Skip to main content

Research Repository

Advanced Search

Outputs (48)

A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean (2024)
Journal Article
Sanderson, D. J. (2024). A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean. Cognition, 247, Article 105770. https://doi.org/10.1016/j.cognition.2024.105770

The temporal bisection procedure has been used to assess theories of time perception. A problem with the procedure for measuring the perceived midpoint of two durations is that the spacing of probe durations affects the length of the bisection point.... Read More about A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean.

Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice (2023)
Journal Article
Strickland, J., Austen, J., Sprengel, R., & Sanderson, D. (2024). Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice. Hippocampus, 34(3), 126-140. https://doi.org/10.1002/hipo.23593

The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for learning about tim... Read More about Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice.

Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience (2022)
Journal Article

Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic... Read More about Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.

Reinforcement rate and the balance between excitatory and inhibitory learning: insights from deletion of the GluA1 AMPA receptor subunit (2022)
Journal Article

Conditioned responding is sensitive to reinforcement rate. This rate-sensitivity is impaired in genetically modified mice that lack the GluA1 subunit of the AMPA receptor. A time-dependent application of the Rescorla–Wagner learning rule can be used... Read More about Reinforcement rate and the balance between excitatory and inhibitory learning: insights from deletion of the GluA1 AMPA receptor subunit.

Dissociating representations of time and number in reinforcement rate learning by GluA1 AMPAR subunit deletion in mice (2021)
Journal Article

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational v... Read More about Dissociating representations of time and number in reinforcement rate learning by GluA1 AMPAR subunit deletion in mice.

Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions (2020)
Journal Article

We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive obj... Read More about Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions.

The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled (2019)
Journal Article

NMDA receptor-dependent synaptic plasticity has been proposed to be important for encoding of memories. Consistent with this hypothesis, the non-competitive NMDA receptor antagonist, MK-801, has been found to impair performance on tests of memory. In... Read More about The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled.

Continual trials spontaneous recognition tasks in mice: reducing animal numbers and improving our understanding of the mechanisms underlying memory (2018)
Journal Article

Spontaneous recognition tasks are widely used as a laboratory measure of memory in animals but give rise to high levels of behavioural noise leading to a lack of reliability. Previous work has shown that a modification of the procedure to allow conti... Read More about Continual trials spontaneous recognition tasks in mice: reducing animal numbers and improving our understanding of the mechanisms underlying memory.

Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms (2018)
Journal Article

Pathological over-activity of the CA1 subfield of the human anterior hippocampus has been identified as a potential predictive marker for transition from a prodromal state to overt schizophrenia. Psychosis, in turn, is associated with elevated activi... Read More about Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms.

GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact (2017)
Journal Article

The GluA1 subunit of the AMPA receptor has been implicated in schizophrenia. While GluA1 is important for cognition, it is not clear what the role of GluA1 is in hedonic responses that are relevant to the negative symptoms of disorders such as schizo... Read More about GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.

Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia (2017)
Journal Article

The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that i... Read More about Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia.

The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice (2017)
Journal Article

Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-D-as... Read More about The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.

Contexts control negative contrast and restrict the expression of flavor preference conditioning (2016)
Journal Article
Austen, J. M., & Sanderson, D. J. (2016). Contexts control negative contrast and restrict the expression of flavor preference conditioning. Journal of Experimental Psychology: Animal Learning and Cognition, 42, 95-105. https://doi.org/10.1037/xan0000091

Consumption of a high concentration of sucrose can have either a detrimental, negative contrast effect or a facilitatory, preference conditioning effect on subsequent consumption of a low concentration of sucrose, depending on the cues that are prese... Read More about Contexts control negative contrast and restrict the expression of flavor preference conditioning.

Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium (2015)
Journal Article
Davis, D. H. J., Skelly, D. .., Murray, C., Hennessy, E., Bowen, J., Norton, S., …Cunningham, C. (2015). Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. American Journal of Geriatric Psychiatry, 23(4), 403-415. https://doi.org/10.1016/j.jagp.2014.08.005

Background: Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired versus cognitively normal) with... Read More about Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium.

What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit (2014)
Journal Article

The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, th... Read More about What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit.

Hippocampal synaptic plasticity, spatial memory and anxiety (2014)
Journal Article
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014). Hippocampal synaptic plasticity, spatial memory and anxiety. Nature Reviews Neuroscience, 15(3), 181-192. https://doi.org/10.1038/nrn3677

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories.... Read More about Hippocampal synaptic plasticity, spatial memory and anxiety.

Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion (2012)
Journal Article
Bannerman, D. M., Bus, T., Taylor, A., Sanderson, D. J., Schwarz, I., Jenson, V., …Sprengel, R. (2012). Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion. Nature Neuroscience, 15(8), 1153-1159. https://doi.org/10.1038/nn.3166

Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are widely considered crucial substrates of long-term spatial memory, although their precise role remains uncertain. Here we show that Grin1ΔDGCA1 mice, lacking GluN1 and hen... Read More about Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.

Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information (2012)
Journal Article
Sanderson, D. J., Rawlins, J. N. P., Deacon, R. M. J., Cunningham, C., Barkus, C., & Bannerman, D. M. (2012). Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information. Hippocampus, 22(7), 1553-1566. https://doi.org/10.1002/hipo.20995

Spatial properties of stimuli are sometimes encoded even when incidental to the demands of a particular learning task. Incidental encoding of spatial information may interfere with learning by (i) causing a failure to generalize learning between tria... Read More about Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information.

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium (2012)
Journal Article
Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C. (2012). Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiology of Aging, 33(3), 603-616. https://doi.org/10.1016/j.neurobiolaging.2010.04.002

Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infections. Delirium is poorly understood and the lack of biologi... Read More about Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder (2012)
Journal Article
Barkus, C., Feyder, M., Graybeal, C., Wright, T., Wiedholz, L., Izquierdo, A., …Holmes, A. (2012). Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder. Neuropharmacology, 62(3), 1263-1272. https://doi.org/10.1016/j.neuropharm.2011.06.005

The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice (2012)
Journal Article
Sanderson, D. J., & Bannerman, D. M. (2012). The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice. Hippocampus, 22(5), 981-994. https://doi.org/10.1002/hipo.20896

Spatial alternation, win-shift behavior has been claimed to be a test of working memory in rodents that requires active maintenance of relevant, trial-specific information. In this review, we describe work with GluA1 AMPA receptor subunit knockout mi... Read More about The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice.

Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice (2011)
Journal Article
Taylor, A. M., Niewoehner, B., Seeburg, P. H., Sprengel, R., Rawlins, J. N. P., Bannerman, D. M., & Sanderson, D. J. (2011). Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behavioural Brain Research, 224(1), 8-14. https://doi.org/10.1016/j.bbr.2011.05.016

GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in... Read More about Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.

Competitive short-term and long-term memory processes in spatial habituation (2011)
Journal Article
Sanderson, D. J., & Bannerman, D. M. (2011). Competitive short-term and long-term memory processes in spatial habituation. Journal of experimental psychology. Animal behavior processes, 37(2), 189-199. https://doi.org/10.1037/a0021461

Exposure to a spatial location leads to habituation of exploration such that, in a novelty preference test, rodents subsequently prefer exploring a novel location to the familiar location. According to Wagner's (1981) theory of memory, short-term and... Read More about Competitive short-term and long-term memory processes in spatial habituation.

Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory (2011)
Journal Article
Sanderson, D. J., Hindley, E., Smeaton, E., Denny, N., Taylor, A., Barkus, C., …Bannerman, D. M. (2011). Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory. Learning & Memory, 18(3), 181-190. https://doi.org/10.1101/lm.2083411

Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory. It has been suggested that short-term recognition depends upon memory caused by the recent presentation of a stimulus that is independent of contextual–retriev... Read More about Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory.

Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner’s dual-process memory model (2010)
Journal Article
Sanderson, D. J., McHugh, S. B., Good, M. A., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P., & Bannerman, D. M. (2010). Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner’s dual-process memory model. Neuropsychologia, 48(8), 2303-2315. https://doi.org/10.1016/j.neuropsychologia.2010.03.018

Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model (2009)
Journal Article
Sanderson, D. J., Good, M. A., Skelton, K., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P., & Bannerman, D. M. (2009). Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model. Learning & Memory, 16(6), 379-386. https://doi.org/10.1101/lm.1339109

The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation. GluA1 gene deletion impairs hippocampus-dependent, spatial working memory, but... Read More about Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model.