Flow Synthesis of Coumalic Acid and its Derivatization

Smith, Laura K.; Baxendale, Ian R.

Abstract

Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address with the aid of tubular flow systems and a simple heated rotating flow reactor. The prepared coumalate derivatives can be further used in inverse electron demand Diels-Alder reactions to synthesise compounds with many applications including molecular electronics, with the added advantage of providing metal-free preparations.

Citation

Smith, L. K., & Baxendale, I. R. (2018). Flow Synthesis of Coumalic Acid and its Derivatization. Reaction Chemistry and Engineering, 3(5), 722-732. https://doi.org/10.1039/c8re00116b

• Journal Article Type: Article
• Acceptance Date: Jul 18, 2018
• Online Publication Date: Jul 20, 2018
• Publication Date: Oct 1, 2018
• Deposit Date: Jul 23, 2018
• Publicly Available Date: Jul 18, 2019
• Journal: Reaction Chemistry and Engineering
• Electronic ISSN: 2058-9883
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 5
• Pages: 722-732
• DOI: https://doi.org/10.1039/c8re00116b
• Public URL: https://durham-repository.worktribe.com/output/1325519