Rewriteable DNA Microarrays

Schofield, W.C.E.; McGettrick, J.; Bradley, T.J.; Badyal, J.P.S.; Przyborski, S.A.

Abstract

Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.

Citation

Schofield, W., McGettrick, J., Bradley, T., Badyal, J., & Przyborski, S. (2006). Rewriteable DNA Microarrays. Journal of the American Chemical Society, 128(7), 2280–2285. https://doi.org/10.1021/ja056367r

• Journal Article Type: Article
• Online Publication Date: Jan 28, 2006
• Publication Date: Feb 1, 2006
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Publisher: American Chemical Society
• Volume: 128
• Issue: 7
• Pages: 2280–2285
• DOI: https://doi.org/10.1021/ja056367r
• Public URL: https://durham-repository.worktribe.com/output/1554951