Synthesis of Novel Steroidal Inhibitors of HIV-1 Protease

Harburn, J.J; Loftus, G.C; Marples, B.A

Abstract

The design and synthesis of potential steroidal HIV-1 protease inhibitors is described. Compounds derived from 11-amino-12-keto-cholanic acid derivatives show modest activity.

Citation

Harburn, J., Loftus, G., & Marples, B. (1998). Synthesis of Novel Steroidal Inhibitors of HIV-1 Protease. Tetrahedron, 54(39), 11907-11924. https://doi.org/10.1016/s0040-4020%2898%2900699-1

• Journal Article Type: Article
• Publication Date: Sep 1, 1998
• Deposit Date: Nov 19, 2012
• Journal: Tetrahedron
• Print ISSN: 0040-4020
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 54
• Issue: 39
• Pages: 11907-11924
• DOI: https://doi.org/10.1016/s0040-4020%2898%2900699-1
• Public URL: https://durham-repository.worktribe.com/output/1471880