Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring

Zhang, Lai; Bounds, Alistair; Girkin, John

Abstract

Postoperative surgical wound infection is a serious problem around the globe, including in countries with advanced healthcare systems, and a method for early detection of infection is urgently required. We explore spatial frequency domain imaging (SFDI) for distinguishing changes in surgical wound healing based on the tissue scattering properties and surgical wound width measurements. A comprehensive numerical method is developed by applying a three-dimensional Monte Carlo simulation to a vertical heterogeneous wound model. The Monte Carlo simulation results are validated using resin phantom imaging experiments. We report on the SFDI lateral resolution with varying reduced scattering value and wound width and discuss the partial volume effect at the sharp vertical boundaries present in a surgical incision. The detection sensitivity of this method is dependent on spatial frequency, wound reduced scattering coefficient, and wound width. We provide guidelines for future SFDI instrument design and explanation for the expected error in SFDI measurements.

Citation

Zhang, L., Bounds, A., & Girkin, J. (2023). Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring. Journal of Biomedical Optics, 28(12), Article 126003. https://doi.org/10.1117/1.jbo.28.12.126003

• Journal Article Type: Article
• Acceptance Date: Nov 30, 2023
• Online Publication Date: Dec 14, 2023
• Publication Date: 2023-12
• Deposit Date: Dec 15, 2023
• Publicly Available Date: Dec 18, 2023
• Journal: Journal of Biomedical Optics
• Print ISSN: 1083-3668
• Publisher: Society of Photo-optical Instrumentation Engineers
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 12
• Article Number: 126003
• DOI: https://doi.org/10.1117/1.jbo.28.12.126003
• Keywords: Biomedical Engineering; Atomic and Molecular Physics, and Optics; Biomaterials; Electronic, Optical and Magnetic Materials
• Public URL: https://durham-repository.worktribe.com/output/2027444