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Professor Ashraf Khir's Outputs (4)

Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans (2023)
Journal Article
Koch Esteves, N., Khir, A. W., & González‐Alonso, J. (2023). Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans. Experimental Physiology, 108(9), 1154-1171. https://doi.org/10.1113/ep091275

Heat and exercise therapies are recommended to improve vascular health across the lifespan. However, the haemodynamic effects of hyperthermia, exercise and their combination are inconsistent in young and elderly people. Here we investigated the acute... Read More about Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans.

The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study (2023)
Journal Article
Abdullateef, S., & Khir, A. W. (2023). The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study. Computer Methods and Programs in Biomedicine, 238, https://doi.org/10.1016/j.cmpb.2023.107598

Background and Objectives Reflections measured at the aortic root are of physiological and clinical interest and thought to be composed of the superimposed reflections arriving from the upper and lower parts of the circulatory system. However, the sp... Read More about The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study.

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet (2023)
Journal Article
Alastruey, J., Charlton, P. H., Bikia, V., Paliakaite, B., Hametner, B., Bruno, R. M., …Westerhof, B. E. (2023). Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. American Journal of Physiology - Heart and Circulatory Physiology, 325(1), H1-H29. https://doi.org/10.1152/ajpheart.00705.2022

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We rev... Read More about Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.

Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta (2023)
Journal Article
Giudici, A., Spronck, B., Wilkinson, I., & Khir, A. (2023). Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta. Journal of the Mechanical Behavior of Biomedical Materials, 141, https://doi.org/10.1016/j.jmbbm.2023.105752

The arterial wall's tri-layered macroscopic and layer-specific microscopic structure determine its mechanical properties, which vary at different arterial locations. Combining layer-specific mechanical data and tri-layered modelling, this study aimed... Read More about Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta.