Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR

Aguilar, Juan A.; Belda, Raquel; Gaunt, Benjamin R.; Kenwright, Alan M.; Kuprov, Ilya

Abstract

Recent developments in data sampling and processing techniques have made it possible to acquire 2‐dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of 2‐dimensional techniques including TOCSY and HSQC. In this paper, we investigate some of the problems in applying such techniques to COSY spectra and suggest a modification to the classic experiment that alleviates some of these problems.

Citation

Aguilar, J. A., Belda, R., Gaunt, B. R., Kenwright, A. M., & Kuprov, I. (2018). Separating the coherence transfer from chemical shift evolution in high-resolution pure shift COSY NMR. Magnetic Resonance in Chemistry, 56(10), 969-975. https://doi.org/10.1002/mrc.4727

• Journal Article Type: Article
• Acceptance Date: Feb 15, 2018
• Online Publication Date: Apr 11, 2018
• Publication Date: Oct 1, 2018
• Deposit Date: Jul 30, 2018
• Publicly Available Date: Apr 11, 2019
• Journal: Magnetic Resonance in Chemistry
• Print ISSN: 0749-1581
• Electronic ISSN: 1097-458X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 10
• Pages: 969-975
• DOI: https://doi.org/10.1002/mrc.4727
• Public URL: https://durham-repository.worktribe.com/output/1320145
• Related Public URLs: https://eprints.soton.ac.uk/419031/