What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis?

Elawadly, Ahmed M; Smith, Luke P J; Borghi, Alessandro; Abdelaziz, Khaled I; Silva, Adikarige Haritha Dulanka; Dunaway, David J; Jeelani, Noor Ul Owase; Ong, Juling; Hayward, Richard D; James, Greg

Abstract

Outcomes of surgical repair of trigonocephaly are well reported in the literature, but there is a paucity of information on the natural history of unoperated children. The authors evaluated a group of unoperated children with metopic synostosis to describe the natural change in head shape over time. A database was screened for scans of children with unoperated trigonocephaly (2010-2021). Multisuture cases and those with a metopic ridge were excluded. Three-dimensional surface scans (3D stereophotogrammetry/CT) were used for morphological analysis. Nine previously published parameters were used: frontal angle (FA30°), anteroposterior (AP) volume ratio (APVR), AP area ratio (APAR), AP width ratios 1 and 2 (APWR1 and APWR2), and 4 AP diagonal ratios (30° right APDR [rAPDR30], 30° left APDR [lAPDR30], 60° right APDR [rAPDR60], and 60° left APDR [lAPDR60]). Ninety-seven scans were identified from a cohort of 316 patients with a single metopic suture, in which the male-to-female ratio was 2.7:1. Ages at the time of the scan ranged from 9 days to 11 years and were stratified into 4 groups: group 1, < 6 months; group 2, 6-12 months; group 3, 1-3 years; and group 4, > 3 years. Significant improvements were detected in 5 parameters (APVR, APAR, APWR1, rAPDR30, and lAPDR30) over time, whereas no significant differences were found in FA30, APWR2, rAPDR60, and lAPDR60 between age groups. Forehead shape (surface area and volume), as well as narrowing and anterolateral contour at the frontal points, differed significantly over time without surgery. However, forehead angulation, narrowing, and anterolateral contour at temporal points did not show significant differences. This knowledge will aid in surgical and parental decision-making.

Citation

Elawadly, A. M., Smith, L. P. J., Borghi, A., Abdelaziz, K. I., Silva, A. H. D., Dunaway, D. J., Jeelani, N. U. O., Ong, J., Hayward, R. D., & James, G. (2024). What can a morphometric study of unoperated children teach us about the natural history of metopic synostosis?. Journal of neurosurgery, 33(4), 374-381. https://doi.org/10.3171/2023.11.PEDS23227

• Journal Article Type: Article
• Acceptance Date: Nov 21, 2023
• Online Publication Date: Jan 19, 2024
• Publication Date: 2024-04
• Deposit Date: Feb 7, 2024
• Publicly Available Date: Feb 7, 2024
• Journal: Journal of neurosurgery. Pediatrics
• Print ISSN: 0022-3085
• Electronic ISSN: 1933-0693
• Publisher: American Association of Neurological Surgeons
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 4
• Pages: 374-381
• DOI: https://doi.org/10.3171/2023.11.PEDS23227
• Keywords: craniofacial, 3D scans, synostosis, metopic, stereophotogrammetry, unoperated, natural history
• Public URL: https://durham-repository.worktribe.com/output/2192759