The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review

Takken, Willem; Charlwood, Derek; Lindsay, Steve W.

Abstract

Background: Mosquitoes of the Anopheles gambiae complex are one of the major vectors of malaria in sub-Saharan Africa. Their ability to transmit this disease of major public health importance is dependent on their abundance, biting behaviour, susceptibility and their ability to survive long enough to transmit malaria parasites. A deeper understanding of this behaviour can be exploited for improving vector surveillance and malaria control. Findings: Adult mosquitoes emerge from aquatic habitats at dusk. After a 24 h teneral period, in which the cuticle hardens and the adult matures, they may disperse at random and search upwind for a mate or to feed. Mating generally takes place at dusk in swarms that form over species-specific ‘markers’. Well-nourished females may mate before blood-feeding, but the reverse is true for poorly-nourished insects. Females are monogamous and only mate once whilst males, that only feed on nectar, swarm nightly and can potentially mate up to four times. Females are able to locate hosts by following their carbon dioxide and odour gradients. When in close proximity to the host, visual cues, temperature and relative humidity are also used. Most blood-feeding occurs at night, indoors, with mosquitoes entering houses mainly through gaps between the roof and the walls. With the exception of the first feed, females are gonotrophically concordant and a blood meal gives rise to a complete egg batch. Egg development takes two or three days depending on temperature. Gravid females leave their resting sites at dusk. They are attracted by water gradients and volatile chemicals that provide a suitable aquatic habitat in which to lay their eggs. Conclusion: Whilst traditional interventions, using insecticides, target mosquitoes indoors, additional protection can be achieved using spatial repellents outdoors, attractant traps or house modifications to prevent mosquito entry. Future research on the variability of species-specific behaviour, movement of mosquitoes across the landscape, the importance of light and vision, reproductive barriers to gene flow, male mosquito behaviour and evolutionary changes in mosquito behaviour could lead to an improvement in malaria surveillance and better methods of control reducing the current over-reliance on the indoor application of insecticides.

Citation

Takken, W., Charlwood, D., & Lindsay, S. W. (2024). The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review. Malaria Journal, 23(1), Article 161. https://doi.org/10.1186/s12936-024-04982-3

• Journal Article Type: Article
• Acceptance Date: May 11, 2024
• Online Publication Date: May 23, 2024
• Publication Date: May 23, 2024
• Deposit Date: May 28, 2024
• Publicly Available Date: May 28, 2024
• Journal: Malaria Journal
• Electronic ISSN: 1475-2875
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 1
• Article Number: 161
• DOI: https://doi.org/10.1186/s12936-024-04982-3
• Keywords: Malaria surveillance, Mating, Malaria control, Hearing, Anopheles gambiae, Review, Behaviour, Olfaction, Oviposition, Taste, Vision
• Public URL: https://durham-repository.worktribe.com/output/2465905