Skip to main content

Research Repository

Advanced Search

Different types of uncertainty in multisensory perceptual decision making (2023)
Journal Article
Aston, S., Nardini, M., & Beierholm, U. (2023). Different types of uncertainty in multisensory perceptual decision making. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1886), Article 20220349. https://doi.org/10.1098/rstb.2022.0349

Efficient decision-making requires accounting for sources of uncertainty (noise, or variability). Many studies have shown how the nervous system is able to account for perceptual uncertainty (noise, variability) that arises from limitations in its ow... Read More about Different types of uncertainty in multisensory perceptual decision making.

A peptide that regulates the metalation of the Arabidopsis ethylene receptor. (2023)
Journal Article
Mudge, A., Mehdi, S., Michaels, W., Orosa-Puente, B., Shen, W., Sadanandom, A., …Lindsey, K. (2023). A peptide that regulates the metalation of the Arabidopsis ethylene receptor. bioRxiv (Preprint Server for Biology), https://doi.org/10.1101/2023.06.15.545071

Ethylene signalling represents one of the classic hormonal pathways in plants, with diverse roles in development and stress responses. The dimeric ethylene receptor localizes to the endoplasmic reticulum (ER) and contains Cu(I) ions essential for eth... Read More about A peptide that regulates the metalation of the Arabidopsis ethylene receptor..

Multimorbidity due to novel pathogenic variants in theWFS1/RP1/NOD2genes: autosomal dominant congenital lamellar cataract, retinitis pigmentosa and Crohn’s disease in a British family (2023)
Journal Article
Berry, V., Ionides, A., Georgiou, M., Quinlan, R. A., & Michaelides, M. (2023). Multimorbidity due to novel pathogenic variants in theWFS1/RP1/NOD2genes: autosomal dominant congenital lamellar cataract, retinitis pigmentosa and Crohn’s disease in a British family. BMJ Open Ophthalmology, 8(1), Article e001252. https://doi.org/10.1136/bmjophth-2023-001252

Background A five generation family has been analysed by whole exome sequencing (WES) for genetic associations with the multimorbidities of congenital cataract (CC), retinitis pigmentosa (RP) and Crohn’s disease (CD). Methods WES was performed for un... Read More about Multimorbidity due to novel pathogenic variants in theWFS1/RP1/NOD2genes: autosomal dominant congenital lamellar cataract, retinitis pigmentosa and Crohn’s disease in a British family.

Naturally mutagenic sequence diversity in a human type II topoisomerase (2023)
Journal Article
Bandak, A., Blower, T., Nitiss, K., Gupta, R., Lau, A., Guha, R., …Berger, J. (2023). Naturally mutagenic sequence diversity in a human type II topoisomerase. Proceedings of the National Academy of Sciences, 120(28), Article e2302064120. https://doi.org/10.1073/pnas.2302064120

Type II topoisomerases transiently cleave duplex DNA as part of a strand passage mechanism that helps control chromosomal organization and superstructure. Aberrant DNA cleavage can result in genomic instability, and how topoisomerase activity is cont... Read More about Naturally mutagenic sequence diversity in a human type II topoisomerase.

Near atmospheric carbon dioxide activates plant ubiquitin cross-linking (2023)
Journal Article
Gannon, H. G., & Cann, M. J. (2023). Near atmospheric carbon dioxide activates plant ubiquitin cross-linking. https://doi.org/10.1016/j.bbadva.2023.100096

Background Identifying CO2-binding proteins is vital for our knowledge of CO2-regulated molecular processes. The carbamate post-translational modification is a reversible CO2-mediated adduct that can form on neutral N-terminal α-amino or lysine ε-ami... Read More about Near atmospheric carbon dioxide activates plant ubiquitin cross-linking.

Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix (2023)
Journal Article
Jarrin, M., Kalligeraki, A. A., Uwineza, A., Cawood, C. S., Brown, A. P., Ward, E. N., …Quinlan, R. A. (2023). Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix. Cells, https://doi.org/10.3390/cells12121580

Background: BFSP1 (beaded filament structural protein 1) is a plasma membrane, Aqua- 21 porin 0 (AQP0/MIP)-associated intermediate filament protein expressed in the eye lens. BFSP1 is 22 myristoylated, a post-translation modification that requires ca... Read More about Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix.

Sensory Augmentation for a Rapid Motor Task in a Multisensory Environment (2023)
Journal Article
Negen, J., Slater, H., & Nardini, M. (2023). Sensory Augmentation for a Rapid Motor Task in a Multisensory Environment. Restorative Neurology and Neuroscience, https://doi.org/10.3233/RNN-221279

Background: Sensory substitution and augmentation systems (SSASy) seek to either replace or enhance existing sensory skills by providing a new route to access information about the world. Tests of such systems have largely been limited to untimed, un... Read More about Sensory Augmentation for a Rapid Motor Task in a Multisensory Environment.

The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species (2023)
Journal Article
Macdonald, E., Wright, R., Connolly, J., Strahl, H., Brockhurst, M., van Houte, S., …Mariano, G. (2023). The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species. PLoS Genetics, 19(6), Article e1010784. https://doi.org/10.1371/journal.pgen.1010784

Competitive bacteria-bacteriophage interactions have resulted in the evolution of a plethora of bacterial defense systems preventing phage propagation. In recent years, computational and bioinformatic approaches have underpinned the discovery of nume... Read More about The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species.

Multisensory perception and decision-making with a new sensory skill (2023)
Journal Article
Negen, J., Bird, L., Slater, H., Thaler, L., & Nardini, M. (2023). Multisensory perception and decision-making with a new sensory skill. Journal of Experimental Psychology: Human Perception and Performance, 49(5), 600-622. https://doi.org/10.1037/xhp0001114

It is clear that people can learn a new sensory skill – a new way of mapping sensory inputs onto world states. It remains unclear how flexibly a new sensory skill can become embedded in multisensory perception and decision-making. To address this, we... Read More about Multisensory perception and decision-making with a new sensory skill.

Bubble Formation in Magma (2023)
Journal Article
Gardner, J. E., Wadsworth, F. B., Carley, T. L., Llewellin, E. W., Kusumaatmaja, H., & Sahagian, D. (2023). Bubble Formation in Magma. Annual Review of Earth and Planetary Sciences, 51(1), 131-154. https://doi.org/10.1146/annurev-earth-031621-080308

Volcanic eruptions are driven by bubbles that form when volatile species exsolve from magma. The conditions under which bubbles form depend mainly on magma composition, volatile concentration, presence of crystals, and magma decompression rate. These... Read More about Bubble Formation in Magma.

Pain through the perspective of art and creativity: insights from the Unmasking Pain project (2023)
Journal Article
Johnson, M. I., Chazot, P., Cole, F., Cruickshank, R., Fuller, D., Keyse, C., …Woodall, J. (2023). Pain through the perspective of art and creativity: insights from the Unmasking Pain project. Frontiers in Pain Research, 4, Article 1179116. https://doi.org/10.3389/fpain.2023.1179116

People struggle to tell their story of living with pain and when they do it is articulated in a way that may not be understood, heard or taken seriously. Unmasking Pain is an artist-led project that explored creative approaches to tell stories of lif... Read More about Pain through the perspective of art and creativity: insights from the Unmasking Pain project.

6-hour Training in click-based echolocation changes practice in visual impairment professionals (2023)
Journal Article
Thaler, L., Di Gregorio, G., & Foresteire, D. (2023). 6-hour Training in click-based echolocation changes practice in visual impairment professionals. Frontiers in Rehabilitation Sciences, https://doi.org/10.3389/fresc.2023.1098624

Click-based echolocation can support mobility and orientation in people with vision impairments (VI) when used alongside other mobility methods. Only a small number of people with VI use click-based echolocation. Previous research about echolocation... Read More about 6-hour Training in click-based echolocation changes practice in visual impairment professionals.

Spherical winding and helicity (2023)
Journal Article
Xiao, D., Prior, C., & Yeates, A. (2023). Spherical winding and helicity. Journal of Physics A: Mathematical and Theoretical, 56(20), Article 205201. https://doi.org/10.1088/1751-8121/accc17

In ideal magnetohydrodynamics, magnetic helicity is a conserved dynamical quantity and a topological invariant closely related to Gauss linking numbers. However, for open magnetic fields with non-zero boundary components, the latter geometrical inter... Read More about Spherical winding and helicity.

Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis (2023)
Journal Article
Sowerby, K., Freitag-Pohl, S., Murillo, A. M., Silber, A. M., & Pohl, E. (2023). Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Acta Crystallographica Section D: Structural Biology, 79(6), 518-530. https://doi.org/10.1107/s2059798323003613

Chagas disease is a neglected tropical disease (NTD) caused by Trypanosoma cruzi, whilst leishmaniasis, which is caused by over 20 species of Leishmania, represents a group of NTDs endemic to most countries in the tropical and subtropical belt of the... Read More about Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis.

Two Distinct Thermodynamic Gradients for Cellular Metalation of Vitamin B12 (2023)
Journal Article
Young, T. R., Deery, E., Foster, A. W., Martini, M. A., Osman, D., Warren, M. J., & Robinson, N. J. (2023). Two Distinct Thermodynamic Gradients for Cellular Metalation of Vitamin B12. JACS Au, 3(5), 1264-1534. https://doi.org/10.1021/jacsau.3c00119

The acquisition of CoII by the corrin component of vitamin B12 follows one of two distinct pathways, referred to as early or late CoII insertion. The late insertion pathway exploits a CoII metallochaperone (CobW) from the COG0523 family of G3E GTPase... Read More about Two Distinct Thermodynamic Gradients for Cellular Metalation of Vitamin B12.

The occipital place area is recruited for echo-acoustically guided navigation in blind human echolocators (2023)
Journal Article
Norman, L. J., & Thaler, L. (2023). The occipital place area is recruited for echo-acoustically guided navigation in blind human echolocators. Journal of Neuroscience, 43(24), 4470-4486. https://doi.org/10.1523/jneurosci.1402-22.2023

In the investigation of the brain areas involved in human spatial navigation, the traditional focus has been on visually guided navigation in sighted people. Consequently, it is unclear whether involved areas also support navigational abilities in ot... Read More about The occipital place area is recruited for echo-acoustically guided navigation in blind human echolocators.

Model of Friction with Plastic Contact Nudging: Amontons-Coulomb Laws, Aging of Static Friction, and Nonmonotonic Stribeck Curves with Finite Quasistatic Limit (2023)
Journal Article
Fielding, S. M. (2023). Model of Friction with Plastic Contact Nudging: Amontons-Coulomb Laws, Aging of Static Friction, and Nonmonotonic Stribeck Curves with Finite Quasistatic Limit. Physical Review Letters, 130(17), Article 178203. https://doi.org/10.1103/physrevlett.130.178203

We introduce a model of friction between two contacting (stationary or cosliding) rough surfaces, each comprising a random ensemble of polydisperse hemispherical bumps. In the simplest version of the model, the bumps experience on contact with each o... Read More about Model of Friction with Plastic Contact Nudging: Amontons-Coulomb Laws, Aging of Static Friction, and Nonmonotonic Stribeck Curves with Finite Quasistatic Limit.

Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis (2023)
Journal Article
Murray, J., Hodgson, D. R., & O’Donoghue, A. C. (2023). Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.2c02747

Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of rece... Read More about Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis.