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Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Mishra, Atreyee; Djoko, Karrera Y.; Lee, Yi-Hsuan; Lord, Rianne M.; Kaul, Grace; Akhir, Abdul; Saxena, Deepanshi; Chopra, Sidharth; Walton, James W.

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Authors

Atreyee Mishra

Karrera Y. Djoko

Yi-Hsuan Lee

Rianne M. Lord

Grace Kaul

Abdul Akhir

Deepanshi Saxena

Sidharth Chopra



Abstract

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

Citation

Mishra, A., Djoko, K. Y., Lee, Y., Lord, R. M., Kaul, G., Akhir, A., …Walton, J. W. (2023). Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic and Biomolecular Chemistry, 21(12), 2539-2544. https://doi.org/10.1039/d2ob01224c

Journal Article Type Article
Acceptance Date Dec 20, 2022
Online Publication Date Mar 1, 2023
Publication Date Mar 28, 2023
Deposit Date Mar 27, 2023
Publicly Available Date Mar 27, 2023
Journal Organic & Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 21
Issue 12
Pages 2539-2544
DOI https://doi.org/10.1039/d2ob01224c
Public URL https://durham-repository.worktribe.com/output/1177022

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