Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study

Zhang, Lai; Bounds, Alistair; Girkin, John

Abstract

Surgical wound infection is a global postoperative issue adding a significant clinical burden and increasing healthcare costs. Early detection and subsequent diagnosis of infection is vital for accurate, early, and effective treatments. In this paper, we report a pilot study exploring spatial frequency domain imaging (SFDI) to monitor, in-vivo, a biopsy wound in human skin. The reduced scattering coefficient, μ′s, absorption coefficient, μa and the oxygen saturation, StO2, were measured using a SFDI system at 617 and 850 nm. We found the μ's was better capable of monitoring structural changes, possible pus within the wound, re-epithelialization, and collagen fiber remodeling, than with the eye alone. The μa map is capable of revealing the total hemoglobin distribution in the wound area but was limited in some regions due to the scab covering. This case study indicates SFDI’s potential for monitoring and quantifying the process of surgical wound healing and infection.

Citation

Zhang, L., Bounds, A., & Girkin, J. (2024). Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study. Biomedical Optics Express, 15(10), 5872-5885. https://doi.org/10.1364/BOE.536843

• Journal Article Type: Article
• Acceptance Date: Sep 7, 2024
• Online Publication Date: Sep 13, 2024
• Publication Date: Oct 1, 2024
• Deposit Date: Sep 17, 2024
• Publicly Available Date: Sep 18, 2024
• Journal: Biomedical Optics Express
• Electronic ISSN: 2156-7085
• Publisher: Optica
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 10
• Pages: 5872-5885
• DOI: https://doi.org/10.1364/BOE.536843
• Public URL: https://durham-repository.worktribe.com/output/2866661