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Professor Ashraf Khir's Outputs (58)

Temporary Pacing Simulator: A Training Tool for Clinicians (2025)
Journal Article
Cretu, I., Tindale, A., Abbod, M., Balachandran, W., Khir, A. W., & Meng, H. (2025). Temporary Pacing Simulator: A Training Tool for Clinicians. Applied Sciences, 15(2), Article 573. https://doi.org/10.3390/app15020573

Cardiovascular diseases (CVDs) are the leading global cause of death, impacting nations worldwide. Despite medical advancements, managing patients who require temporary pacing (TP) after cardiac surgery remains challenging. TP devices are essential f... Read More about Temporary Pacing Simulator: A Training Tool for Clinicians.

A cavalpulmonary assist device utilising impedance pumping enhanced by peristaltic effect (2024)
Journal Article
Burns-Cox, A., Gan, L., & Khir, A. (2024). A cavalpulmonary assist device utilising impedance pumping enhanced by peristaltic effect. The International Journal of Artificial Organs, 47(10), 765-773. https://doi.org/10.1177/03913988241268419

Background: Fontan procedure, the standard surgical palliation to treat children with single ventricular defects, causes systemic complications over years due to lack of pumping at cavopulmonary junction. A device developed specifically for cavopulmo... Read More about A cavalpulmonary assist device utilising impedance pumping enhanced by peristaltic effect.

Synthesis of Multimodal Cardiological Signals Using a Conditional Wasserstein Generative Adversarial Network (2024)
Journal Article
Cretu, I., Tindale, A., Balachandran, W., Abbod, M., William Khir, A., & Meng, H. (2024). Synthesis of Multimodal Cardiological Signals Using a Conditional Wasserstein Generative Adversarial Network. IEEE Access, 12, 133994-134007. https://doi.org/10.1109/access.2024.3449134

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Recent advancements in machine learning have significantly enhanced early detection and treatment strategies for CVDs. While electrocardiogram (ECG) signals are commonly use... Read More about Synthesis of Multimodal Cardiological Signals Using a Conditional Wasserstein Generative Adversarial Network.

Manufacturing an Artificial Arterial Tree Using 3D printing (2024)
Journal Article
Hacham, W. S., & Khir, A. W. (2024). Manufacturing an Artificial Arterial Tree Using 3D printing. Heliyon, 10(11), Article e31764. https://doi.org/10.1016/j.heliyon.2024.e31764

Models of the arterial network are useful in studying mechanical cardiac assist devices as well as complex pathological states that are difficult to investigate in-vivo otherwise. Earlier work of artificial arterial tree (AAT) have... Read More about Manufacturing an Artificial Arterial Tree Using 3D printing.

A comparison of different methods to maximise signal extraction when using central venous pressure to optimise atrioventricular delay after cardiac surgery. (2024)
Journal Article
Cretu, I., Tindale, A., Abbod, M., Balachandran, W., Khir, A. W., & Meng, H. (2024). A comparison of different methods to maximise signal extraction when using central venous pressure to optimise atrioventricular delay after cardiac surgery. International Journal of Cardiology, 51, Article 101382. https://doi.org/10.1016/j.ijcha.2024.101382

Our group has shown that central venous pressure (CVP) can optimise atrioventricular (AV) delay in temporary pacing (TP) after cardiac surgery. However, the signal-to-noise ratio (SNR) is influenced both by the methods used to mitigate the pressure e... Read More about A comparison of different methods to maximise signal extraction when using central venous pressure to optimise atrioventricular delay after cardiac surgery..

Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans (2023)
Journal Article
Koch Esteves, N., Khir, A. W., & González‐Alonso, J. (2023). Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans. Experimental Physiology, 108(9), 1154-1171. https://doi.org/10.1113/ep091275

Heat and exercise therapies are recommended to improve vascular health across the lifespan. However, the haemodynamic effects of hyperthermia, exercise and their combination are inconsistent in young and elderly people. Here we investigated the acute... Read More about Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans.

The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study (2023)
Journal Article
Abdullateef, S., & Khir, A. W. (2023). The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study. Computer Methods and Programs in Biomedicine, 238, https://doi.org/10.1016/j.cmpb.2023.107598

Background and Objectives Reflections measured at the aortic root are of physiological and clinical interest and thought to be composed of the superimposed reflections arriving from the upper and lower parts of the circulatory system. However, the sp... Read More about The contribution of upper and lower body arterial vessels to the aortic root reflections: A one-dimensional computational study.

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet (2023)
Journal Article
Alastruey, J., Charlton, P. H., Bikia, V., Paliakaite, B., Hametner, B., Bruno, R. M., …Westerhof, B. E. (2023). Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. American Journal of Physiology - Heart and Circulatory Physiology, 325(1), H1-H29. https://doi.org/10.1152/ajpheart.00705.2022

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We rev... Read More about Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.

Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta (2023)
Journal Article
Giudici, A., Spronck, B., Wilkinson, I., & Khir, A. (2023). Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta. Journal of the Mechanical Behavior of Biomedical Materials, 141, https://doi.org/10.1016/j.jmbbm.2023.105752

The arterial wall's tri-layered macroscopic and layer-specific microscopic structure determine its mechanical properties, which vary at different arterial locations. Combining layer-specific mechanical data and tri-layered modelling, this study aimed... Read More about Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta.

Subject-Specific Pressure Normalization of Local Pulse Wave Velocity: Separating Intrinsic From Acute Load-Dependent Stiffening in Hypertensive Patients (2022)
Journal Article
Giudici, A., Palombo, C., Kozakova, M., Morizzo, C., Cruickshank, J. K., & Khir, A. W. (2022). Subject-Specific Pressure Normalization of Local Pulse Wave Velocity: Separating Intrinsic From Acute Load-Dependent Stiffening in Hypertensive Patients. Frontiers in Physiology, 12, Article 783457. https://doi.org/10.3389/fphys.2021.783457

Time-course of the human thoracic aorta ageing process assessed using uniaxial mechanical testing and constitutive modelling (2022)
Journal Article
Giudici, A., Li, Y., Yasmin, Cleary, S., Connolly, K., McEniery, C., Wilkinson, I. B., & Khir, A. W. (2022). Time-course of the human thoracic aorta ageing process assessed using uniaxial mechanical testing and constitutive modelling. Journal of the Mechanical Behavior of Biomedical Materials, 134, Article 105339. https://doi.org/10.1016/j.jmbbm.2022.105339

Age-related remodelling of the arterial wall shifts the load bearing from the compliant elastin network to the stiffer collagen fibres. While this phenomenon has been widely investigated in animal models, human studies are lacking due to shortage of... Read More about Time-course of the human thoracic aorta ageing process assessed using uniaxial mechanical testing and constitutive modelling.

Study Protocol: The Heart and Brain Study (2021)
Journal Article
Suri, S., Bulte, D., Chiesa, S. T., Ebmeier, K. P., Jezzard, P., Rieger, S. W., Pitt, J. E., Griffanti, L., Okell, T. W., Craig, M., Chappell, M. A., Blockley, N. P., Kivimaki, M., Singh-Manoux, A., Khir, A. W., Hughes, A. D., Deanfield, J. E., Jensen, D. E., Green, S. F., Sigutova, V., …Mackay, C. E. (2021). Study Protocol: The Heart and Brain Study. Frontiers in Physiology, 12, Article 643725. https://doi.org/10.3389/fphys.2021.643725

Noninvasive carotid pressure-diameter loops to identify viscoelastic properties in ageing, hypertension and type 2 diabetes (2021)
Journal Article
Giudici, A., Palombo, C., Kozakova, M., Morizzo, C., Penno, G., Jamagidze, G., Della Latta, D., Chiappino, D., Cruickshank, J. K., & Khir, A. W. (2021). Noninvasive carotid pressure-diameter loops to identify viscoelastic properties in ageing, hypertension and type 2 diabetes. Journal of Hypertension, 39(11), 2307-2317. https://doi.org/10.1097/hjh.0000000000002918

Impact of tapering of arterial vessels on blood pressure, pulse wave velocity, and wave intensity analysis using one-dimensional computational model (2021)
Journal Article
Abdullateef, S., Mariscal-Harana, J., & Khir, A. W. (2021). Impact of tapering of arterial vessels on blood pressure, pulse wave velocity, and wave intensity analysis using one-dimensional computational model. International Journal for Numerical Methods in Biomedical Engineering, 37(11), Article e3312. https://doi.org/10.1002/cnm.3312