Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Mishra, Atreyee; Djoko, Karrera Y.; Lee, Yi-Hsuan; Lord, Rianne M.; Kaul, Grace; Akhir, Abdul; Saxena, Deepanshi; Chopra, Sidharth; Walton, James W.

Abstract

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

Citation

Mishra, A., Djoko, K. Y., Lee, Y.-H., Lord, R. M., Kaul, G., Akhir, A., Saxena, D., Chopra, S., & Walton, J. W. (2023). Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic and Biomolecular Chemistry, 21(12), 2539-2544. https://doi.org/10.1039/d2ob01224c

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2022
• Online Publication Date: Mar 1, 2023
• Publication Date: Mar 28, 2023
• Deposit Date: Mar 27, 2023
• Publicly Available Date: Mar 27, 2023
• Journal: Organic & Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 12
• Pages: 2539-2544
• DOI: https://doi.org/10.1039/d2ob01224c
• Public URL: https://durham-repository.worktribe.com/output/1177022