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David Parker's Outputs (129)

Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots (2014)
Journal Article
Palmer, A. J., Ford, S. H., Butler, S. J., Hawkins, T. J., Hussey, P. J., Pal, R., …Parker, D. (2014). Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots. RSC Advances, 4(18), 9356-9366. https://doi.org/10.1039/c3ra45426f

The cell-staining behaviour of a set of five emissive europium complexes has been studied in Nicotiana tabacum BY-2 cells and pollen tubes, Nicotiana benthamiana plant leaves and in the root hairs of the wild-type plant Arabidopsis thaliana (Columbia... Read More about Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots.

EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging (2014)
Journal Article
Butler, S. J., Lamarque, L., Pal, R., & Parker, D. (2014). EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging. Chemical Science, 2014(5), 1750-1756. https://doi.org/10.1039/c3sc53056f

Nine very bright europium(III) complexes with different macrocyclic ligands have been prepared that exhibit excellent cell uptake behaviour and distinctive sub-cellular localisation profiles, allowing the use of fluorescence microscopy and time-gated... Read More about EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging.

Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes (2013)
Other
Mishra, A., Mishra, R., Gottschalk, S., Pal, R., Sim, N., Engelmann, J., …Parker, D. (2014). Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes

A series of bimodal metabotropic glutamate-receptor targeted MRI contrast agents has been developed and evaluated, based on established competitive metabotropic Glu receptor subtype 5 (mGluR5) antagonists. In order to directly visualize mGluR5 bindin... Read More about Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes.

Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells (2011)
Journal Article
Smith, D., Law, G., Benjamin, S., Pal, R., Parker, D., & Wong, K. (2011). Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells. Chemical Communications, 47(26), 7347-7349. https://doi.org/10.1039/c1cc11853f

Image and spectral intensity from bicarbonate-selective europium(III) probes localised in the mitochondria of cells is modulated reversibly by variation of external pCO2, and is suppressed by addition of the carbonic anhydrase inhibitor, acetazolomid... Read More about Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells.

Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes (2010)
Journal Article
New, E., Congreve, A., & Parker, D. (2010). Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes. Chemical Science, 1(1), 111-118. https://doi.org/10.1039/c0sc00105h

A series of experiments has been undertaken in order to gain a greater understanding of the cellular uptake and localisation behaviour of emissive lanthanide complexes as cellular stains or probes. Out of a large number of structurally related comple... Read More about Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes.

Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand. (2006)
Journal Article
Senanayake, K., Thompson, A., Howard, J., Botta, M., & Parker, D. (2006). Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand. Dalton Transactions, 5423-5428. https://doi.org/10.1039/b612189f

The macrocyclic ligand 1,4,7,10-tetraazacyclododecane-1,4,7-triyl(methylenebenzyl-phosphinic acid) H3L3, has been prepared and its complexes with Eu, Gd and Tb(III) studied by NMR, relaxometry, luminescence and single crystal X-ray crystallography. I... Read More about Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand..

A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants. (2006)
Journal Article
Poole, R., Kielar, F., Richardson, S., Stenson, P., & Parker, D. (2006). A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants. Chemical Communications, 2006(39), 4084-4086. https://doi.org/10.1039/b611259e

The excited states of Tb and Eu complexes of a common macrocyclic ligand are quenched preferentially by electron transfer from the urate anion, allowing the creation of a new assay to measure uric acid in biological fluids.

On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes (2006)
Journal Article
Thompson, A., Parker, D., Fulton, D., Howard, J., Pandya, S., Puschmann, H., Senanayake, K., Stenson, P., Badari, A., Botta, M., Avedano, S., & Aime, S. (2006). On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes. Dalton Transactions, 2006(47), 5605-5616. https://doi.org/10.1039/b606206g

The crystal structures of the hydrated salts of [Gd.DOTAM]3+ and its more hydrophobic derivative [Gd.2]3+, bearing 4 -phenylethyl groups, (both Gd and Yb salts) are reported and compared. The nature of the anion determines the degree of ordering in t... Read More about On the role of the counter-ion in defining water structure and dynamics : order, sructure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes.

A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment (2006)
Journal Article
Atkinson, P., Murray, B., & Parker, D. (2006). A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment. Organic and Biomolecular Chemistry, 4(16), 3166-3171. https://doi.org/10.1039/b608528h

The binding of two cationic europium complexes to a differentially phosphorylated insulin receptor peptide has been studied by emission spectroscopy and 31P NMR and 1H NMR TOCSY methods. Analysis of the europium emission and NMR spectral data was con... Read More about A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment.

Structural characterisation of a diprotonated ligand lanthanide complex - a key intermediate in lanthanide ion association and complex dissociation pathways (2006)
Journal Article
Stenson, P., Thompson, A., & Parker, D. (2006). Structural characterisation of a diprotonated ligand lanthanide complex - a key intermediate in lanthanide ion association and complex dissociation pathways. Dalton Transactions, 2006(27), 3291-3293. https://doi.org/10.1039/b605876k

The X-ray structure is reported of a diprotonated Gd(III) tetra-aqua complex of the ligand 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane (DOTAM), a thermodynamic intermediate in metal ion association and dissociation pathways.

Engineering emissive europium and terbium complexes for molecular imaging and sensing. (2006)
Journal Article
Pandya, S., Yu, J., & Parker, D. (2006). Engineering emissive europium and terbium complexes for molecular imaging and sensing. Dalton Transactions, 2006(23), 2757-2766. https://doi.org/10.1039/b514637b

Emissive f-block coordination complexes constitute an important class of optical probes, with applications ranging from sensing of bioactive species, high throughput assays and screening protocols in vitro, to time-resolved imaging studies in cellulo... Read More about Engineering emissive europium and terbium complexes for molecular imaging and sensing..

Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence (2006)
Journal Article
Atkinson, P., Findlay, K., Kielar, F., Pal, D., Parker, D., Poole, R., …Yu, J. (2006). Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence. Organic and Biomolecular Chemistry, 4(9), 1707-1722. https://doi.org/10.1039/b601357k

Several azaxanthone and azathioxanthone sensitising chromophores have been incorporated into macrocyclic ligands and form well-defined Eu and Tb complexes in polar media. Excitation of the heterocyclic chromophore in the range 330 to 382 nm leads to... Read More about Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence.

Glycoconjugates of gadolinium complexes for MRI applications. (2006)
Journal Article
Fulton, D., Elemento, E., Aime, S., Chaabane, L., Botta, M., & Parker, D. (2006). Glycoconjugates of gadolinium complexes for MRI applications. Chemical Communications, 2006(10), 1064-1066. https://doi.org/10.1039/b517997a

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional cou... Read More about Glycoconjugates of gadolinium complexes for MRI applications..

A europium complex that selectively stains nucleoli of cells (2006)
Journal Article
Yu, J., Parker, D., Pal, R., Poole, R., & Cann, M. (2006). A europium complex that selectively stains nucleoli of cells. Journal of the American Chemical Society, 128(7), 2294-2299. https://doi.org/10.1021/ja056303g

A europium complex selectively staining the nucleolus of NIH 3T3, HeLa, and HDF cells is reported. This complex possesses not only the advantage of the long lifetime of europium emission (0.3 ms), but also a chromophore that allows excitation at a re... Read More about A europium complex that selectively stains nucleoli of cells.