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DengueTools: Innovative tools and strategies for surveillance and control of dengue

Wilder-Smith, A.; Renhorn, K.-E.; Tissera, H.; Bakar, S.A.; Alphey, L.; Kittayapong, P.; Lindsay, S.W.; Logan, J.; Hatz, C.; Reiter, P.; Rocklöv, J.; Byass, P.; Louis, V.R.; Tozan, Y.; Massad, E.; Tenorio, A.; Lagneau, C.; L’Ambert, G.; Brooks, D.; Wegerdt, J.; Gubler, D.

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A. Wilder-Smith

K.-E. Renhorn

H. Tissera

S.A. Bakar

L. Alphey

P. Kittayapong

J. Logan

C. Hatz

P. Reiter

J. Rocklöv

P. Byass

V.R. Louis

Y. Tozan

E. Massad

A. Tenorio

C. Lagneau

G. L’Ambert

D. Brooks

J. Wegerdt

D. Gubler


Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infectionsworldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world’s population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of ‘Comprehensive control of Dengue fever under changing climatic conditions’. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named ‘DengueTools’ to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe) in the context of globalization and climate change. The consortium comprises 12 work packages to address a set of research questions in three areas: Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring. Research area 2: Develop novel strategies to prevent dengue in children. Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change. In this paper, we report on the rationale and specific study objectives of ‘DengueTools’. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant Agreement Number: 282589 Dengue Tools.


Wilder-Smith, A., Renhorn, K., Tissera, H., Bakar, S., Alphey, L., Kittayapong, P., …Gubler, D. (2012). DengueTools: Innovative tools and strategies for surveillance and control of dengue. Global Health Action, 5, Article 17273.

Journal Article Type Article
Publication Date Mar 22, 2012
Deposit Date Jul 23, 2012
Publicly Available Date Jun 24, 2014
Journal Global Health Action
Print ISSN 1654-9716
Electronic ISSN 1654-9880
Publisher Taylor and Francis Group
Peer Reviewed Peer Reviewed
Volume 5
Article Number 17273
Keywords Dengue, Dengue control, Dengue diagnostics, Economic evaluation, Entomology, Climate change, Early warning systems, Risk mapping, Surveillance, Globalization.


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Copyright Statement
© 2012 Annelies Wilder-Smith et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (, permitting all non-commercial use, distribution, and<br /> reproduction in any medium, provided the original work is properly cited.

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