Development of the industrial synthesis of vitamin A

Parker, G.L.; Smith, L.K.; Baxendale, I.R.

Abstract

The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first route in 1946, and critical contributions have been made by a number of scientists since, benefitting from fruitful collaborations between industry and academia. However, these improvements have been mostly incremental, and the work has been performed by a limited number of companies; as yet, there is still no ‘ideal’ synthesis of vitamin A.

Citation

Parker, G., Smith, L., & Baxendale, I. (2016). Development of the industrial synthesis of vitamin A. Tetrahedron, 72(13), 1645-1652. https://doi.org/10.1016/j.tet.2016.02.029

• Journal Article Type: Article
• Acceptance Date: Feb 10, 2016
• Online Publication Date: Feb 11, 2016
• Publication Date: 2016-03
• Deposit Date: Mar 22, 2016
• Journal: Tetrahedron
• Print ISSN: 0040-4020
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 72
• Issue: 13
• Pages: 1645-1652
• DOI: https://doi.org/10.1016/j.tet.2016.02.029
• Public URL: https://durham-repository.worktribe.com/output/1385818