David Parker's Outputs (6)

Versatile Para‐Substituted Pyridine Lanthanide Coordination Complexes Allow Late Stage Tailoring of Complex Function (2021)
Journal Article
Starck, M., Fradgley, J. D., De Rosa, D. F., Batsanov, A. S., Papa, M., Taylor, M. J., Lovett, J. E., Lutter, J. C., Allen, M. J., & Parker, D. (2021). Versatile Para‐Substituted Pyridine Lanthanide Coordination Complexes Allow Late Stage Tailoring of Complex Function. Chemistry - A European Journal, 27(71), 17921-17927. https://doi.org/10.1002/chem.202103243

A series of cationic and neutral p−Br and p−NO2 pyridine substituted Eu(III) and Gd(III) coordination complexes serve as versatile synthetic intermediates. Nucleophilic aromatic substitution occurs readily at the para position under mild conditions,... Read More about Versatile Para‐Substituted Pyridine Lanthanide Coordination Complexes Allow Late Stage Tailoring of Complex Function.

Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes (2021)
Journal Article
Parker, D., Fradgley, J. D., Delbianco, M., Starck, M., Walton, J., & Zwier, J. M. (2022). Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes. Faraday Discussions, 234, 159 - 174. https://doi.org/10.1039/d1fd00059d

The relative sensitivities of structurally related Eu(III) complexes to quenching by electron and energy transfer processes have been compared. In two sets of 9-coordinate complexes based on 1,4,7-triazacyclononane, the Eu emission lifetime decreased... Read More about Comparative analysis of lanthanide excited state quenching by electronic energy and electron transfer processes.

The design of responsive luminescent lanthanide probes and sensors (2021)
Journal Article
Parker, D., Fradgley, J. D., & Wong, K.-L. (2021). The design of responsive luminescent lanthanide probes and sensors. Chemical Society Reviews, 50(14), 8193-8213. https://doi.org/10.1039/d1cs00310k

The principles of the design of responsive luminescent probes and sensors based on lanthanide emission are summarised, based on a mechanistic understanding of their mode of action. Competing kinetic pathways for deactivation of the excited states tha... Read More about The design of responsive luminescent lanthanide probes and sensors.

Targeted pH switched europium complexes monitoring receptor internalisation in living cells (2021)
Journal Article
Fradgley, J. D., Starck, M., Laget, M., Bourrier, E., Dupuis, E., Lamarque, L., Trinquet, E., Zwier, J. M., & Parker, D. (2021). Targeted pH switched europium complexes monitoring receptor internalisation in living cells. Chemical Communications, 57(47), 5814-5817. https://doi.org/10.1039/d1cc01029h

We report the design and evaluation of pH responsive luminescent europium(III) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to m... Read More about Targeted pH switched europium complexes monitoring receptor internalisation in living cells.

Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field (2021)
Journal Article
Fradgley, J. D., Frawley, A. T., Pal, R., & Parker, D. (2021). Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field. Physical Chemistry Chemical Physics, 23(19), 11479-11487. https://doi.org/10.1039/d1cp01686e

Examination of total emission and circularly polarised luminescence (CPL) spectra of three 9-coordinate Eu(III) complexes with well-defined speciation shows that the ligand fields of these C3 symmetric complexes are extremely sensitive to solvent pol... Read More about Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field.

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging (2021)
Journal Article
Zhang, Y., Ma, X., Chau, H.-F., Thor, W., Jiang, L., Zha, S., Fok, W.-Y., Mak, H.-N., Zhang, J., Cai, J., Ng, C.-F., Li, H., Parker, D., Li, L., Law, G.-L., & Wong, K.-L. (2021). Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging. ACS Applied Nano Material, 4(1), 271-278. https://doi.org/10.1021/acsanm.0c02597

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lant... Read More about Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging.