Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(i) complexes

Zhao, Yiming; Meloni, Fernanda; Male, Louise; Le Duff, Cécile S.; Brittain, William D. G.; Buckley, Benjamin R.; Fossey, John S.

Abstract

The synthesis of atropisomeric phoshino-triazoles is disclosed. It was found that the introduction of a phosphine functionality onto the 5-position of a 1,2,3-triazole ring could be highly restrictive towards the rotation around a triazole-aryl bond. VT NMR and chiral HPLC studies demonstrated that rotation was restricted even at high temperatures. Gold(I) chloride complexes of single-enantiomer phosphines were prepared and again demonstrated to be conformationally stable.

Citation

Zhao, Y., Meloni, F., Male, L., Le Duff, C. S., Brittain, W. D. G., Buckley, B. R., & Fossey, J. S. (2023). Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(i) complexes. Organic Chemistry Frontiers, 10(14), 3460-3466. https://doi.org/10.1039/d3qo00322a

• Journal Article Type: Article
• Acceptance Date: Apr 17, 2023
• Online Publication Date: Apr 18, 2023
• Publication Date: Apr 18, 2023
• Deposit Date: Aug 11, 2023
• Publicly Available Date: Aug 11, 2023
• Journal: Organic Chemistry Frontiers
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 14
• Pages: 3460-3466
• DOI: https://doi.org/10.1039/d3qo00322a
• Keywords: Organic Chemistry
• Public URL: https://durham-repository.worktribe.com/output/1715829