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Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups

Joubert, Fanny; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

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Authors

Fanny Joubert

Osama M. Musa

Neil R. Cameron



Abstract

Lactam groups were introduced onto the backbone of hydroxyethyl cellulose (HEC) to modify properties, such as solubility in organic solvents and solution viscosity and to introduce possible antibacterial activity. Functionalization was achieved using 1-(hydroxymethyl)-2-pyrrolidinone (HMP), and the functionalization reactions were investigated using NMR spectroscopy. The covalent attachment between HEC and HMP was confirmed using 1H-13C correlated NMR experiments. Degrees of functionalization were calculated using integrated 13C NMR spectra, with values of up to 0.9 being demonstrated on the primary alcohol functionality of HEC. The functionalized HECs showed markedly different properties to unfunctionalized HEC, including the ability to swell considerably in water. Functionalized HEC displayed increased thermal stability and reduced solution viscosity compared with unfunctionalized HEC. Moreover, functionalization altered the bacterial adhesion characteristics compared with unfunctionalized HEC.

Citation

Joubert, F., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups. Journal of Polymer Science Part A: Polymer Chemistry, 53(1), 68-78. https://doi.org/10.1002/pola.27441

Journal Article Type Article
Acceptance Date Oct 5, 2014
Online Publication Date Oct 29, 2014
Publication Date Jan 1, 2015
Deposit Date Dec 10, 2014
Publicly Available Date Jan 21, 2015
Journal Journal of Polymer Science Part A: Polymer Chemistry
Print ISSN 0887-624X
Electronic ISSN 1099-0518
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 53
Issue 1
Pages 68-78
DOI https://doi.org/10.1002/pola.27441
Keywords Biopolymers, Modification, Polysaccharides, Synthesis.

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Published Journal Article (926 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2014 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.






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