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Flow Synthesis of Coumalic Acid and its Derivatization

Smith, Laura K.; Baxendale, Ian R.

Flow Synthesis of Coumalic Acid and its Derivatization Thumbnail


Laura K. Smith


Coumalic acid is a valuable platform compound which can be prepared from malic acid, a biorenewable feedstock readily derived from the fermentation of glucose. Current batch procedures to synthesise coumalic acid have several drawbacks, which we address with the aid of tubular flow systems and a simple heated rotating flow reactor. The prepared coumalate derivatives can be further used in inverse electron demand Diels-Alder reactions to synthesise compounds with many applications including molecular electronics, with the added advantage of providing metal-free preparations.


Smith, L. K., & Baxendale, I. R. (2018). Flow Synthesis of Coumalic Acid and its Derivatization. Reaction Chemistry and Engineering, 3(5), 722-732.

Journal Article Type Article
Acceptance Date Jul 18, 2018
Online Publication Date Jul 20, 2018
Publication Date Oct 1, 2018
Deposit Date Jul 23, 2018
Publicly Available Date Jul 18, 2019
Journal Reaction Chemistry and Engineering
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 3
Issue 5
Pages 722-732
Public URL


Accepted Journal Article (Supplementary information) (4.8 Mb)

Copyright Statement
Supplementary information

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