Katherine Deck katherine.deck@durham.ac.uk
PGR Student Doctor of Philosophy
Synthesis of metal-binding amino acids
Deck, Katherine E. V.; Brittain, William D. G.
Authors
Dr Will Brittain william.d.brittain@durham.ac.uk
Associate Professor
Abstract
The ability for amino acid residues to bind metals underpins the functions of metalloproteins to conduct a plethora of critical processes in living organisms as well as unnatural applications in the fields of catalysis, sensing and medicinal chemistry. The capability to access metal-binding peptides heavily relies on the ability to generate appropriate building blocks. This review outlines recently developed strategies for the synthesis of metal binding non-proteinogenic amino acids. The chemistries to access, as well as to incorporate these amino acids into peptides is presented herein.
Citation
Deck, K. E. V., & Brittain, W. D. G. (online). Synthesis of metal-binding amino acids. Organic and Biomolecular Chemistry, https://doi.org/10.1039/d4ob01326c
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 28, 2024 |
Online Publication Date | Sep 30, 2024 |
Deposit Date | Oct 11, 2024 |
Publicly Available Date | Oct 11, 2024 |
Journal | Organic & Biomolecular Chemistry |
Print ISSN | 1477-0520 |
Electronic ISSN | 1477-0539 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1039/d4ob01326c |
Public URL | https://durham-repository.worktribe.com/output/2948189 |
Files
Published Journal Article (Advance Online Version)
(4.6 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/3.0/
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