Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Mishra, Atreyee; Djoko, Karrera Y.; Lee, Yi-Hsuan; Lord, Rianne M.; Kaul, Grace; Akhir, Abdul; Saxena, Deepanshi; Chopra, Sidharth; Walton, James W.

Abstract

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

Citation

Mishra, A., Djoko, K. Y., Lee, Y., Lord, R. M., Kaul, G., Akhir, A., …Walton, J. W. (2023). Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic and Biomolecular Chemistry, 21(12), 2539-2544. https://doi.org/10.1039/d2ob01224c

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2022
• Online Publication Date: Mar 1, 2023
• Publication Date: Mar 28, 2023
• Deposit Date: Mar 27, 2023
• Publicly Available Date: Mar 27, 2023
• Journal: Organic & Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 12
• Pages: 2539-2544
• DOI: https://doi.org/10.1039/d2ob01224c