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Rewriteable DNA Microarrays

Schofield, W.C.E.; McGettrick, J.; Bradley, T.J.; Badyal, J.P.S.; Przyborski, S.A.


W.C.E. Schofield

J. McGettrick

T.J. Bradley


Thiol-terminated single-stranded deoxyribonucleic acids (ssDNA) can be immobilized onto pulsed plasma deposited poly(allylmercaptan) surfaces via disulfide bridge chemistry and are found to readily undergo nucleic acid hybridization. Unlike other methods for oligonucleotide attachment to solid surfaces, this approach is shown to be independent of substrate material or geometry, and amenable to highly efficient rewriting.


Schofield, W., McGettrick, J., Bradley, T., Badyal, J., & Przyborski, S. (2006). Rewriteable DNA Microarrays. Journal of the American Chemical Society, 128(7), 2280–2285.

Journal Article Type Article
Online Publication Date Jan 28, 2006
Publication Date Feb 1, 2006
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Publisher American Chemical Society
Volume 128
Issue 7
Pages 2280–2285
Public URL