Diastereoselective Trifluoroacetylation of Highly Substituted Pyrrolidines by a DakinWest Process
(2016)
Journal Article
Baumann, M., & Baxendale, I. (2016). Diastereoselective Trifluoroacetylation of Highly Substituted Pyrrolidines by a DakinWest Process. Journal of Organic Chemistry, 81(23), 11898-11908. https://doi.org/10.1021/acs.joc.6b02346
All Outputs (6)
Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant (2016)
Journal Article
Mallia, C., Burton, P., Smith, A., Walter, G., & Baxendale, I. (2016). Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant. Beilstein Journal of Organic Chemistry, 12, 1598-1607. https://doi.org/10.3762/bjoc.12.156A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas react... Read More about Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant.
Flow carbonylation of sterically hindered ortho-substituted iodoarenes (2016)
Journal Article
Mallia, C., Walter, G., & Baxendale, I. (2016). Flow carbonylation of sterically hindered ortho-substituted iodoarenes. Beilstein Journal of Organic Chemistry, 12, 1503-1511. https://doi.org/10.3762/bjoc.12.147The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palla... Read More about Flow carbonylation of sterically hindered ortho-substituted iodoarenes.
Exploring Flow Procedures for Diazonium Formation (2016)
Journal Article
Hu, T., Baxendale, I., & Baumann, M. (2016). Exploring Flow Procedures for Diazonium Formation. Molecules, 21(7), Article 918. https://doi.org/10.3390/molecules21070918The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions incl... Read More about Exploring Flow Procedures for Diazonium Formation.
The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis (2016)
Journal Article
Filipponi, P., & Baxendale, I. (2016). The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis. European Journal of Organic Chemistry, 2016(11), 2000-2012. https://doi.org/10.1002/ejoc.201600222A continuous flow process delivering key building blocks for a series of BCP modulator libraries is reported. A dynamically mixed flow reactor emerged as a pivotal technology in both synthesis and isolation phases enabling the processing of slurries... Read More about The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis.
Development of the industrial synthesis of vitamin A (2016)
Journal Article
Parker, G., Smith, L., & Baxendale, I. (2016). Development of the industrial synthesis of vitamin A. Tetrahedron, 72(13), 1645-1652. https://doi.org/10.1016/j.tet.2016.02.029The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the f... Read More about Development of the industrial synthesis of vitamin A.