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Outputs (28)

Rapid measurement of ageing by automated monitoring of movement of C. elegans populations (2023)
Journal Article
Zavagno, G., Raimundo, A., Kirby, A., Saunter, C., & Weinkove, D. (2023). Rapid measurement of ageing by automated monitoring of movement of C. elegans populations. GeroScience, https://doi.org/10.1007/s11357-023-00998-w

Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorhabditis elegans offers a rapid in vivo method to determine whether a compound extends its 2 to 3-week lifespan. Measuring lifesp... Read More about Rapid measurement of ageing by automated monitoring of movement of C. elegans populations.

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans (2022)
Journal Article
Reigada, I., Kapp, K., Maynard, C., Weinkove, D., Valero, M. S., Langa, E., …Gómez-Rincón, C. (2022). Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans. Nutrients, 14(9), Article 1986. https://doi.org/10.3390/nu14091986

Guarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbiota have not been studied. Caenorhabditis elegans is a useful mod... Read More about Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans.

Applying C. elegans to the Industrial Drug Discovery Process to Slow Aging (2021)
Journal Article
Weinkove, D., & Zavagno, G. (2021). Applying C. elegans to the Industrial Drug Discovery Process to Slow Aging. Frontiers in Aging, 2, Article 740582. https://doi.org/10.3389/fragi.2021.740582

The increase in our molecular understanding of the biology of aging, coupled with a recent surge in investment, has led to the formation of several companies developing pharmaceuticals to slow aging. Research using the tiny nematode worm Caenorhabdit... Read More about Applying C. elegans to the Industrial Drug Discovery Process to Slow Aging.

Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems (2021)
Journal Article
Les, F., Valero, M. S., Moliner, C., Weinkove, D., López, V., & Gómez-Rincón, C. (2021). Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems. Biology, 10(5), Article 443. https://doi.org/10.3390/biology10050443

In traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated... Read More about Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems.

Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety (2021)
Journal Article
Tataridas-Pallas, N., Thompson, M. A., Howard, A., Brown, I., Ezcurra, M., Wu, Z., …Tullet, J. M. (2021). Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety. PLoS Genetics, 17(3), Article e1009358. https://doi.org/10.1371/journal.pgen.1009358

The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense foo... Read More about Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.

Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans (2020)
Journal Article
Maynard, C., & Weinkove, D. (2020). Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans. Genes & Nutrition, 15, Article 4. https://doi.org/10.1186/s12263-020-00662-4

Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but the contribution of these compounds to to... Read More about Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans.

On microbes, aging and the worm: an interview with David Weinkove (2018)
Journal Article
Weinkove, D. (2018). On microbes, aging and the worm: an interview with David Weinkove. BMC Biology, 16(1), Article 125. https://doi.org/10.1186/s12915-018-0600-x

David Weinkove is an associate professor at Durham University, UK, studying host–microbe interactions in the model organism Caenorhabditis elegans. David has been focusing on the way microbes affect the physiology of their hosts, including the proces... Read More about On microbes, aging and the worm: an interview with David Weinkove.

A bacterial route for folic acid supplementation (2018)
Journal Article
Maynard, C., Cummins, I., Green, J., & Weinkove, D. (2018). A bacterial route for folic acid supplementation. BMC Biology, 16, Article 67. https://doi.org/10.1186/s12915-018-0534-3

Background: To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolism and uptake. Notably, safety... Read More about A bacterial route for folic acid supplementation.

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy (2018)
Journal Article
Lundquist, M. R., Goncalves, M. D., Loughran, R. M., Possik, E., Vijayaraghavan, T., Yang, A., …Emerling, B. M. (2018). Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular Cell, 70(3), 531-544.e9. https://doi.org/10.1016/j.molcel.2018.03.037

While the majority of phosphatidylinositol-4, 5-bisphosphate (PI-4, 5-P2) in mammalian cells is generated by the conversion of phosphatidylinositol-4-phosphate (PI-4-P) to PI-4, 5-P2, a small fraction can be made by phosphorylating phosphatidylinosit... Read More about Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis (2016)
Journal Article
Virk, B., Jia, J., Maynard, C., Raimundo, A., Lefebvre, J., Richards, S., …Weinkove, D. (2016). Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis. Cell Reports, 14(7), 1611-1620. https://doi.org/10.1016/j.celrep.2016.01.051

Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. el... Read More about Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis.

Model Super-organisms: Can the biochemical genetics of E. coli help us understand aging? (2015)
Other
Weinkove, D. (2015). Model Super-organisms: Can the biochemical genetics of E. coli help us understand aging?

Escherichia coli is a powerful model organism to help us understand biochemical pathways and enzyme function. In E. coli, biosynthetic pathway mutants are conditionally viable depending on the composition of the nutrient media. Genetic analysis allow... Read More about Model Super-organisms: Can the biochemical genetics of E. coli help us understand aging?.

Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children (2015)
Journal Article
Zhang, C., Yin, A., Li, H., Wang, R., Wu, G., Shen, J., …Zhao, L. (2015). Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children. EBioMedicine, 2(8), 968-984. https://doi.org/10.1016/j.ebiom.2015.07.007

Gut microbiota has been implicated as a pivotal contributing factor in diet-related obesity; however, its role in development of disease phenotypes in human genetic obesity such as Prader–Willi syndrome (PWS) remains elusive. In this hospitalized int... Read More about Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.

From aging worms to the influence of the microbiota: an interview with David Weinkove (2013)
Journal Article
Weinkove, D. (2013). From aging worms to the influence of the microbiota: an interview with David Weinkove. BMC Biology, 11, https://doi.org/10.1186/1741-7007-11-94

David Weinkove did his undergraduate degree at Cambridge, then a PhD at University College London with Mike Waterfield and Sally Leevers. His first postdoctoral position was with Ronald Plasterk at the Hubrecht Laboratory in the Netherlands, followed... Read More about From aging worms to the influence of the microbiota: an interview with David Weinkove.

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism (2013)
Journal Article
Cabreiro, F., Au, C., Leung, K., Vergara-Irigaray, N., Cochemé, H., Noori, T., …Gems, D. (2013). Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell, 153(1), 228-239. https://doi.org/10.1016/j.cell.2013.02.035

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium... Read More about Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model (2012)
Journal Article
Virk, B., Correia, G., Dixon, D., Feyst, I., Jia, J., Oberleitner, N., …Weinkove, D. (2012). Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model. BMC Biology, 10(1), Article 67. https://doi.org/10.1186/1741-7007-10-67

Background: Gut microbes influence animal health and thus, are potential targets for interventions that slow aging. Live E. coli provides the nematode worm Caenorhabditis elegans with vital micronutrients, such as folates that cannot be synthesized b... Read More about Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults (2008)
Journal Article
Weinkove, D., Bastiani, M., Chessa, T., Joshi, D., Hauth, L., Cooke, F., …Schuske, K. (2008). Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Developmental Biology, 313(1), 384-397. https://doi.org/10.1016/j.ydbio.2007.10.029

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm (2006)
Journal Article
Weinkove, D., Halstead, J., Gems, D., & Divecha, N. (2006). Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biology, 4, Article 1. https://doi.org/10.1186/1741-7007-4-1

Background: The provision of stress resistance diverts resources from development and reproduction and must therefore be tightly regulated. In Caenorhabditis elegans, the switch to increased stress resistance to promote survival through periods of st... Read More about Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm.