Outputs (3)

Impact of the Physical Cellular Microenvironment on the Structure and Function of a Model Hepatocyte Cell Line for Drug Toxicity Applications (2023)
Journal Article
Allcock, B., Wei, W., Goncalves, K., Hoyle, H., Robert, A., Quelch-Cliffe, R., …Przyborski, S. (2023). Impact of the Physical Cellular Microenvironment on the Structure and Function of a Model Hepatocyte Cell Line for Drug Toxicity Applications. Cells, 12(19), Article 2408. https://doi.org/10.3390/cells12192408

It is widely recognised that cells respond to their microenvironment, which has implications for cell culture practices. Growth cues provided by 2D cell culture substrates are far removed from native 3D tissue structure in vivo. Geometry is one of ma... Read More about Impact of the Physical Cellular Microenvironment on the Structure and Function of a Model Hepatocyte Cell Line for Drug Toxicity Applications.

Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro (2022)
Journal Article
Hoyle, H., Stenger, C., & Przyborski, S. (2022). Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro. Biomaterials and biosystems, 8, Article 100063. https://doi.org/10.1016/j.bbiosy.2022.100063

One of the major aims of bio-engineering tissue equivalents in vitro is to create physiologically relevant culture conditions to accurately recreate the cellular microenvironment. This often includes incorporation of factors such as the extracellular... Read More about Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro.

Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues (2020)
Journal Article
Hoyle, H., Smith, L., Williams, R., & Przyborski, S. (2020). Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues. Interface Focus, 10(2), Article 20190090. https://doi.org/10.1098/rsfs.2019.0090

As the field of tissue engineering continues to advance rapidly, so too does the complexity of cell culture techniques used to generate in vitro tissue constructs, with the overall aim of mimicking the in vivo microenvironment. This complexity typica... Read More about Applications of novel bioreactor technology to enhance the viability and function of cultured cells and tissues.