All Outputs (84)

Phase modulation nanoscopy: a simple approach to enhanced optical resolution (2015)
Journal Article
Pal, R. (2015). Phase modulation nanoscopy: a simple approach to enhanced optical resolution. Faraday Discussions, 177, 507-515. https://doi.org/10.1039/c4fd00158c

A new modular super-resolution technique called Phase Modulation Nanoscopy (PhMoNa) has been developed in order to break the optical diffraction barrier in Confocal Laser Scanning Microscopy (LSCM). This technique is based on using spatially modulate... Read More about Phase modulation nanoscopy: a simple approach to enhanced optical resolution.

EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging (2014)
Journal Article
Butler, S., Delbianco, M., Lamarque, L., McMahon, B., Neil, E., Pal, R., …Zwier, J. (2015). EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging. Dalton Transactions, 44(11), 4791-4803. https://doi.org/10.1039/c4dt02785j

The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. St... Read More about EuroTracker® dyes : design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging.

Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo (2014)
Journal Article
Sim, N., Pal, R., Parker, D., Engelmann, J., Mishra, A., & Gottschalk, S. (2014). Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo. Organic and Biomolecular Chemistry, 12(46), 9389-9404. https://doi.org/10.1039/c4ob01848f

A second generation of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been synthesised and evaluated in cellulo, based on established bicyclic NMDA receptor antagonists. Their use as responsive MR imaging probes has been evalua... Read More about Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo.

Simple and versatile modifications allowing time gated spectral acquisition, imaging and lifetime profiling on conventional wide-field microscopes (2014)
Journal Article
Pal, R., & Beeby, A. (2014). Simple and versatile modifications allowing time gated spectral acquisition, imaging and lifetime profiling on conventional wide-field microscopes. Methods and Applications in Fluorescence, 2(3), Article 037001. https://doi.org/10.1088/2050-6120/2/3/037001

An inverted microscope has been adapted to allow time-gated imaging and spectroscopy to be carried out on samples containing responsive lanthanide probes. The adaptation employs readily available components, including a pulsed light source, time-gate... Read More about Simple and versatile modifications allowing time gated spectral acquisition, imaging and lifetime profiling on conventional wide-field microscopes.

Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes (2014)
Journal Article
Carr, R., Puckrin, R., McMahon, B. K., Pal, R., Parker, D., & Pålsson, L. (2014). Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes. Methods and Applications in Fluorescence, 2(2), Article 024007. https://doi.org/10.1088/2050-6120/2/2/024007

A circularly polarized luminescence (CPL) spectrometer has been built and used to study the binding interaction of lactate and four different proteins with racemic EuIII and TbIII complexes in aqueous solution. Lactate binding gives rise to strong in... Read More about Induced circularly polarized luminescence arising from anion or protein binding to racemic emissive lanthanide complexes.

Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes (2014)
Journal Article
Butler, S. J., Delbianco, M., Evans, N. H., Frawley, A. T., Pal, R., Parker, D., …Yufit, D. S. (2014). Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes. Dalton Transactions, 43(15), 5721-5730. https://doi.org/10.1039/c4dt00253a

The synthetic utility of europium complexes with three coordinated 4-bromopyridyl groups for chromophore elaboration has been assessed in palladium-catalysed Sonogashira coupling reactions, and in copper(I) mediated click reactions of the triazide de... Read More about Utility of tris(4-bromopyridyl) europium complexes as versatile intermediates in the divergent synthesis of emissive chiral probes.

EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging (2014)
Journal Article
Butler, S. J., Lamarque, L., Pal, R., & Parker, D. (2014). EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging. Chemical Science, 2014(5), 1750-1756. https://doi.org/10.1039/c3sc53056f

Nine very bright europium(III) complexes with different macrocyclic ligands have been prepared that exhibit excellent cell uptake behaviour and distinctive sub-cellular localisation profiles, allowing the use of fluorescence microscopy and time-gated... Read More about EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging.

Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy (2013)
Journal Article
Sim, N., Gottschalk, S., Pal, R., Engelmann, J., Parker, D., & Mishra, A. (2013). Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy. Chemical Science, 4(8), 3148-3153. https://doi.org/10.1039/c3sc50903f

Bright Mono-aqua Europium Complexes Based on Triazacyclononane That Bind Anions Reversibly and Permeate Cells Efficiently (2013)
Journal Article
Butler, S. J., McMahon, B. K., Pal, R., Parker, D., & Walton, J. W. (2013). Bright Mono-aqua Europium Complexes Based on Triazacyclononane That Bind Anions Reversibly and Permeate Cells Efficiently. Chemistry - A European Journal, 19(29), 9511-9517. https://doi.org/10.1002/chem.201301273

Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes (2013)
Other
Mishra, A., Mishra, R., Gottschalk, S., Pal, R., Sim, N., Engelmann, J., …Parker, D. (2014). Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes

A series of bimodal metabotropic glutamate-receptor targeted MRI contrast agents has been developed and evaluated, based on established competitive metabotropic Glu receptor subtype 5 (mGluR5) antagonists. In order to directly visualize mGluR5 bindin... Read More about Microscopic visualisation of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probes.

Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: direct formation of enantiopure systems for circularly polarised luminescence applications. (2013)
Journal Article
Evans, N. H., Carr, R., Delbianco, M., Pal, R., Yufit, D. S., & Parker, D. (2013). Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: direct formation of enantiopure systems for circularly polarised luminescence applications. Dalton Transactions, 42(44), 15610-6. https://doi.org/10.1039/c3dt52425f

Mono-C-substitution of the 1,4,7-triazacyclononane ring induces formation of single enantiomers of Eu(III) complexes with nonadentate N6O3 ligands. The absolute configuration of each complex is determined by the stereogenicity of the C-substituent, r... Read More about Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: direct formation of enantiopure systems for circularly polarised luminescence applications..

A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells. (2013)
Journal Article
McMahon, B. K., Pal, R., & Parker, D. (2013). A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells. Chemical Communications, 49(47), 5363-5365. https://doi.org/10.1039/c3cc42308e

A ratiometric EuIII complex has been developed that localises selectively within the endoplasmic reticulum of living cells. Careful calibration, using a time-gated spectral imaging microscope, allows the intensity ratio of emission bands and the vari... Read More about A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells..

Very bright europium complexes that stain cellular mitochondria. (2013)
Journal Article
Walton, J., Bourdoll, A., Butler, S., Soulie, M., Delbianco, M., McMahon, B., …Parker, D. (2013). Very bright europium complexes that stain cellular mitochondria. Chemical Communications, 49(16), 1600-1602. https://doi.org/10.1039/c2cc35247h

The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu em... Read More about Very bright europium complexes that stain cellular mitochondria..

Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes (2012)
Journal Article
Smith, D. G., McMahon, B. K., Pal, R., & Parker, D. (2012). Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes. Chemical Communications, 48(68), 8520-8522. https://doi.org/10.1039/c2cc34267g

Lanthanide Complexes Formed with the Tri- and Tetraacetate Derivatives of Bis(aminomethyl)phosphinic Acid: Equilibrium, Kinetic and NMR Spectroscopic Studies (2012)
Journal Article
Tircso, G., Kalman, F. K., Pal, R., Banyai, I., Varga, T. R., Kiraly, R., …Bruecher, E. (2012). Lanthanide Complexes Formed with the Tri- and Tetraacetate Derivatives of Bis(aminomethyl)phosphinic Acid: Equilibrium, Kinetic and NMR Spectroscopic Studies. European Journal of Inorganic Chemistry, 2062-2073. https://doi.org/10.1002/ejic.201101299

Analysis of citrate in low-volume seminal fluid samples using a time-gated measurement of europium luminescence (2011)
Journal Article
Pal, R., Beeby, A., & Parker, D. (2011). Analysis of citrate in low-volume seminal fluid samples using a time-gated measurement of europium luminescence. Journal of Pharmaceutical and Biomedical Analysis, 56(2), 352-358. https://doi.org/10.1016/j.jpba.2011.05.023

Cell-Penetrating Metal Complex Optical Probes: Targeted and Responsive Systems Based on Lanthanide Luminescence (2009)
Journal Article
Montgomery, C. P., Murray, B. S., New, E. J., Pal, R., & Parker, D. (2009). Cell-Penetrating Metal Complex Optical Probes: Targeted and Responsive Systems Based on Lanthanide Luminescence. Accounts of Chemical Research, 42(7), 925-937. https://doi.org/10.1021/ar800174z

Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing (2009)
Journal Article
Law, G., Pal, R., Palsson, L. O., Parker, D., & Wong, K. (2009). Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing. Chemical Communications, 7321-7323. https://doi.org/10.1039/b920222f

A europium luminescence assay of lactate and citrate in biological fluids (2009)
Journal Article
Pal, R., Parker, D., & Costello, L. C. (2009). A europium luminescence assay of lactate and citrate in biological fluids. Organic and Biomolecular Chemistry, 7(8), 1525-1528. https://doi.org/10.1039/b901251f

Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile (2008)
Journal Article
Murray, B. S., New, E. J., Pal, R., & Parker, D. (2008). Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile. Organic and Biomolecular Chemistry, 6(12), 2085-2094. https://doi.org/10.1039/b803895c