Dr Alessandro Borghi's Outputs (40)

Cone beam CT for the assessment of bone microstructure to predict head shape changes after spring-assisted craniosynostosis surgery. (2024)
Journal Article
Wolffenbuttel, T., Ajami, S., Borghi, A., Schievano, S., Dunaway, D., Jeelani, N. U. O., & Koudstaal, M. (2025). Cone beam CT for the assessment of bone microstructure to predict head shape changes after spring-assisted craniosynostosis surgery. Journal of Cranio-Maxillofacial Surgery, 128(49), 142-153. https://doi.org/10.1016/j.jcms.2024.11.014

Head shape changes following spring-cranioplasty for craniosynostosis (CS) can be difficult to predict. While previous research has indicated a connection between surgical outcomes and calvarial bone microstructure ex-vivo, there exists a demand for... Read More about Cone beam CT for the assessment of bone microstructure to predict head shape changes after spring-assisted craniosynostosis surgery..

Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis (2024)
Journal Article
Ajami, S., Van den Dam, Z., Hut, J., Savery, D., Chin, M., Koudstaal, M., Steacy, M., Carriero, A., Pitsillides, A., Chang, Y., Rau, C., Marathe, S., Dunaway, D., Jeelani, N. U. O., Schievano, S., Pauws, E., & Borghi, A. (2024). Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis. Journal of Anatomy, 245(6), 864-873. https://doi.org/10.1111/joa.14121

Crouzon syndrome is a congenital craniofacial disorder caused by mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2). It is characterized by the premature fusion of cranial sutures, leading to a brachycephalic head shape, and midfacial hypop... Read More about Cranial bone microarchitecture in a mouse model for syndromic craniosynostosis.

Surgical strategy in treatment of metopic synostosis in a single centre experience: technical note and quantitative analysis of the outcomes. (2024)
Journal Article
Zucchelli, M., Ruggiero, F., Babini, M., Lefosse, M., Borghi, A., Rodriguez-Florez, N., Tarsitano, A., Nicolini, F., & Galassi, E. (2024). Surgical strategy in treatment of metopic synostosis in a single centre experience: technical note and quantitative analysis of the outcomes. Child's Nervous System, 40, 3963-3970. https://doi.org/10.1007/s00381-024-06520-7

Trigonocephaly is the most common craniosynostosis involving orbits. Although some degree of agreement has been reached regarding surgical timing and indications for treatment, there is no consensus regarding the ideal operative technique to guarante... Read More about Surgical strategy in treatment of metopic synostosis in a single centre experience: technical note and quantitative analysis of the outcomes..

A computational modelling tool for prediction of head reshaping following endoscopic strip craniectomy and helmet therapy for the treatment of scaphocephaly (2024)
Journal Article
Deliege, L., Carriero, A., Ong, J., James, G., Jeelani, O., Dunaway, D., …Borghi, A. (2024). A computational modelling tool for prediction of head reshaping following endoscopic strip craniectomy and helmet therapy for the treatment of scaphocephaly. Computers in Biology and Medicine, 177, Article 108633. https://doi.org/10.1016/j.compbiomed.2024.108633

Endoscopic strip craniectomy followed by helmet therapy (ESCH) is a minimally invasive approach for correcting sagittal craniosynostosis. The treatment involves a patient-specific helmet designed to facilitate lateral growth while constraining sagitt... Read More about A computational modelling tool for prediction of head reshaping following endoscopic strip craniectomy and helmet therapy for the treatment of scaphocephaly.

Understanding the influence of surgical parameters on craniofacial surgery outcomes: a computational study (2024)
Journal Article
He, K. H., Bruse, J. L., Rodriguez-Florez, N., Dunaway, D., Jeelani, O., Schievano, S., & Borghi, A. (2024). Understanding the influence of surgical parameters on craniofacial surgery outcomes: a computational study. Royal Society Open Science, 11(4), Article 231158. https://doi.org/10.1098/rsos.231158

Sagittal craniosynostosis (SC) is a congenital condition whereby the newborn skull develops abnormally owing to the premature ossification of the sagittal suture. Spring-assisted cranioplasty (SAC) is a minimally invasive surgical technique to treat... Read More about Understanding the influence of surgical parameters on craniofacial surgery outcomes: a computational study.

In Vitro Assessment of the Neuro-Compatibility of Fe-20Mn as a Potential Bioresorbable Material for Craniofacial Surgery (2024)
Journal Article
Ajami, S., Kraaneveld, C., Koudstaal, M., Dunaway, D., Jeelani, N. U. O., Schievano, S., Bregoli, C., Fiocchi, J., Biffi, C. A., Tuissi, A., Borghi, A., Schievano, S., Kraaneveld, C., Koudstaal, M., & Tuissi, A. (2024). In Vitro Assessment of the Neuro-Compatibility of Fe-20Mn as a Potential Bioresorbable Material for Craniofacial Surgery. Medicina, 60(3), 440. https://doi.org/10.3390/medicina60030440

Background and Objectives: Spring-assisted surgery is a popular option for the treatment of non-syndromic craniosynostosis. The main drawback of this procedure is the need for a second surgery for spring removal, which could be avoided if a distracto... Read More about In Vitro Assessment of the Neuro-Compatibility of Fe-20Mn as a Potential Bioresorbable Material for Craniofacial Surgery.

What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis? (2024)
Journal Article
Elawadly, A. M., Smith, L. P. J., Borghi, A., Abdelaziz, K. I., Silva, A. H. D., Dunaway, D. J., Jeelani, N. U. O., Ong, J., Hayward, R. D., & James, G. (2024). What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis?. Journal of neurosurgery, 33(4), 374-381. https://doi.org/10.3171/2023.11.PEDS23227

Outcomes of surgical repair of trigonocephaly are well reported in the literature, but there is a paucity of information on the natural history of unoperated children. The authors evaluated a group of unoperated children with metopic synostosis to de... Read More about What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis?.

Towards a radiation free numerical modelling framework to predict spring assisted correction of scaphocephaly (2023)
Journal Article
Garate Andikoetxea, B., Ajami, S., Rodriguez-Florez, N., Jeelani, N. U. O., Dunaway, D., Schievano, S., & Borghi, A. (online). Towards a radiation free numerical modelling framework to predict spring assisted correction of scaphocephaly. Computer Methods in Biomechanics and Biomedical Engineering, https://doi.org/10.1080/10255842.2023.2294262

Sagittal Craniosynostosis (SC) is a congenital craniofacial malformation, involving premature sagittal suture ossification; spring-assisted cranioplasty (SAC) - insertion of metallic distractors for skull reshaping - is an established method for trea... Read More about Towards a radiation free numerical modelling framework to predict spring assisted correction of scaphocephaly.

Spring-assisted posterior vault expansion: a parametric study to improve the intracranial volume increase prediction (2023)
Journal Article
Deliège, L., Ramdat Misier, K., Silva, D., James, G., Ong, J., Dunaway, D., …Borghi, A. (2023). Spring-assisted posterior vault expansion: a parametric study to improve the intracranial volume increase prediction. Scientific Reports, 13(1), Article 21371. https://doi.org/10.1038/s41598-023-48143-z

Spring-assisted posterior vault expansion has been adopted at the London Great Ormond Street Hospital for Children to treat raised intracranial pressure in patients affected by syndromic craniosynostosis, a congenital calvarial anomaly causing the pr... Read More about Spring-assisted posterior vault expansion: a parametric study to improve the intracranial volume increase prediction.

Soft tissue prediction in orthognathic surgery: Improving accuracy by means of anatomical details (2023)
Journal Article
Ruggiero, F., Borghi, A., Bevini, M., Badiali, G., Lunari, O., Dunaway, D., & Marchetti, C. (2023). Soft tissue prediction in orthognathic surgery: Improving accuracy by means of anatomical details. PLoS ONE, 18(11), e0294640. https://doi.org/10.1371/journal.pone.0294640

Three-dimensional virtual simulation of orthognathic surgery is now a well-established method in maxillo-facial surgery. The commercial software packages are still burdened by a consistent imprecision on soft tissue predictions. In this study, the au... Read More about Soft tissue prediction in orthognathic surgery: Improving accuracy by means of anatomical details.

Does the mutation type affect the response to cranial vault expansion in children with apert syndrome? (2023)
Journal Article
Goodarzi, M. R., Breakey, W. F., van de Lande, L. S., Borghi, A., O'Hara, J., Ong, J., James, G., Hayward, R., Schievano, S., Dunaway, D. J., & Jeelani, N. O. (2023). Does the mutation type affect the response to cranial vault expansion in children with apert syndrome?. Journal of Craniofacial Surgery, 34(3), 910-913. https://doi.org/10.1097/SCS.0000000000009126

The accuracy of computer-assisted surgical planning in predicting soft tissue responses after Le Fort I osteotomy: Retrospective analysis (2023)
Journal Article
Senyürek, S. A., Ajami, S., Ruggiero, F., Van de Lande, L., Caron, C. J., Schievano, S., Dunaway, D. J., Padwa, B., Koudstaal, M. J., & Borghi, A. (2023). The accuracy of computer-assisted surgical planning in predicting soft tissue responses after Le Fort I osteotomy: Retrospective analysis. Journal of Craniofacial Surgery, 34(1), 131-138. https://doi.org/10.1097/SCS.0000000000008970

The esthetic perception of morphological severity in scaphocephalic patients is correlated with specific head geometrical features (2022)
Journal Article
Borghi, A., Heutinck, P., Rodriguez-Florez, N., Koudstaal, M., Ruggiero, F., Ajami, S., Schievano, S., Jeelani, N., & Dunaway, D. (2023). The esthetic perception of morphological severity in scaphocephalic patients is correlated with specific head geometrical features. The Cleft Palate Craniofacial Journal, 60(12), 1591-1599. https://doi.org/10.1177/10556656221111307

Correlation between head shape and volumetric changes following spring-assisted posterior vault expansion (2022)
Journal Article
Ramdat Misier, K. R., Breakey, R. W., van de Lande, L. S., Biffi, B., Knoops, P. G., Schievano, S., Caron, C. J., Dunaway, D. J., Koudstaal, M. J., Jeelani, N. O., & Borghi, A. (2022). Correlation between head shape and volumetric changes following spring-assisted posterior vault expansion. Journal of Cranio-Maxillofacial Surgery, 50(4), 343-352

Parametrizing the genioplasty: a biomechanical virtual study on soft tissue behavior (2022)
Journal Article
Ruggiero, F., Badiali, G., Bevini, M., Marchetti, C., Ong, J., Bolognesi, F., Schievano, S., Dunaway, D., Bianchi, A., & Borghi, A. (2022). Parametrizing the genioplasty: a biomechanical virtual study on soft tissue behavior. International Journal of Computer Assisted Radiology and Surgery, 17(1), 55-64

Mechanical and morphological properties of parietal bone in patients with sagittal craniosynostosis (2022)
Journal Article
Ajami, S., Rodriguez-Florez, N., Ong, J., Jeelani, N. U. O., Dunaway, D., James, G., Angullia, F., Budden, C., Bozkurt, S., Ibrahim, A., Ferretti, P., Schievano, S., & Borghi, A. (2022). Mechanical and morphological properties of parietal bone in patients with sagittal craniosynostosis. Journal of the Mechanical Behavior of Biomedical Materials, 125(104929),

Spring-assisted posterior vault expansion-a single-centre experience of 200 cases (2021)
Journal Article
Breakey, R. W. F., van de Lande, L. S., Sidpra, J., Knoops, P. M., Borghi, A., O'Hara, J., Ong, J., James, G., Hayward, R., Schievano, S., Dunaway, D. J., & Jeelani, N. U. O. (2021). Spring-assisted posterior vault expansion-a single-centre experience of 200 cases. Child's Nervous System, 37(10), 3189-3197

Validation of an in-silico modelling platform for outcome prediction in spring assisted posterior vault expansion (2021)
Journal Article
Deliège, L., Misier, K. R., Bozkurt, S., Breakey, W., James, G., Ong, J., Dunaway, D., Jeelani, N. O., Schievano, S., & Borghi, A. (2021). Validation of an in-silico modelling platform for outcome prediction in spring assisted posterior vault expansion. Clinical Biomechanics, 88(105424),

Statistical shape modelling for the analysis of head shape variations (2021)
Journal Article
Heutinck, P., Knoops, P., Florez, N. R., Biffi, B., Breakey, W., James, G., Koudstaal, M., Schievano, S., Dunaway, D., Jeelani, O., & Borghi, A. (2021). Statistical shape modelling for the analysis of head shape variations. Journal of Cranio-Maxillofacial Surgery, 49(6), 449-455

Three-dimensional environment and vascularization induce osteogenic maturation of human adipose-derived stem cells comparable to that of bone-derived progenitors (2020)
Journal Article
Ibrahim, A., Rodriguez-Florez, N., Gardner, O. F., Zucchelli, E., New, S. E., Borghi, A., Dunaway, D., Bulstrode, N. W., & Ferretti, P. (2020). Three-dimensional environment and vascularization induce osteogenic maturation of human adipose-derived stem cells comparable to that of bone-derived progenitors. Stem Cells Translational Medicine, 9(12), 1651-1666