Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Alastruey, Jordi; Charlton, Peter H.; Bikia, Vasiliki; Paliakaite, Birute; Hametner, Bernhard; Bruno, Rosa Maria; Mulder, Marijn P.; Vennin, Samuel; Piskin, Senol; Khir, Ashraf W.; Guala, Andrea; Mayer, Christopher C.; Mynard, Jonathan; Hughes, Alun D.; Segers, Patrick; Westerhof, Berend E.

Abstract

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We review the possibilities, limitations, complementarity, and differences of reduced-order, biophysical models of arterial PW propagation, as well as theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information for vascular age assessment. We provide detailed mathematical derivations of these models and theoretical methods, showing how they are related to each other. Finally, we outline directions for future research to realize the potential of modeling and analysis of PW signals for accurate assessment of vascular age in both the clinic and in daily life.

Citation

Alastruey, J., Charlton, P. H., Bikia, V., Paliakaite, B., Hametner, B., Bruno, R. M., …Westerhof, B. E. (2023). Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. American Journal of Physiology - Heart and Circulatory Physiology, 325(1), H1-H29. https://doi.org/10.1152/ajpheart.00705.2022

• Journal Article Type: Article
• Acceptance Date: Mar 27, 2023
• Online Publication Date: Mar 31, 2023
• Publication Date: Jul 1, 2023
• Deposit Date: Apr 10, 2024
• Publicly Available Date: Apr 10, 2024
• Journal: American Journal of Physiology-Heart and Circulatory Physiology
• Print ISSN: 0363-6135
• Electronic ISSN: 1522-1539
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 325
• Issue: 1
• Pages: H1-H29
• DOI: https://doi.org/10.1152/ajpheart.00705.2022
• Keywords: Physiology (medical); Cardiology and Cardiovascular Medicine; Physiology
• Public URL: https://durham-repository.worktribe.com/output/2381698