All Outputs (2)

Synthesis of Novel Steroidal Inhibitors of HIV-1 Protease (1998)
Journal Article
Harburn, J., Loftus, G., & Marples, B. (1998). Synthesis of Novel Steroidal Inhibitors of HIV-1 Protease. Tetrahedron, 54(39), 11907-11924. https://doi.org/10.1016/s0040-4020%2898%2900699-1

The design and synthesis of potential steroidal HIV-1 protease inhibitors is described. Compounds derived from 11-amino-12-keto-cholanic acid derivatives show modest activity.

Steroid A-Ring Aromatisation of C-Ring Substituted 1,4-dien-3-ones (1998)
Journal Article
Harburn, J., Loftus, G., & Marples, B. (1998). Steroid A-Ring Aromatisation of C-Ring Substituted 1,4-dien-3-ones. Journal of Chemical Research, 8, 424-425. https://doi.org/10.1039/a802562b

A number of A-ring steroidal 1,4-dien-3-ones 7, 8, 9 and 10 have been aromatised in zinc/pyridine–water; the products depend upon the position and type of C-ring substituents and provide new evidence in support of a radical anion mechanism.