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The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled (2019)
Journal Article
Chan, M., Austen, J. M., Eacott, M. J., Easton, A., & Sanderson, D. J. (2019). The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled. Neurobiology of Learning and Memory, 161, 57-62. https://doi.org/10.1016/j.nlm.2019.03.006

NMDA receptor-dependent synaptic plasticity has been proposed to be important for encoding of memories. Consistent with this hypothesis, the non-competitive NMDA receptor antagonist, MK-801, has been found to impair performance on tests of memory. In... Read More about The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled.

Incidental context information increases recollection (2017)
Journal Article
Ameen-Ali, K., Norman, L., Eacott, M., & Easton, A. (2017). Incidental context information increases recollection. Learning & Memory, 24(3), 136-139. https://doi.org/10.1101/lm.042622.116

The current study describes a receiver-operating characteristic (ROC) task for human participants based on the spontaneous recognition memory paradigms typically used with rodents. Recollection was significantly higher when an object was in the same... Read More about Incidental context information increases recollection.

Moving beyond standard procedures to assess spontaneous recognition memory (2015)
Journal Article
Ameen-Ali, K., Easton, A., & Eacott, M. (2015). Moving beyond standard procedures to assess spontaneous recognition memory. Neuroscience & Biobehavioral Reviews, 53, 37-51. https://doi.org/10.1016/j.neubiorev.2015.03.013

This review will consider how spontaneous tasks have been applied alongside neuroscientific techniques to test complex forms of recognition memory for objects and their environmental features, e.g. the spatial location of an object or the context in... Read More about Moving beyond standard procedures to assess spontaneous recognition memory.

Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease (2013)
Journal Article
Davis, K., Easton, A., Eacott, M., & Gigg, J. (2013). Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease, 33(3), 681-698. https://doi.org/10.3233/jad-2012-121543

Episodic memory loss is a defining feature of early-stage Alzheimer’s disease (AD). A test of episodic-like memory for the rat, the What-Where-Which occasion task (WWWhich), requires the association of object, location, and contextual information to... Read More about Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease.

A new behavioural apparatus to reduce animal numbers in multiple types of spontaneous object recognition paradigms in rats (2012)
Journal Article
Ameen-Ali, K., Eacott, M., & Easton, A. (2012). A new behavioural apparatus to reduce animal numbers in multiple types of spontaneous object recognition paradigms in rats. Journal of Neuroscience Methods, 211(1), 66-76. https://doi.org/10.1016/j.jneumeth.2012.08.006

Standard object recognition procedures assess animals’ memory through their spontaneous exploration of novel objects or novel configurations of objects with other aspects of their environment. Such tasks are widely used in memory research, but also i... Read More about A new behavioural apparatus to reduce animal numbers in multiple types of spontaneous object recognition paradigms in rats.

The episodic nature of episodic-like memories (2012)
Journal Article
Easton, A., Webster, L., & Eacott, M. (2012). The episodic nature of episodic-like memories. Learning & Memory, 19(4), 146-150. https://doi.org/10.1101/lm.025676.112

Studying episodic memory in nonhuman animals has proved difficult because definitions in humans require conscious recollection. Here, we assessed humans’ experience of episodic-like recognition memory tasks that have been used with animals. It was fo... Read More about The episodic nature of episodic-like memories.

A specific role for septohippocampal acetylcholine in memory? (2012)
Journal Article
Easton, A., Douchamps, V., Eacott, M., & Lever, C. (2012). A specific role for septohippocampal acetylcholine in memory?. Neuropsychologia, 50(13), 3156-3168. https://doi.org/10.1016/j.neuropsychologia.2012.07.022

Acetylcholine has long been implicated in memory, including hippocampal-dependent memory, but the specific role for this neurotransmitter is difficult to identify in human neuropsychology. Here, we review the evidence for a mechanistic model of acety... Read More about A specific role for septohippocampal acetylcholine in memory?.

Cholinergic mechanisms of episodic memory: what specific behavioural tasks can tell us about specific neural mechanisms. (2011)
Journal Article
Easton, A., & Eacott, M. (2013). Cholinergic mechanisms of episodic memory: what specific behavioural tasks can tell us about specific neural mechanisms. Brain Research Bulletin, 92, 21-28. https://doi.org/10.1016/j.brainresbull.2011.09.008

Understanding the neural basis of episodic memory is crucial for understanding how to treat memory loss in normal ageing as well as in disorders such as Alzheimer's disease. However, it is only recently that episodic memory has been able to be reliab... Read More about Cholinergic mechanisms of episodic memory: what specific behavioural tasks can tell us about specific neural mechanisms..

Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory (2011)
Journal Article
Easton, A., Fitchett, A., Eacott, M., & Baxter, M. (2011). Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory. Hippocampus, 21(9), 1021-1027. https://doi.org/10.1002/hipo.20814

Loss of cholinergic cortical input is associated with diseases in which episodic memory impairment is a prominent feature, but the degree to which this neurochemical lesion can account for memory impairment in humans with neurodegenerative diseases r... Read More about Medial septal cholinergic neurons are necessary for context-place memory but not episodic-like memory.

Recollection is impaired, but familiarity remains intact in rats with lesions of the fornix (2009)
Journal Article
Easton, A., Zinkivskay, A., & Eacott, M. (2009). Recollection is impaired, but familiarity remains intact in rats with lesions of the fornix. Hippocampus, 19(9), 837-843. https://doi.org/10.1002/hipo.20567

It has been argued that a neural system including the hippocampus, fornix, mamillary bodies, and anterior thalamus is specifically involved in recollection, but not in familiarity based memory processes. Here we test this hypothesis using a task of e... Read More about Recollection is impaired, but familiarity remains intact in rats with lesions of the fornix.

Recollection in an episodic-like memory task in the rat (2005)
Journal Article
Eacott, M., Easton, A., & Zinkivskay, A. (2005). Recollection in an episodic-like memory task in the rat. Learning & Memory, 12(3), 221-223. https://doi.org/10.1101/lm.92505

Episodic memory in humans is the conscious recollection of a past event. Animal models of episodic-like memory assess the memory for "what" happened, "where" it happened, and either "when" it happened, or in "which" context it happened, although reco... Read More about Recollection in an episodic-like memory task in the rat.