The importance of mosquito behavioural adaptations to malaria control in Africa

Gatton, M.; Chitnis, N.; Churcher, T.; Donnelly, M.J.; Ghani, A.C.; Godfray, C.J.; Gould, F.; Hastings, I.; Marshall, J.; Ranson, H.; Rowland, R.; Shaman, J.; Lindsay, S.W.

doi:10.1111/evo.12063

The importance of mosquito behavioural adaptations to malaria control in Africa

Gatton, M.; Chitnis, N.; Churcher, T.; Donnelly, M.J.; Ghani, A.C.; Godfray, C.J.; Gould, F.; Hastings, I.; Marshall, J.; Ranson, H.; Rowland, R.; Shaman, J.; Lindsay, S.W.

Authors

M. Gatton

N. Chitnis

T. Churcher

M.J. Donnelly

A.C. Ghani

C.J. Godfray

F. Gould

I. Hastings

J. Marshall

H. Ranson

R. Rowland

J. Shaman

Professor Steve Lindsay s.w.lindsay@durham.ac.uk
Professor

Abstract

Over the past decade the use of long-lasting insecticidal nets (LLINs), in combination with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helped reduce malaria in many African countries for the first time in a generation. However, insecticide resistance in the vector is an evolving threat to these gains. We review emerging and historical data on behavioral resistance in response to LLINs and IRS. Overall the current literature suggests behavioral and species changes may be emerging, but the data are sparse and, at times unconvincing. However, preliminary modeling has demonstrated that behavioral resistance could have significant impacts on the effectiveness of malaria control. We propose seven recommendations to improve understanding of resistance in malaria vectors. Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if we are to maintain the significant gains made in reducing malaria morbidity and mortality.

Citation

Gatton, M., Chitnis, N., Churcher, T., Donnelly, M., Ghani, A., Godfray, C., …Lindsay, S. (2013). The importance of mosquito behavioural adaptations to malaria control in Africa. Evolution: International Journal of Organic Evolution, 67(4), 1218-1230. https://doi.org/10.1111/evo.12063

Journal Article Type	Article
Publication Date	Apr 1, 2013
Deposit Date	Apr 10, 2013
Publicly Available Date	May 22, 2014
Journal	Evolution
Print ISSN	0014-3820
Electronic ISSN	1558-5646
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	67
Issue	4
Pages	1218-1230
DOI	https://doi.org/10.1111/evo.12063
Keywords	Anopheles, Indoor residual spraying, Insecticidal nets, Resistance.
Public URL	https://durham-repository.worktribe.com/output/1487639

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Copyright Statement
This is the peer reviewed version of the following article: Gatton, M.L., Chitnis, N., Churcher, T., Donnelly, M.J., Ghani, A.C., Godfray, H.C.J., Gould, F., Hastings, I., Marshall, J., Ranson, H., Rowland, M., Shaman, J. and Lindsay, S.W. (2013). The importance of mosquito behavioural adaptations to malaria control in Africa. Evolution 67(4): 1218-1230., which has been published in final form at http://dx.doi.org/10.1111/evo.12063. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.