been synthesised with tri‐ or pentadentate ligating groups suited to the binding of magnesium. Their photophysical and binding properties for magnesium, calcium and zinc ions have been assessed using absorpti... Read More about Tuning Mg2+ selectivity: comparative analysis of the photophysical properties of four fluorescent probes with an alkynyl-naphthalene fluorophore.

Enhanced selectivity for Mg2+ with a phosphinate-based chelate: APDAP versus APTRA (2018)
Journal Article
Walter, E. R., Fox, M. A., Parker, D., & Williams, J. G. (2018). Enhanced selectivity for Mg2+ with a phosphinate-based chelate: APDAP versus APTRA. Dalton Transactions, 47(6), 1755-1763. https://doi.org/10.1039/c7dt04698g

o-Aminophenol-N,N,O-triacetate, known as APTRA, is one of the most well-established ligands for targeting magnesium ions but, like other aminocarboxylate ligands, it binds Ca2+ much more strongly than Mg2+. The synthesis of an O-phosphinate analogue... Read More about Enhanced selectivity for Mg2+ with a phosphinate-based chelate: APDAP versus APTRA.

Enantioselective cellular localisation of europium(iii) coordination complexes (2017)
Journal Article
Frawley, A. T., Linford, H., Starck, M., Pal, R., & Parker, D. (2018). Enantioselective cellular localisation of europium(iii) coordination complexes. Chemical Science, 9(4), 1042-1049. https://doi.org/10.1039/c7sc04422d

The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(III) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed b... Read More about Enantioselective cellular localisation of europium(iii) coordination complexes.

Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence (2017)
Journal Article
Walter, E. R., Williams, J. G., & Parker, D. (2017). Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence. Chemical Communications, 53(100), 13344-13347. https://doi.org/10.1039/c7cc08361k

In a macrocyclic terbium complex incorporating a biaryl sensitiser, the observed variation of emission lifetime is shown to be determined by the solubility of oxygen in the solvent system and the relative energy of the chromophore excited state, rath... Read More about Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence.

Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes (2017)
Journal Article
Vonci, M., Mason, K., Suturina, E. A., Frawley, A. T., Worswick, S. G., Kuprov, I., …Chilton, N. F. (2017). Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes. Journal of the American Chemical Society, 139(40), 14166-14172. https://doi.org/10.1021/jacs.7b07094

Bleaney’s long-standing theory of magnetic anisotropy has been employed with some success for many decades to explain paramagnetic NMR pseudocontact shifts, and has been the subject of many subsequent approximations. Here, we present a detailed exper... Read More about Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes.

Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift (2017)
Journal Article
Parker, D., Kuprov, I., Suturina, E., Mason, K., & Geraldes, C. (2017). Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift. Angewandte Chemie International Edition, 56(40), 12215-12218. https://doi.org/10.1002/anie.201706931

A detailed analysis of paramagnetic NMR shifts in a series of isostructural lanthanide complexes relavant to PARASHIFT contrast agents reveals unexpected trends in the magnetic susceptibility anisotropy that cannot be explained by the commonly used B... Read More about Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift.

Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands (2017)
Journal Article
Farkas, E., Nagel, J., Waldron, B. P., Parker, D., Tóth, I., Brücher, E., …Baranyai, Z. (2017). Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands. Chemistry - A European Journal, 23(43), 10358-10371. https://doi.org/10.1002/chem.201701508

The development of 68Ge/68Ga generators has made the positron-emitting 68Ga isotope widely accessible and raised interest in new chelate complexes of Ga3+. The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATAm) l... Read More about Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands.

Responsive, Water-Soluble Europium(III) Luminescent Probes (2017)
Journal Article
Shuvaev, S., Starck, M., & Parker, D. (2017). Responsive, Water-Soluble Europium(III) Luminescent Probes. Chemistry - A European Journal, 23(42), 9974-9989. https://doi.org/10.1002/chem.201700567

The design principles, mechanism of action and performance of europium(III) complexes that serve as strongly emissive and responsive molecular probes in water are critically discussed. Examples of systems designed to assess pH, selected metal ions an... Read More about Responsive, Water-Soluble Europium(III) Luminescent Probes.

Selectively switching on europium emission in drug site one of human serum albumin (2017)
Journal Article
Shuvaev, S., Pal, R., & Parker, D. (2017). Selectively switching on europium emission in drug site one of human serum albumin. Chemical Communications, 53(50), 6724-6727. https://doi.org/10.1039/c7cc03071a

A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of europium emission, and accompanied by strong induced circularly polarised luminescence.

Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging (2017)
Journal Article
Finney, K. N., Harnden, A. C., Rogers, N. J., Senanayake, P. K., Blamire, A. M., O'Hogain, D., & Parker, D. (2017). Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging. Chemistry - A European Journal, 23(33), 7976-7989. https://doi.org/10.1002/chem.201700447

The chemical shift of paramagnetically shifted resonances in lanthanide(III) complexes encodes information about temperature and has also been made to report pH in parallel, through introduction of a single phosphonate group adjacent to the reporter... Read More about Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging.

PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes (2017)
Journal Article
Mason, K., Rogers, N., Suturina, E., Kuprov, I., Aguilar, J., Batsanov, A., …Parker, D. (2017). PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes. Inorganic Chemistry, 56(7), 4028-4038. https://doi.org/10.1021/acs.inorgchem.6b02291

Ytterbium and yttrium complexes of octadentate ligands based on 1,4,7,10-tetraazacyclododecane with a coordinated pyridyl group and either tricarboxylate (L1) or triphosphinate (L2) donors form twisted-square-antiprismatic structures. The former crys... Read More about PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes.

Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex (2017)
Journal Article
Neil, E., & Parker, D. (2017). Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex. RSC Advances, 7(8), 4531-4540. https://doi.org/10.1039/c6ra26662b

A europium complex bearing a phenylboronic acid group has been created that binds reversibly in methanol to sialic acid and lactic acid, as signalled by changes in the Eu total emission spectrum and the induction of strong circularly polarised lumine... Read More about Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex.

Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein (2017)
Journal Article
Jennings, L., Waters, R., Pal, R., & Parker, D. (2017). Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein. ChemMedChem, 12(3), 271-277. https://doi.org/10.1002/cmdc.201600571

Alpha-1-acid glycoprotein (α1-AGP) is an important blood plasma glycoprotein. Following an acute-phase reaction such as stress, inflammation, burn, or infection, the bloodstream concentration of α1-AGP can increase up to 400 % of its normal concentra... Read More about Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein.

Very bright, enantiopure europium(III) complexes allow time-gated chiral contrast imaging (2016)
Journal Article
Frawley, A., Pal, D., & Parker, D. (2016). Very bright, enantiopure europium(III) complexes allow time-gated chiral contrast imaging. Chemical Communications, 52(91), 13349-13352. https://doi.org/10.1039/c6cc07313a

Chiral image contrast is demonstrated using enantiopure Eu(III) complexes that emit right or left-handed circularly polarised light of opposite sign, at selected wavelengths.

Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides (2016)
Journal Article
Neil, E., Pal, R., Fox, M., & Parker, D. (2016). Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides. Dalton Transactions, 45(20), 8355-8366. https://doi.org/10.1039/c6dt01212d

Two bright, europium(III) complexes based on an achiral heptadentate triazacyclononane ligand bearing two strongly absorbing chromophores have been evaluated for the selective emission and CPL signalling of various chiral O-phosphono-anions. Binding... Read More about Induced europium CPL for the selective signalling of phosphorylated amino-acids and O-phosphorylated hexapeptides.

A New Paramagnetically Shifted Imaging Probe for MRI (2016)
Journal Article
Senanayake, P., Rogers, N., Harvey, P., Finney, K., Funk, A., Wilson, J., …Parker, D. (2017). A New Paramagnetically Shifted Imaging Probe for MRI. Magnetic Resonance in Medicine, 77(3), 1307-1317. https://doi.org/10.1002/mrm.26185

Purpose: To develop and characterize a new paramagnetic contrast agent for molecular imaging by MRI. Methods: A contrast agent was developed for direct MRI detection through the paramagnetically shifted proton magnetic resonances of two chemically eq... Read More about A New Paramagnetically Shifted Imaging Probe for MRI.

Chiral probe development for circularly polarised luminescence: comparative study of structural factors determining the degree of induced CPL with four heptacoordinate europium(III) complexes (2015)
Journal Article
Neil, E., Fox, M., Pal, R., Pålsson, L., O'Sullivan, B., & Parker, D. (2015). Chiral probe development for circularly polarised luminescence: comparative study of structural factors determining the degree of induced CPL with four heptacoordinate europium(III) complexes. Dalton Transactions, 44(33), 14937-14951. https://doi.org/10.1039/c5dt02358k

A series of bright, europium(III) complexes has been prepared based on an achiral heptadentate triazacyclononane ligand bearing two strongly absorbing, coordinated aralkynyl pyridyl moieties. The binding of chiral carboxylates, including α-hydroxy ac... Read More about Chiral probe development for circularly polarised luminescence: comparative study of structural factors determining the degree of induced CPL with four heptacoordinate europium(III) complexes.

Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation (2015)
Journal Article
Sim, N., Gottschalk, S., Pal, R., Delbianco, M., Degtyarik, D., Razansky, D., …Mishra, A. (2015). Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation. Chemical Communications, 51(82), 15149-15152. https://doi.org/10.1039/c5cc06277b

The cellular localisation and binding specificity of two NMDAR-targeted near-IR imaging probes has been examined by microscopy, followed by exemplification of MSOT to monitor simulated glutamate bursts in cellulo and a preliminary study in mice obser... Read More about Wavelength-dependent optoacoustic imaging probes for NMDA receptor visualisation.

Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues (2015)
Journal Article
Funk, A., Harvey, P., Finney, K., Fox, M., Kenwright, A., Rogers, N., …Parker, D. (2015). Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues. Physical Chemistry Chemical Physics, 17(25), 16507-16511. https://doi.org/10.1039/c5cp02210j

Measurements of the proton NMR paramagnetic relaxation rates for several series of isostructural lanthanide(III) complexes have been performed in aqueous solution over the field range 1.0 to 16.5 Tesla. The field dependence has been modeled using Blo... Read More about Challenging lanthanide relaxation theory: erbium and thulium complexes that show NMR relaxation rates faster than dysprosium and terbium analogues.

Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators (2015)
Journal Article
Seemann, J., Waldron, B., Roesch, F., & Parker, D. (2015). Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators. ChemMedChem, 10(6), 1019-1026. https://doi.org/10.1002/cmdc.201500092

The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO... Read More about Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators.

Critical design issues in the targeted molecular imaging of cell surface receptors (2015)
Journal Article
Sim, N., & Parker, D. (2015). Critical design issues in the targeted molecular imaging of cell surface receptors. Chemical Society Reviews, 44(8), 2122-2134. https://doi.org/10.1039/c4cs00364k

The imaging of cell-surface receptors can be achieved using several methods, including single photon emission tomography (SPECT) positron emission tomography (PET), optical imaging and magnetic resonance imaging (MRI). The application of targeted MRI... Read More about Critical design issues in the targeted molecular imaging of cell surface receptors.

Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes (2015)
Journal Article
Lawson, D., Barge, A., Terreno, E., Parker, D., Aime, S., & Botta, M. (2015). Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes. Dalton Transactions, 44(11), 4910-4917. https://doi.org/10.1039/c4dt02971b

Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type di-aqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contrib... Read More about Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes.

Synthesis of meta and para-substituted aromatic sulfonate derivatives of polydentate phenylazaphosphinate ligands: enhancement of the water solubility of emissive europium(III) EuroTracker® dyes (2014)
Journal Article
Delbianco, M., Lamarque, L., & Parker, D. (2014). Synthesis of meta and para-substituted aromatic sulfonate derivatives of polydentate phenylazaphosphinate ligands: enhancement of the water solubility of emissive europium(III) EuroTracker® dyes. Organic and Biomolecular Chemistry, 12(40), 8061-8071. https://doi.org/10.1039/c4ob01143k

The synthesis is described of a series of meta and para-substituted phenylsulfonate derivatives of very bright Eu(III) complexes with arylphosphinate groups and strongly absorbing arylalkynylpyridine moieties. The synthetic route involved the early i... Read More about Synthesis of meta and para-substituted aromatic sulfonate derivatives of polydentate phenylazaphosphinate ligands: enhancement of the water solubility of emissive europium(III) EuroTracker® dyes.

EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging (2014)
Journal Article
Butler, S., Delbianco, M., Lamarque, L., McMahon, B., Neil, E., Pal, R., …Zwier, J. (2015). EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging. Dalton Transactions, 44(11), 4791-4803. https://doi.org/10.1039/c4dt02785j

The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. St... Read More about EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.

Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo (2014)
Journal Article
Sim, N., Pal, R., Parker, D., Engelmann, J., Mishra, A., & Gottschalk, S. (2014). Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo. Organic and Biomolecular Chemistry, 12(46), 9389-9404. https://doi.org/10.1039/c4ob01848f

A second generation of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been synthesised and evaluated in cellulo, based on established bicyclic NMDA receptor antagonists. Their use as responsive MR imaging probes has been evalua... Read More about Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo.

Bright, highly water soluble triazacyclononane europium complexes to detect ligand binding with time-resolved FRET microscopy (2014)
Journal Article
Delbianco, M., Sadovnikova, V., Bourrier, E., Mathis, G., Lamarque, L., Zwier, J., & Parker, D. (2014). Bright, highly water soluble triazacyclononane europium complexes to detect ligand binding with time-resolved FRET microscopy. Angewandte Chemie International Edition, 53(40), 10718-10722. https://doi.org/10.1002/anie.201406632

Luminescent europium complexes are used in a broad range of applications as a result of their particular emissive properties. The synthesis and application of bright, highly water-soluble, and negatively charged sulfonic- or carboxylic acid derivativ... Read More about Bright, highly water soluble triazacyclononane europium complexes to detect ligand binding with time-resolved FRET microscopy.

Selective ion pair recognition of citrate and zinc ions in water by ratiometric luminescence signaling (2014)
Journal Article
McMahon, B., & Parker, D. (2014). Selective ion pair recognition of citrate and zinc ions in water by ratiometric luminescence signaling. RSC Advances, 4(71), 37649-37654. https://doi.org/10.1039/c4ra07894b

Emission from a bright europium(III) complex, based on a 1,4,7-triazacyclononane ring bearing an alkyliminodiacetate group, is modulated only when in the presence of zinc(II) ions and a carboxylate anion and was characterised by ratiometric luminesce... Read More about Selective ion pair recognition of citrate and zinc ions in water by ratiometric luminescence signaling.

Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium (2014)
Journal Article
Soulié, M., Latzko, F., Bourrier, E., Placide, V., Butler, S. J., Pal, R., …Maury, O. (2014). Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium. Chemistry - A European Journal, 20(28), 8636 -8646. https://doi.org/10.1002/chem.201402415

A series of europium and terbium complexes based on a functionalized triazacyclononane carboxylate or phosphinate macrocyclic ligand is described. The influence of the anionic group, that is, carboxylate, methylphosphinate, or phenylphosphinate, on t... Read More about Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium.

Synthesis, stereocontrol and structural studies of highly luminescent chiral tris-amidepyridyl-triazacyclononane lanthanide complexes (2014)
Journal Article
Neil, E. R., Funk, A. M., Yufit, D. S., & Parker, D. (2014). Synthesis, stereocontrol and structural studies of highly luminescent chiral tris-amidepyridyl-triazacyclononane lanthanide complexes. Dalton Transactions, 43(14), 5490-5504. https://doi.org/10.1039/c3dt53000k

The configuration of the remote amide chiral moiety determines the helicity of the metal complex in Ln(III) complexes of nonadentate N6O3 ligands based on triazacyclononane. Solution NMR studies revealed the presence of a dominant isomer whose propor... Read More about Synthesis, stereocontrol and structural studies of highly luminescent chiral tris-amidepyridyl-triazacyclononane lanthanide complexes.

Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes (2014)
Journal Article
Carr, R., Puckrin, R., McMahon, B. K., Pal, R., Parker, D., & Pålsson, L. (2014). Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes. Methods and Applications in Fluorescence, 2(2), Article 024007. https://doi.org/10.1088/2050-6120/2/2/024007

A circularly polarized luminescence (CPL) spectrometer has been built and used to study the binding interaction of lactate and four different proteins with racemic EuIII and TbIII complexes in aqueous solution. Lactate binding gives rise to strong in... Read More about Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes.

Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes (2014)
Journal Article
Funk, A., Finney, K., Harvey, P., Kenwright, A., Neil, E., Rogers, N., …Parker, D. (2014). Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes. Chemical Science, 6(3), 1655-1662. https://doi.org/10.1039/c4sc03429e

The origins of the breakdown of Bleaney's theory of magnetic anisotropy are described, based on an analysis of eleven different complexes of the second half of the 4f elements that form isostructural series. An examination of the chemical shift and r... Read More about Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes.

Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes (2014)
Journal Article
Butler, S. J., Delbianco, M., Evans, N. H., Frawley, A. T., Pal, R., Parker, D., …Yufit, D. S. (2014). Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes. Dalton Transactions, 43(15), 5721-5730. https://doi.org/10.1039/c4dt00253a

The synthetic utility of europium complexes with three coordinated 4-bromopyridyl groups for chromophore elaboration has been assessed in palladium-catalysed Sonogashira coupling reactions, and in copper(I) mediated click reactions of the triazide de... Read More about Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes.

Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging (2014)
Journal Article
De Luca, E., Harvey, P., Chalmers, K. H., Mishra, A. P., Senanayake, K., Wilson, J. I., …Parker, D. (2014). Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging. JBIC Journal of Biological Inorganic Chemistry, 19(2), 215-227. https://doi.org/10.1007/s00775-013-1028-y

Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre.... Read More about Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging.

Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots (2014)
Journal Article
Palmer, A. J., Ford, S. H., Butler, S. J., Hawkins, T. J., Hussey, P. J., Pal, R., …Parker, D. (2014). Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots. RSC Advances, 4(18), 9356-9366. https://doi.org/10.1039/c3ra45426f

The cell-staining behaviour of a set of five emissive europium complexes has been studied in Nicotiana tabacum BY-2 cells and pollen tubes, Nicotiana benthamiana plant leaves and in the root hairs of the wild-type plant Arabidopsis thaliana (Columbia... Read More about Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots.

EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging (2014)
Journal Article
Butler, S. J., Lamarque, L., Pal, R., & Parker, D. (2014). EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging. Chemical Science, 2014(5), 1750-1756. https://doi.org/10.1039/c3sc53056f

Nine very bright europium(III) complexes with different macrocyclic ligands have been prepared that exhibit excellent cell uptake behaviour and distinctive sub-cellular localisation profiles, allowing the use of fluorescence microscopy and time-gated... Read More about EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging.

Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes (2013)
Other
Mishra, A., Mishra, R., Gottschalk, S., Pal, R., Sim, N., Engelmann, J., …Parker, D. (2014). Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes

A series of bimodal metabotropic glutamate-receptor targeted MRI contrast agents has been developed and evaluated, based on established competitive metabotropic Glu receptor subtype 5 (mGluR5) antagonists. In order to directly visualize mGluR5 bindin... Read More about Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes.

Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells (2011)
Journal Article
Smith, D., Law, G., Benjamin, S., Pal, R., Parker, D., & Wong, K. (2011). Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells. Chemical Communications, 47(26), 7347-7349. https://doi.org/10.1039/c1cc11853f

Image and spectral intensity from bicarbonate-selective europium(III) probes localised in the mitochondria of cells is modulated reversibly by variation of external pCO2, and is suppressed by addition of the carbonic anhydrase inhibitor, acetazolomid... Read More about Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells.

Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes (2010)
Journal Article
New, E., Congreve, A., & Parker, D. (2010). Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes. Chemical Science, 1(1), 111-118. https://doi.org/10.1039/c0sc00105h

A series of experiments has been undertaken in order to gain a greater understanding of the cellular uptake and localisation behaviour of emissive lanthanide complexes as cellular stains or probes. Out of a large number of structurally related comple... Read More about Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes.

Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand. (2006)
Journal Article
Senanayake, K., Thompson, A., Howard, J., Botta, M., & Parker, D. (2006). Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand. Dalton Transactions, 5423-5428. https://doi.org/10.1039/b612189f

The macrocyclic ligand 1,4,7,10-tetraazacyclododecane-1,4,7-triyl(methylenebenzyl-phosphinic acid) H3L3, has been prepared and its complexes with Eu, Gd and Tb(III) studied by NMR, relaxometry, luminescence and single crystal X-ray crystallography. I... Read More about Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand..

A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants. (2006)
Journal Article
Poole, R., Kielar, F., Richardson, S., Stenson, P., & Parker, D. (2006). A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants. Chemical Communications, 4084-4086. https://doi.org/10.1039/b611259e

The excited states of Tb and Eu complexes of a common macrocyclic ligand are quenched preferentially by electron transfer from the urate anion, allowing the creation of a new assay to measure uric acid in biological fluids.

On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes (2006)
Journal Article
Thompson, A., Parker, D., Fulton, D., Howard, J., Pandya, S., Puschmann, H., …Aime, S. (2006). On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes. Dalton Transactions, 5605-5616. https://doi.org/10.1039/b606206g

The crystal structures of the hydrated salts of [Gd.DOTAM]3+ and its more hydrophobic derivative [Gd.2]3+, bearing 4 -phenylethyl groups, (both Gd and Yb salts) are reported and compared. The nature of the anion determines the degree of ordering in t... Read More about On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes.

A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment (2006)
Journal Article
Atkinson, P., Murray, B., & Parker, D. (2006). A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment. Organic and Biomolecular Chemistry, 4(16), 3166-3171. https://doi.org/10.1039/b608528h

The binding of two cationic europium complexes to a differentially phosphorylated insulin receptor peptide has been studied by emission spectroscopy and 31P NMR and 1H NMR TOCSY methods. Analysis of the europium emission and NMR spectral data was con... Read More about A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment.

Structural characterisation of a diprotonated ligand lanthanide complex - a key intermediate in lanthanide ion association and complex dissociation pathways (2006)
Journal Article
Stenson, P., Thompson, A., & Parker, D. (2006). Structural characterisation of a diprotonated ligand lanthanide complex - a key intermediate in lanthanide ion association and complex dissociation pathways. Dalton Transactions, 2006(27), 3291-3293. https://doi.org/10.1039/b605876k

The X-ray structure is reported of a diprotonated Gd(III) tetra-aqua complex of the ligand 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane (DOTAM), a thermodynamic intermediate in metal ion association and dissociation pathways.

Engineering emissive europium and terbium complexes for molecular imaging and sensing. (2006)
Journal Article
Pandya, S., Yu, J., & Parker, D. (2006). Engineering emissive europium and terbium complexes for molecular imaging and sensing. Dalton Transactions, 2006(23), 2757-2766. https://doi.org/10.1039/b514637b

Emissive f-block coordination complexes constitute an important class of optical probes, with applications ranging from sensing of bioactive species, high throughput assays and screening protocols in vitro, to time-resolved imaging studies in cellulo... Read More about Engineering emissive europium and terbium complexes for molecular imaging and sensing..

Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence (2006)
Journal Article
Atkinson, P., Findlay, K., Kielar, F., Pal, D., Parker, D., Poole, R., …Yu, J. (2006). Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence. Organic and Biomolecular Chemistry, 4(9), 1707-1722. https://doi.org/10.1039/b601357k

Several azaxanthone and azathioxanthone sensitising chromophores have been incorporated into macrocyclic ligands and form well-defined Eu and Tb complexes in polar media. Excitation of the heterocyclic chromophore in the range 330 to 382 nm leads to... Read More about Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence.

Glycoconjugates of gadolinium complexes for MRI applications. (2006)
Journal Article
Fulton, D., Elemento, E., Aime, S., Chaabane, L., Botta, M., & Parker, D. (2006). Glycoconjugates of gadolinium complexes for MRI applications. Chemical Communications, 2006(10), 1064-1066. https://doi.org/10.1039/b517997a

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional cou... Read More about Glycoconjugates of gadolinium complexes for MRI applications..

A europium complex that selectively stains nucleoli of cells (2006)
Journal Article
Yu, J., Parker, D., Pal, R., Poole, R., & Cann, M. (2006). A europium complex that selectively stains nucleoli of cells. Journal of the American Chemical Society, 128(7), 2294-2299. https://doi.org/10.1021/ja056303g

A europium complex selectively staining the nucleolus of NIH 3T3, HeLa, and HDF cells is reported. This complex possesses not only the advantage of the long lifetime of europium emission (0.3 ms), but also a chromophore that allows excitation at a re... Read More about A europium complex that selectively stains nucleoli of cells.

NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions (2005)
Journal Article
Atkinson, P., Bretonniere, Y., Parker, D., & Muller, G. (2005). NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions. Helvetica Chimica Acta, 88(3), 391-405

The binding of a series of phosphate anions to coordinatively unsaturated macrocyclic complexes of Yb, Tm, and Eu was studied by H-1-NMR, emission and circularly polarized luminescence (CPL) spectroscopy. Each ternary adduct was distinguished by its... Read More about NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions.

A pH-insensitive, ratiometric chemosensor for citrate using europium luminescence (2005)
Journal Article
Parker, D., & Yu, J. (2005). A pH-insensitive, ratiometric chemosensor for citrate using europium luminescence. Chemical Communications, 3141-3143

A chemoselective sensor for the citrate anion has been devised, based on a new europium complex that offers ratiometric analysis of the long-lived emission.

Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen (2005)
Journal Article
Yu, J., & Parker, D. (2005). Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen. European Journal of Organic Chemistry, 4249-4252

A regioselective synthetic route that allows the construction of tri-functionally substituted cyclen is described. This facilitates the synthesis of a europium complex that exhibits a good photoresponse to malate, forming the basis of a chemoselectiv... Read More about Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen.

The DNA sequence of the human X chromosome (2005)
Journal Article
Ross, M., Grafham, D., Coffey, A., Scherer, S., McLay, K., Muzny, D., …Sear, S. (2005). The DNA sequence of the human X chromosome. Nature, 434(7031), 325-337

The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of... Read More about The DNA sequence of the human X chromosome.

Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo' (2005)
Journal Article
Poole, R., Bobba, G., Cann, M., Frias, J., Parker, D., & Peacock, R. (2005). Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'. Organic and Biomolecular Chemistry, 3(6), 1013-1024. https://doi.org/10.1039/b418964g

The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a t... Read More about Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'.

Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates (2005)
Journal Article
Fulton, D., O'Halloran, M., Parker, D., Senanayake, K., Botta, M., & Aime, S. (2005). Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates. Chemical Communications, 474-476

Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.

NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA (2004)
Journal Article
Thompson, N., Parker, D., Schmitt-Willich, H., Sulzle, D., Muller, G., & Riehl, J. (2004). NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA. Dalton Transactions, 1892-1895

The solution structure of the diastereoisomers of (S)-Eu-EOB-DTPA has been analysed by H-1 NMR, CD and CPL spectroscopy. Two major species exist which possess very similar 1H NMR paramagnetic shifts and emission spectra, consistent with a 9-coordinat... Read More about NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA.

Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex (2004)
Journal Article
Dickins, R., Batsanov, A., Howard, J., Parker, D., Puschmann, H., & Salamano, S. (2004). Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex. Dalton Transactions, 70-80. https://doi.org/10.1039/b311791j

A detailed investigation of the nature of the binding of each of the 20 common alpha-amino acids and various selected dipeptides to a chiral, diaqua-ytterbium complex in aqueous solution has been carried out. Analysis of the dipolar H-1 NMR paramagne... Read More about Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex.

Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex (2004)
Journal Article
Congreve, A., Parker, D., Gianolio, E., & Botta, M. (2004). Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex. Dalton Transactions, 1441-1445

Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL(1)], bearing an N-linked CH2CH2NHCO-pyridyl moiety,... Read More about Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex.

Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission (2004)
Journal Article
Bretonniere, Y., Cann, M., Parker, D., & Slater, R. (2004). Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission. Organic and Biomolecular Chemistry, 2(11), 1624-1632. https://doi.org/10.1039/b400734b

A series of cationic, zwitterionic and anionic macrocyclic europium complexes has been prepared incorporating a N or C- linked acridone chromophore that allows sensitisation of Eu emission following excitation at 390-410nm. Each of these complexes se... Read More about Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission.

Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media (2004)
Journal Article
Parker, D. (2004). Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media. Chemical Society Reviews, 33(3), 156-165. https://doi.org/10.1039/b311001j

Lanthanide complexation chemistry has been studied intensively over the past 15 years and progress has been stimulated by the advent of well-defined, kinetically robust systems tailored to applications as bioactive probes for magnetic resonance and l... Read More about Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media.

Chemoselective signalling of selected phospho-anions using lanthanide luminescence (2004)
Journal Article
Atkinson, P., Bretonniere, Y., & Parker, D. (2004). Chemoselective signalling of selected phospho-anions using lanthanide luminescence. Chemical Communications, 438-439

Selectivity in the binding of phosphorylated tyrosine residues to aqua-lanthanide complexes is signalled by changes in spectral form by luminescence emission and H-1 NMR spectroscopy.

Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series (2003)
Journal Article
Parker, D., Puschmann, H., Batsanov, A., & Senanayake, K. (2003). Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series. Inorganic Chemistry, 42(26), 8646-8651

The structures of 10 isomorphous lanthanide (Ln) complexes of a chiral DOTA tetra-amide ligand (L-1), [LnL(1)(H2O)](CF3-SO3)(3).3H(2)O, crystallizing in space group P2(1), have been studied by single-crystal X-ray diffraction. The Ln coordination is... Read More about Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series.

Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes (2003)
Journal Article
Frias, J., Bobba, G., Cann, M., Hutchison, C., & Parker, D. (2003). Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes. Organic and Biomolecular Chemistry, 1(6), 905-907

Nonacoordinate Delta- and Lambda-Eu and Tb complexes have been tested as imaging and reactive probes in mouse fibroblast (NIH 3T3) cells. The uptake of these complexes by the cells was assessed by fluorescence microscopy. Complex-induced DNA damage w... Read More about Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes.

The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions (2003)
Journal Article
Henze, O., Parker, D., & Feast, W. (2003). The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions. Journal of materials chemistry, 13(6), 1269-1273

A series of polydisperse amphiphilic alpha,alpha-linked sexithiophenes with an oligoethylene oxide substituent at one terminal alpha-position and a hydrogen atom or a hexyl group at the other have been synthesised via Stille and Suzuki cross coupling... Read More about The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions.

Correlation of optical and NMR spectral information with coordination variation for axially symmetric macrocyclic Eu(III) and Yb(III) complexes: axial donor polarisability determines ligand field and cation donor preference (2003)
Journal Article
Dickins, R., Parker, D., Bruce, J., & Tozer, D. (2003). Correlation of optical and NMR spectral information with coordination variation for axially symmetric macrocyclic Eu(III) and Yb(III) complexes: axial donor polarisability determines ligand field and cation donor preference. Dalton Transactions, 1264-1271

In Bleaney's theory of magnetic anisotropy, the second-order crystal field coefficient, B-o(2), is predicted to determine the dipolar NMR shift of paramagnetic lanthanide complexes in solution. This parameter has been measured directly, by analysing... Read More about Correlation of optical and NMR spectral information with coordination variation for axially symmetric macrocyclic Eu(III) and Yb(III) complexes: axial donor polarisability determines ligand field and cation donor preference.

Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands (2003)
Journal Article
Congreve, A., Kataky, R., Knell, M., Parker, D., Puschmann, H., Senanayake, K., & Wylie, L. (2003). Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands. New Journal of Chemistry, 27(1), 98-106

The sixteen neutral ML2 complexes of Co, Ni, Cu and Zn(II) with the p-toluenesulfonamide and trifluoromethylsulfonamide derivatives of 2-aminomethylpyridine (L-1, L-2) and its 6-Me homologue (L-3, L-4) have been characterised by low temperature X-ray... Read More about Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands.

The nature of the counter-anion can determine the rate of water exchange in a metal aqua complex (2003)
Journal Article
Barge, A., Botta, M., Parker, D., & Puschmann, H. (2003). The nature of the counter-anion can determine the rate of water exchange in a metal aqua complex. Chemical Communications, 1386-1387

The nature of the counter-anion determines the water exchange rate for a series of cationic gadolinium complexes in aqueous solution, as a consequence of the ordering effect that the anion imposes on the structure of the second hydration sphere.

Aqueous solutions of uranium(VI) as studied by time-resolved emission spectroscopy: A round-robin test (2003)
Journal Article
Billard, I., Ansoborlo, E., Apperson, K., Arpigny, S., Azenha, M., Birch, D., …Mein, G. (2003). Aqueous solutions of uranium(VI) as studied by time-resolved emission spectroscopy: A round-robin test. Applied Spectroscopy, 57(8), 1027-1038

Results of an inter-laboratory round-robin study of the application of time-resolved emission spectroscopy (TRES) to the speciation of uranium(VI) in aqueous media are presented. The round-robin study involved 13 independent laboratories, using vario... Read More about Aqueous solutions of uranium(VI) as studied by time-resolved emission spectroscopy: A round-robin test.

Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study (2003)
Journal Article
Botta, M., Aime, S., Barge, A., Bobba, G., Dickins, R., Parker, D., & Terreno, E. (2003). Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study. Chemistry - A European Journal, 9(9), 2102-2109

The H-1 and O-17 NMR relaxometric properties of two cationic complexes formed by Gd-III with a macrocyclic heptadentate triamide ligand, L-1, and its N-methylated analogue, L-2, have been investigated in aqueous media as a function of pH, temperature... Read More about Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study.

Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding (2003)
Journal Article
Bobba, G., Bretonniere, Y., Frias, J., & Parker, D. (2003). Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding. Organic and Biomolecular Chemistry, 1(11), 1870-1872

In cationic nine-coordinate chiral terbium and europium complexes incorporating exciton-coupled naphthyl groups and a tetraazatriphenylene sensitising chromophore, efficient intramolecular energy transfer occurs leading to population of the naphthyl... Read More about Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding.

Highly emissive, nine-coordinate enantiopure lanthanide complexes incorporating tetraazatriphenylenes as probes for DNA (2002)
Journal Article
Bobba, G., Frias, J., & Parker, D. (2002). Highly emissive, nine-coordinate enantiopure lanthanide complexes incorporating tetraazatriphenylenes as probes for DNA. Chemical Communications, 890-891

The interaction of q = 0 Delta- and Lambda-Tb and Eu complexes with poly(dAdT), poly(dGdC) and calf-thymus DNA has been examined by absorption, emission and chiroptical spectroscopy and is sensitive to complex helicity, base-pair type and the nature... Read More about Highly emissive, nine-coordinate enantiopure lanthanide complexes incorporating tetraazatriphenylenes as probes for DNA.

Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes (2002)
Journal Article
Aime, S., Barge, A., Batsanov, A., Botta, M., Castelli, D., Fedeli, F., …Puschmann, H. (2002). Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes. Chemical Communications, 1120-1121

The rate of axial water exchange in well-defined series of lanthanide complexes depends on the extent of second sphere hydration which is determined by complex hydrophobicity and the nature of the lanthanide ion and its counter-ion.

Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand (2002)
Journal Article
Muller, G., Kean, S., Parker, D., & Riehl, J. (2002). Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand. The Journal of Physical Chemistry A, 106(51), 12349-12355

The temperature and pressure dependence of the F-7(0) --> D-5(0) and F-7(1) --> D-5(0) excitation spectra for aqueous solutions of Eu(III) with race mic-tetra(alpha-carboxyethyl)DOTA have been measured. Individual excitation and emission peaks have b... Read More about Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand.

Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay (2002)
Journal Article
Blair, S., Kataky, R., & Parker, D. (2002). Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay. New Journal of Chemistry, 26(5), 530-535

Cationic terbium complexes bearing an N-methylphenanthridinium chromophore have been incorporated in sol gel thin films and their response characteristics analysed with respect to variations in dissolved oxygen concentration. Analysis of the emission... Read More about Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay.

Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes (2002)
Journal Article
Dickins, R., Aime, S., Batsanov, A., Beeby, A., Botta, M., Bruce, J., …Puschmann, H. (2002). Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. Journal of the American Chemical Society, 124(43), 12697-12705. https://doi.org/10.1021/ja020836x

The nature of the ternary complexes formed in aqueous media at ambient pH on reversible binding of acetate, lactate, citrate, and selected amino acids and peptides to chiral diaqua europium, gadolinium, or ytterbium cationic complexes has been examin... Read More about Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes.

Ratiometric probes for hydrogencarbonate analysis in intracellular or extracellular environments using europium luminescence (2002)
Journal Article
Bretonnière, Y., Cann, M., Parker, D., & Slater, R. (2002). Ratiometric probes for hydrogencarbonate analysis in intracellular or extracellular environments using europium luminescence. Chemical Communications, 2002(17), 1930-1931. https://doi.org/10.1039/b206286k

A series of six, cationic, zwitterionic and anionic Eu complexes has been examined for the analysis of hydrogencarbonate concentration in the intracellular and extracellular ranges; an anionic complex incorporating three glutarate residues and a sens... Read More about Ratiometric probes for hydrogencarbonate analysis in intracellular or extracellular environments using europium luminescence.

Survey of factors determining the circularly polarised luminescence of macrocyclic lanthanide complexes in solution (2002)
Journal Article
Bruce, J., Parker, D., Lopinski, S., & Peacock, R. (2002). Survey of factors determining the circularly polarised luminescence of macrocyclic lanthanide complexes in solution. Chirality, 14(7), 562-567

The development of emissive lanthanide complexes as structural or reactive probes to signal changes in their local chiral or ionic environment has been inhibited by the lack of understanding of correlating structural and electronic spectral informati... Read More about Survey of factors determining the circularly polarised luminescence of macrocyclic lanthanide complexes in solution.

Sensitised luminescence from phenanthridine appended lanthanide complexes: analysis of triplet mediated energy transfer processes in terbium, europium and neodymium complexes (2001)
Journal Article
Beeby, A., Faulkner, S., Parker, D., & Williams, J. (2001). Sensitised luminescence from phenanthridine appended lanthanide complexes: analysis of triplet mediated energy transfer processes in terbium, europium and neodymium complexes. Journal of the Chemical Society-Perkin Transactions 2, 1268-1273

Time resolved luminescence spectroscopy and laser flash photolysis have been used to probe the energy transfer processes in the europium, neodymium and terbium complexes of ligand, 1. The ligand, chosen because of the high kinetic stability of lantha... Read More about Sensitised luminescence from phenanthridine appended lanthanide complexes: analysis of triplet mediated energy transfer processes in terbium, europium and neodymium complexes.

Towards rational design of fast water-exchanging Gd(dota-like) contrast agents? Importance of the M/m ratio (2001)
Journal Article
Dunand, F., Dickins, R., Parker, D., & Merbach, A. (2001). Towards rational design of fast water-exchanging Gd(dota-like) contrast agents? Importance of the M/m ratio. Chemistry - A European Journal, 7(23), 5160-5167

H-1 NMR line-shape analysis and magnetisation-transfer experiments at variable temperature and pressure have been used to elucidate the solution dynamics of both M and m isomers of three [Eu(dota-tetraamide)(H2O)](3+) complexes. The direct H-1 NMR ob... Read More about Towards rational design of fast water-exchanging Gd(dota-like) contrast agents? Importance of the M/m ratio.

A Preparative and Solution Study of a Modified b-Cyclodextrin and its Europium(III) Complex, and their Interactions with Racemic Amino Acid Anions. (2001)
Journal Article
Kean, S., Easton, C., Lincoln, S., & Parker, D. (2001). A Preparative and Solution Study of a Modified b-Cyclodextrin and its Europium(III) Complex, and their Interactions with Racemic Amino Acid Anions. Australian Journal of Chemistry, 54(8), 535-539. https://doi.org/10.1071/ch01102

The synthesis and characterization of 6A-deoxy-6A-(1,4,7-tri(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-10-yl)-β-cyclodextrin (1b) are reported. A fluorescence lifetime study of its Eu3+ complex (1c) is consistent with one water coordinating Eu... Read More about A Preparative and Solution Study of a Modified b-Cyclodextrin and its Europium(III) Complex, and their Interactions with Racemic Amino Acid Anions..

Lanthanide macrocyclic quinolyl conjugates as luminescent molecular-level devices (2001)
Journal Article
Gunnlaugsson, T., Mac Donaill, D., & Parker, D. (2001). Lanthanide macrocyclic quinolyl conjugates as luminescent molecular-level devices. Journal of the American Chemical Society, 123(51), 12866-12876

The Eu(III) tetraazamacrocyclic complexes [Eu.1] and [Eu.2], and the Tb(III) and Yb(III) complexes [Tb.1] and [Yb.2], have been synthesized as luminescent molecular-level devices. The Eu complexes exhibit unique dual pH switching behavior in water un... Read More about Lanthanide macrocyclic quinolyl conjugates as luminescent molecular-level devices.

Modulation of the water exchange rates in Gd-DO3A complex by formation of ternary complexes with carboxylate ligands (2001)
Journal Article
Aime, S., Botta, M., Bruce, J., Mainero, V., Parker, D., & Terreno, E. (2001). Modulation of the water exchange rates in Gd-DO3A complex by formation of ternary complexes with carboxylate ligands. Chemical Communications, 115-116

Ternary complexes of formula [Gd-DO3A-L-(H2O)] (where L is a carboxylate-containing ligand) display exchange lifetimes of the metal-coordinated water that can be modulated as a function of L.

A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding (2001)
Journal Article
Messeri, D., Lowe, M. P., Parker, D., & Botta, M. (2001). A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding. Chemical Communications, 2742-2743. https://doi.org/10.1039/b108294a

The high relaxivity of [GdaDO3A](3-) (r(1p) = 12.3 mM(-1) s(- 1), 20 MHz, 298 K, iota (m) = 30 ns) in water is maintained in serum solution because the binding of protein and endogeneous anions, e.g. HCO3-/CO32- is suppressed by electrostatic repulsi... Read More about A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and protein binding.

Experimental assessment of lanthanide ion donor preference: spectroscopic and theoretical dissection of static charge and dynamic polarisation contributions to axial ligation in a C-4- symmetric chiral europium complex (2001)
Journal Article
Bruce, J., Parker, D., & Tozer, D. (2001). Experimental assessment of lanthanide ion donor preference: spectroscopic and theoretical dissection of static charge and dynamic polarisation contributions to axial ligation in a C-4- symmetric chiral europium complex. Chemical Communications, 2250-2251

Measurements of the equilibrium constants for ligand exchange (MeCN, 295 K) involving the axial donor in a C-4-symmetric, mono-capped, square antiprismatic cationic Eu complex, supported by calculations based on an electrostatic perturbation model, h... Read More about Experimental assessment of lanthanide ion donor preference: spectroscopic and theoretical dissection of static charge and dynamic polarisation contributions to axial ligation in a C-4- symmetric chiral europium complex.

Narrow-range optical pH sensors based on luminescent europium and terbium complexes immobilized in a sol gel glass (2001)
Journal Article
Blair, S., Lowe, M., Mathieu, C., Parker, D., Senanayake, P., & Kataky, R. (2001). Narrow-range optical pH sensors based on luminescent europium and terbium complexes immobilized in a sol gel glass. Inorganic Chemistry, 40(23), 5860-5867

The metal-based emission of a series of luminescent europium and terbium complexes incorporating an aromatic chromophore is rendered pH-dependent either through perturbation of the aryl singlet or triplet energy or by modulating the degree of quenchi... Read More about Narrow-range optical pH sensors based on luminescent europium and terbium complexes immobilized in a sol gel glass.

DNA binding studies of cationic lanthanide complexes bearing a phenanthridinium group (2001)
Journal Article
Bobba, G., Kean, S., Parker, D., Beeby, A., & Baker, G. (2001). DNA binding studies of cationic lanthanide complexes bearing a phenanthridinium group. Journal of the Chemical Society-Perkin Transactions 2, 1738-1741

The binding of tetracationic Lambda- and Delta -europium complexes of tetraamide and triamide ligands incorporating an N-methylphenanthridinium group to calf-thymus DNA, poly(dGdC) and super-coiled plasmid DNA has been monitored by absorption, lumine... Read More about DNA binding studies of cationic lanthanide complexes bearing a phenanthridinium group.

Chiroptical, ESMS and NMR spectroscopic study of the interaction of enantiopure lanthanide complexes with selected self-complementary dodecamer oligonucleotides (2001)
Journal Article
Bobba, G., Dickins, R., Kean, S., Mathieu, C., Parker, D., Peacock, R., …Geraldes, C. (2001). Chiroptical, ESMS and NMR spectroscopic study of the interaction of enantiopure lanthanide complexes with selected self-complementary dodecamer oligonucleotides. Journal of the Chemical Society-Perkin Transactions 2, 1729-1737

The interaction of Delta- and Lambda -Eu and Yb cationic complexes bearing an N-methylphenanthridinium chromophore with [(CG)(6)](2), [(AT)(6)], and [CGCGAATTCGCG](2) has been interrogated by ESMS, H-1 NMR, absorption, difference circular dichroism,... Read More about Chiroptical, ESMS and NMR spectroscopic study of the interaction of enantiopure lanthanide complexes with selected self-complementary dodecamer oligonucleotides.

Chiral lanthanide complexes (2001)
Journal Article
Kean, S., Bobba, G., Mathieu, C., Parker, D., & Smith, M. (2001). Chiral lanthanide complexes. Journal of Inorganic Biochemistry, 86(1), 290-290

pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation (2001)
Journal Article
Lowe, M., Parker, D., Reany, O., Aime, S., Botta, M., Castellano, G., …Pagliarin, R. (2001). pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation. Journal of the American Chemical Society, 123(31), 7601-7609. https://doi.org/10.1021/ja0103647

A series of macrocyclic Eu, Gd, and Tb complexes has been prepared in which the intramolecular ligation of a beta - arylsulfonamide nitrogen is rendered pH-dependent, giving rise to changes in the hydration state, q, at the lanthanide center. In comp... Read More about pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation.

pH Switched sensitisation of europium(III) by a dansyl group (2001)
Journal Article
Lowe, M., & Parker, D. (2001). pH Switched sensitisation of europium(III) by a dansyl group. Inorganica Chimica Acta, 317(1-2), 163-173

The Eu(III), Tb(III) and Y(III) complexes of an eight- coordinate ligand containing a pendant dansylamidoethyl group were synthesised. Reversible intramolecular binding of the dansylamide nitrogen was demonstrated by UV absorption and luminescence pH... Read More about pH Switched sensitisation of europium(III) by a dansyl group.

The Selectivity of Reversible Oxy-Anion Binding in Aqueous Solution at a Chiral Europium and Terbium Center: Signaling of Carbonate Chelation by Changes in the Form and Circular Polarisation of Luminescence Emission (2000)
Journal Article
Parker, D., Bruce, J., Dickins, R., & Govenlock, L. (2000). The Selectivity of Reversible Oxy-Anion Binding in Aqueous Solution at a Chiral Europium and Terbium Center: Signaling of Carbonate Chelation by Changes in the Form and Circular Polarisation of Luminescence Emission. Journal of the American Chemical Society, 122, 9674-9684

Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states (1999)
Journal Article
Beeby, A., Clarkson., I., Dickins, R., Faulkner, S., Parker, D., Royle, L., …Woods, M. (1999). Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states. Journal of the Chemical Society. Perkin Transactions 2 (2001), 1999(3), 493-503