Outputs (32)

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages (2023)
Journal Article
Porta, E. O., Gao, L., Denny, P. W., Steel, P. G., & Kalesh, K. (2023). Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages. Microbiology Spectrum, https://doi.org/10.1128/spectrum.02960-23

Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania, the etiological agent of the neglected... Read More about Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages.

Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana (2021)
Journal Article
Karunakaran, K., Sundriyal, S., Perera, H., Cobb, S. L., & Denny, P. W. (2021). Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana. mSystems, https://doi.org/10.1128/msystems.00089-21

Heat shock protein 90 (Hsp90) is a conserved molecular chaperone responsible for the folding and maturation of nascent proteins. Hsp90 is regarded as a master regulator of protein homeostasis in the cell, and its inhibition affects the functions of a... Read More about Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana.

How can proteomics overhaul our understanding of Leishmania biology? (2021)
Journal Article
Denny, P. W., & Karunakaran, K. (2021). How can proteomics overhaul our understanding of Leishmania biology?. Expert Review of Proteomics, https://doi.org/10.1080/14789450.2020.1885375

Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP7)‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages (2021)
Journal Article
Mantilla, B. S., Karunakaran, K., Brown, N. W., Fiedler, D., & Docampo, R. (2021). Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP7)‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages. Molecular Microbiology, 115(5), 986-1004. https://doi.org/10.1111/mmi.14672

Diphosphoinositol-5-pentakisphosphate (5-PP-IP5), also known as inositol heptakisphosphate (5-IP7), has been described as a high-energy phosphate metabolite that participates in the regulation of multiple cellular processes through protein binding or... Read More about Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP7)‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages.

Antileishmanial Drug Development: A Review of Modern Molecular Chemical Tools and Research Strategies (2020)
Journal Article
Mantravadi, P. K., Parthasarathy, A., & Karunakaran, K. (2020). Antileishmanial Drug Development: A Review of Modern Molecular Chemical Tools and Research Strategies. Current Medicinal Chemistry, https://doi.org/10.2174/0929867328666201125121018

Detectives and helpers: Natural products as resources for chemical probes and compound libraries (2020)
Journal Article
Parthasarathy, A., Mantravadi, P. K., & Karunakaran, K. (2020). Detectives and helpers: Natural products as resources for chemical probes and compound libraries. Pharmacology and Therapeutics, https://doi.org/10.1016/j.pharmthera.2020.107688

Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases (2020)
Journal Article
Parthasarathy, A., & Karunakaran, K. (2020). Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases. RSC Medicinal Chemistry, 11(6), 625-645. https://doi.org/10.1039/d0md00122h

Mass spectrometry-based proteomics enables accurate measurement of the modulations of proteins on a large scale upon perturbation and facilitates the understanding of the functional roles of proteins in biological systems. It is a particularly releva... Read More about Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases.

A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation (2019)
Journal Article
Karunakaran, K., & Denny, P. W. (2019). A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation. PLoS Neglected Tropical Diseases, 13(12), Article e0007651. https://doi.org/10.1371/journal.pntd.0007651

Adaptation to starvation is integral to the Leishmania life cycle. The parasite can survive prolonged periods of nutrient deprivation both in vitro and in vivo. The identification of parasite proteins synthesised during starvation is key to unravelli... Read More about A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation.

An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation (2019)
Journal Article
Karunakaran, K., Lukauskas, S., Borg, A. J., Snijders, A. P., Ayyappan, V., Leung, A. K., …DiMaggio, P. A. (2019). An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation. Scientific Reports, 9, Article 6655. https://doi.org/10.1038/s41598-019-43154-1

ADP-ribosylation is integral to a diverse range of cellular processes such as DNA repair, chromatin regulation and RNA processing. However, proteome-wide investigation of its cellular functions has been limited due to numerous technical challenges in... Read More about An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation.

The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies (2019)
Journal Article
Mantravadi, P., Karunakaran, K., Dobson, R., Hudson, A., & Parthasarathy, A. (2019). The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies. Antibiotics, 8(1), Article 8. https://doi.org/10.3390/antibiotics8010008

Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary processes of bacteria has led to this crisis. Only incremental a... Read More about The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies.

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action (2017)
Journal Article
Wong, Y. K., Xu, C., Kalesh, K. A., He, Y., Lin, Q., Wong, W. F., …Wang, J. (2017). Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action. Medicinal Research Reviews, 37(6), https://doi.org/10.1002/med.21446

The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations (2017)
Journal Article
Parthasarathy, A., Anandamma, S. K., & Kalesh, K. A. (2017). The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations. Current Medicinal Chemistry, 24, https://doi.org/10.2174/0929867324666171012103559

Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications (2017)
Journal Article
Ong, Y. S., Gao, L., Kalesh, K. A., Yu, Z., Wang, J., Liu, C., …Lee, S. S. (2017). Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications. Current Topics in Medicinal Chemistry, 17(20), https://doi.org/10.2174/1568026617666170224121658

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane (2017)
Journal Article
Clulow, J. A., Storck, E. M., Lanyon-Hogg, T., Kalesh, K. A., Jones, L. H., & Tate, E. W. (2017). Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications, 53(37), 5182-5185. https://doi.org/10.1039/c6cc08797c

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify o... Read More about Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Target identification of natural and traditional medicines with quantitative chemical proteomics approaches (2016)
Journal Article
Wang, J., Gao, L., Lee, Y. M., Kalesh, K. A., Ong, Y. S., Lim, J., …Lin, Q. (2016). Target identification of natural and traditional medicines with quantitative chemical proteomics approaches. Pharmacology and Therapeutics, 162, https://doi.org/10.1016/j.pharmthera.2016.01.010

A capillary electrophoresis method to explore the self-assembly of a novel polypeptide ligand with quantum dots (2016)
Journal Article
Wang, J., Zhang, C., Liu, L., Kalesh, K. A., Qiu, L., Ding, S., …Jiang, P. (2016). A capillary electrophoresis method to explore the self-assembly of a novel polypeptide ligand with quantum dots. ELECTROPHORESIS, 37(15-16), https://doi.org/10.1002/elps.201600164

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1 (2016)
Journal Article
Cioffi, C. L., Liu, S., Wolf, M. A., Guzzo, P. R., Sadalapure, K., Parthasarathy, V., …Mhyre, A. J. (2016). Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1. Journal of Medicinal Chemistry, 59(18), 8473-8494. https://doi.org/10.1021/acs.jmedchem.6b00914

Global profiling of protein lipidation using chemical proteomic technologies (2015)
Journal Article
Tate, E. W., Kalesh, K. A., Lanyon-Hogg, T., Storck, E. M., & Thinon, E. (2015). Global profiling of protein lipidation using chemical proteomic technologies. Current Opinion in Chemical Biology, 24, https://doi.org/10.1016/j.cbpa.2014.10.016

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics (2015)
Journal Article
Kalesh, K. A., Clulow, J. A., & Tate, E. W. (2015). Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics. Chemical Communications, 51(25), 5497-5500. https://doi.org/10.1039/c4cc09527h

A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5 (2014)
Journal Article
Kalesh, K. A., & Tate, E. W. (2014). A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5. Organic and Biomolecular Chemistry, 12(25), https://doi.org/10.1039/c4ob00773e

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer (2012)
Journal Article
Prasannan, R., Kalesh, K. A., Shanmugam, M. K., Nachiyappan, A., Ramachandran, L., Nguyen, A. H., …Sethi, G. (2012). Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer. Biochemical Pharmacology, 84(10), https://doi.org/10.1016/j.bcp.2012.07.015

Synthesis of 2,3,5-trisubstituted furans from α-formylaroylketene dithioacetals (2011)
Journal Article
Sasikala, K., Kalesh, K., Anabha, E., Pillai, P. M., Asokan, C., & Devaky, K. (2011). Synthesis of 2,3,5-trisubstituted furans from α-formylaroylketene dithioacetals. Tetrahedron Letters, 52(14), https://doi.org/10.1016/j.tetlet.2011.01.128

The use of click chemistry in the emerging field of catalomics (2010)
Journal Article
Kalesh, K. A., Shi, H., Ge, J., & Yao, S. Q. (2010). The use of click chemistry in the emerging field of catalomics. Organic and Biomolecular Chemistry, 8(8), https://doi.org/10.1039/b923331h

Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs) (2010)
Journal Article
Kalesh, K. A., Tan, L. P., Lu, K., Gao, L., Wang, J., & Yao, S. Q. (2010). Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs). Chemical Communications, 46(4), https://doi.org/10.1039/b919744c

Small molecule probes that target Ablkinase (2010)
Journal Article
Kalesh, K. A., Sim, D. S., Wang, J., Liu, K., Lin, Q., & Yao, S. Q. (2010). Small molecule probes that target Ablkinase. Chemical Communications, 46(7), https://doi.org/10.1039/b919888a

High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening (2009)
Journal Article
Srinivasan, R., Tan, L. P., Wu, H., Yang, P., Kalesh, K. A., & Yao, S. Q. (2009). High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening. Organic and Biomolecular Chemistry, 7(9), https://doi.org/10.1039/b902338k

High-Throughput Discovery ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry (2009)
Journal Article
Tan, L. P., Wu, H., Yang, P., Kalesh, K. A., Zhang, X., Hu, M., …Yao, S. Q. (2009). High-Throughput Discovery ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry. Organic Letters, 11(22), https://doi.org/10.1021/ol9023419

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry (2009)
Journal Article
Kalesh, K. A., Liu, K., & Yao, S. Q. (2009). Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry. Organic and Biomolecular Chemistry, 7(24), https://doi.org/10.1039/b913333j

An Improved Mechanism-Based Cross-Linker for Multiplexed Kinase Detection and Inhibition in a Complex Proteome (2008)
Journal Article
Liu, K., Kalesh, K. A., Bing Ong, L., & Yao, S. Q. (2008). An Improved Mechanism-Based Cross-Linker for Multiplexed Kinase Detection and Inhibition in a Complex Proteome. ChemBioChem, 9(12), https://doi.org/10.1002/cbic.200800212

Methods of using click chemistry in the discovery of enzyme inhibitors (2007)
Journal Article
Srinivasan, R., Li, J., Ng, S. L., Kalesh, K. A., & Yao, S. Q. (2007). Methods of using click chemistry in the discovery of enzyme inhibitors. Nature Protocols, 2(11), https://doi.org/10.1038/nprot.2007.323

Click Chemistry as a High-Throughput Amenable Platform in Catalomics (2007)
Journal Article
Kalesh, K., Yang, P., Srinivasan, R., & Yao, S. (2007). Click Chemistry as a High-Throughput Amenable Platform in Catalomics. QSAR & combinatorial science (Internet), 26(11-12), https://doi.org/10.1002/qsar.200740064

Nanoparticles-chemistry, new synthetic approaches, gas phase clustering and novel applications (2005)
Journal Article
Nair, A. S., Subramaniam, C., Rosemary, M., Tom, R. T., Kumar, V. R., Singh, D. D. J., …Pradeep, T. (2005). Nanoparticles-chemistry, new synthetic approaches, gas phase clustering and novel applications. Pramana - Journal of Physics, 65(4), https://doi.org/10.1007/bf03010451