Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

Law, Ga-Lai; Pal, Robert; Palsson, Lars O.; Parker, David; Wong, Ka-Leung

Abstract

A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (ϕem 12%), allowing the creation of a ratiometric sensory system for pO2 (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

Citation

Law, G.-L., Pal, R., Palsson, L. O., Parker, D., & Wong, K.-L. (2009). Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing. Chemical Communications, 7321-7323. https://doi.org/10.1039/b920222f

• Journal Article Type: Article
• Acceptance Date: Oct 20, 2009
• Online Publication Date: Nov 2, 2009
• Publication Date: 2009
• Deposit Date: Mar 17, 2017
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Issue: 47
• Pages: 7321-7323
• DOI: https://doi.org/10.1039/b920222f
• Public URL: https://durham-repository.worktribe.com/output/1361963