Polyhalogenated heterocyclic compounds Part 45. Reactions of perfluoro-(4-isopropylpyridine) with oxygen, nitrogen and carbon nucleophiles

Chambers, R.D.; Hassan, M.A.; Hoskin, P.R.; Kenwright, A.; Richmond, P.; Sandford, G.

Abstract

Reactions between perfluoro-(4-isopropylpyridine) (1) and a variety of oxygen-, nitrogen- and carbon-centred nucleophiles are reported. A range of mono-, di- and tri-substituted perfluoro-(4-isopropylpyridine) derivatives were synthesised for which yields and regiochemistry depended on reaction conditions. The barriers to rotation for the perfluoro- isopropyl group in several pyridine systems were measured by F- 19 NMR spin-saturation transfer experiments. (C) 2001 Elsevier Science B.V. All rights reserved.

Citation

Chambers, R., Hassan, M., Hoskin, P., Kenwright, A., Richmond, P., & Sandford, G. (2001). Polyhalogenated heterocyclic compounds Part 45. Reactions of perfluoro-(4-isopropylpyridine) with oxygen, nitrogen and carbon nucleophiles. Journal of Fluorine Chemistry, 111(2), 135-146

• Journal Article Type: Article
• Publication Date: 2001-10
• Journal: Journal of Fluorine Chemistry
• Print ISSN: 0022-1139
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 111
• Issue: 2
• Pages: 135-146
• Publisher URL: <Go to ISI>://000171759900005