Nucleophilic Trifluoromethylation of Electron-Deficient Arenes

Pike, Jack A.; Walton, James William

Abstract

A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion of nitroarenes into 1,2-trifluoromethylated nitroarenes, via a C‒H activation pathway. Furthermore, a substitution of nitroarenes to trifluoromethyl arenes is also presented.

Citation

Pike, J. A., & Walton, J. W. (2017). Nucleophilic Trifluoromethylation of Electron-Deficient Arenes. Chemical Communications, 53(71), https://doi.org/10.1039/c7cc05415g

• Journal Article Type: Article
• Acceptance Date: Aug 14, 2017
• Online Publication Date: Aug 14, 2017
• Publication Date: Aug 14, 2017
• Deposit Date: Aug 16, 2017
• Publicly Available Date: Aug 14, 2018
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 53
• Issue: 71
• DOI: https://doi.org/10.1039/c7cc05415g
• Public URL: https://durham-repository.worktribe.com/output/1379030