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Outputs (16)

Space in the brain: how the hippocampal formation supports spatial cognition (2013)
Journal Article
Hartley, T., Lever, C., Burgess, N., & O'Keefe, J. (2014). Space in the brain: how the hippocampal formation supports spatial cognition. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1635), Article 20120510. https://doi.org/10.1098/rstb.2012.0510

Over the past four decades, research has revealed that cells in the hippocampal formation provide an exquisitely detailed representation of an animal's current location and heading. These findings have provided the foundations for a growing understan... Read More about Space in the brain: how the hippocampal formation supports spatial cognition.

How environment geometry affects grid cell symmetry and what we can learn from it (2013)
Journal Article
Krupic, J., Bauza, M., Burton, S., Lever, C., & O'Keefe, J. (2014). How environment geometry affects grid cell symmetry and what we can learn from it. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1635), Article 20130188. https://doi.org/10.1098/rstb.2013.0188

The mammalian hippocampal formation provides neuronal representations of environmental location but the underlying mechanisms are unclear. The majority of cells in medial entorhinal cortex and parasubiculum show spatially periodic firing patterns. Gr... Read More about How environment geometry affects grid cell symmetry and what we can learn from it.

Shape shifting: Local landmarks interfere with navigation by, and recognition of, global shape (2013)
Journal Article
Buckley, M., Smith, A., & Haselgrove, M. (2014). Shape shifting: Local landmarks interfere with navigation by, and recognition of, global shape. Journal of Experimental Psychology: Learning, Memory, and Cognition, 40(2), 492-510. https://doi.org/10.1037/a0034901

An influential theory of spatial navigation states that the boundary shape of an environment is preferentially encoded over and above other spatial cues, such that it is impervious to interference from alternative sources of information. We explored... Read More about Shape shifting: Local landmarks interfere with navigation by, and recognition of, global shape.

The role of nitric oxide in pre-synaptic plasticity and homeostasis (2013)
Journal Article
Hardingham, N., Dachtler, J., & Fox, K. (2013). The role of nitric oxide in pre-synaptic plasticity and homeostasis. Frontiers in Cellular Neuroscience, 7, Article 190. https://doi.org/10.3389/fncel.2013.00190

Since the observation that nitric oxide (NO) can act as an intercellular messenger in the brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre-synaptically at both glutamatergic and GABAergic synapses to alter... Read More about The role of nitric oxide in pre-synaptic plasticity and homeostasis.

Retinal Structure and Function in Achromatopsia : Implications for Gene Therapy (2013)
Journal Article
Sundaram, V., Wilde, C., Aboshiha, J., Cowing, J., Han, C., Langlo, C., …Michaelides, M. (2014). Retinal Structure and Function in Achromatopsia : Implications for Gene Therapy. Ophthalmology, 121(1), 234-245. https://doi.org/10.1016/j.ophtha.2013.08.017

Purpose: To characterize retinal structure and function in achromatopsia (ACHM) in preparation for clinical trials of gene therapy. Design: Cross-sectional study. Participants: Forty subjects with ACHM. Methods: All subjects underwent spectral domain... Read More about Retinal Structure and Function in Achromatopsia : Implications for Gene Therapy.

Multisensory Uncertainty Reduction for Hand Localization in Children and Adults (2013)
Journal Article
Nardini, M., Begus, K., & Mareschal, D. (2013). Multisensory Uncertainty Reduction for Hand Localization in Children and Adults. Journal of Experimental Psychology: Human Perception and Performance, 39(3), 773-787. https://doi.org/10.1037/a0030719

Adults can integrate multiple sensory estimates to reduce their uncertainty in perceptual and motor tasks. In recent studies, children did not show this ability until after 8 years. Here we investigated development of the ability to integrate vision... Read More about Multisensory Uncertainty Reduction for Hand Localization in Children and Adults.

Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats (2013)
Journal Article
Wells, C., Amos, D., Jeewajee, A., Douchamps, V., Rodgers, R., O’Keefe, J., …Lever, C. (2013). Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats. Journal of Neuroscience, 33(20), 8650-8667. https://doi.org/10.1523/jneurosci.5040-12.2013

Hippocampal processing is strongly implicated in both spatial cognition and anxiety and is temporally organized by the theta rhythm. However, there has been little attempt to understand how each type of processing relates to the other in behaving ani... Read More about Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats.

Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine (2013)
Journal Article
Douchamps, V., Jeewajee, A., Blundell, P., Burgess, N., & Lever, C. (2013). Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine. Journal of Neuroscience, 33(20), 8689-8704. https://doi.org/10.1523/jneurosci.4483-12.2013

The formation of new memories requires new information to be encoded in the face of proactive interference from the past. Two solutions have been proposed for hippocampal region CA1: (1) acetylcholine, released in novelty, selectively suppresses exci... Read More about Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine.

Within-compound associations explain potentiation and failure to overshadow learning based on geometry by discrete landmarks (2013)
Journal Article
Austen, J., Kosaki, Y., & McGregor, A. (2013). Within-compound associations explain potentiation and failure to overshadow learning based on geometry by discrete landmarks. Journal of experimental psychology. Animal behavior processes, 39(3), 259-272. https://doi.org/10.1037/a0032525

In three experiments, rats were trained to locate a submerged platform in one of the base corners of a triangular arena above each of which was suspended one of two distinctive landmarks. In Experiment 1, it was established that these landmarks diffe... Read More about Within-compound associations explain potentiation and failure to overshadow learning based on geometry by discrete landmarks.

Overshadowing of geometry learning by discrete landmarks in the water maze: Effects of relative salience and relative validity of competing cues (2013)
Journal Article
Kosaki, Y., Austen, J., & McGregor, A. (2013). Overshadowing of geometry learning by discrete landmarks in the water maze: Effects of relative salience and relative validity of competing cues. Journal of experimental psychology. Animal behavior processes, 39(2), 126-139. https://doi.org/10.1037/a0031199

The effects of stimulus salience and cue validity in the overshadowing of geometric features of an enclosed arena by discrete landmarks were investigated in rats using the water maze paradigm. Experiment 1 established that in a rhomboid-shaped arena,... Read More about Overshadowing of geometry learning by discrete landmarks in the water maze: Effects of relative salience and relative validity of competing cues.

Transfer of spatial search between environments in human adults and young children (Homo sapiens): implications for representation of local geometry by spatial systems (2013)
Journal Article
Lew, A., Usherwood, B., Fragkioudaki, F., Koukoumi, V., Smith, S., Austen, J., & McGregor, A. (2014). Transfer of spatial search between environments in human adults and young children (Homo sapiens): implications for representation of local geometry by spatial systems. Developmental Psychobiology, 56(3), 421-434. https://doi.org/10.1002/dev.21109

Whether animals represent environmental geometry in a global and/or local way has been the subject of recent debate. We applied a transfer of search paradigm between rectangular- and kite-shaped arenas to examine the performance of human adults (usin... Read More about Transfer of spatial search between environments in human adults and young children (Homo sapiens): implications for representation of local geometry by spatial systems.

Emotional prosody modulates attention in schizophrenia patients with hallucinations (2013)
Journal Article
Alba-Ferrara, L., de Erausquin, G., Hirnstein, M., Weis, S., & Hausmann, M. (2013). Emotional prosody modulates attention in schizophrenia patients with hallucinations. Frontiers in Human Neuroscience, 7, Article 59. https://doi.org/10.3389/fnhum.2013.00059

Recent findings have demonstrated that emotional prosody (EP) attracts attention involuntarily (Grandjean et al., 2008). The automat shift of attention toward emotionally salient stimuli can be overcome by attentional control (Hahn et al., 2010). Att... Read More about Emotional prosody modulates attention in schizophrenia patients with hallucinations.

Clever crows or unbalanced birds? (2013)
Journal Article
Dymond, S., Haselgrove, M., & McGregor, A. (2013). Clever crows or unbalanced birds?. Proceedings of the National Academy of Sciences, 110(5), Article E336. https://doi.org/10.1073/pnas.1218931110

Taylor et al. claimed that New Caledonian crows are capable of reasoning about “hidden causal agents.” Their recorded increases in hide inspections and abandoned trials in the unknown causal agent (UCA) condition relative to the human causal agent (H... Read More about Clever crows or unbalanced birds?.

Spontaneous object recognition memory is maintained following transformation of global geometric properties (2013)
Journal Article
Poulter, S., Kosaki, Y., Easton, A., & McGregor, A. (2013). Spontaneous object recognition memory is maintained following transformation of global geometric properties. Journal of experimental psychology. Animal behavior processes, 39(1), 93-98. https://doi.org/10.1037/a0030698

Studies of spontaneous behavior to assess memory are widespread, but often the relationships of objects to contexts and spatial locations are poorly defined. We examined whether object-location memory was maintained following global, but not local, c... Read More about Spontaneous object recognition memory is maintained following transformation of global geometric properties.

Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease (2013)
Journal Article
Davis, K., Easton, A., Eacott, M., & Gigg, J. (2013). Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease, 33(3), 681-698. https://doi.org/10.3233/jad-2012-121543

Episodic memory loss is a defining feature of early-stage Alzheimer’s disease (AD). A test of episodic-like memory for the rat, the What-Where-Which occasion task (WWWhich), requires the association of object, location, and contextual information to... Read More about Episodic-Like Memory for What-Where-Which Occasion is Selectively Impaired in the 3xTgAD Mouse Model of Alzheimer’s Disease.