Dr Patricia Muller's Outputs (38)

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection (2024)
Journal Article
Centeno, D., Farsinejad, S., Kochetkova, E., Volpari, T., Gladych-Macioszek, A., Klupczynska-Gabryszak, A., Polotaye, T., Greenberg, M., Kung, D., Hyde, E., Alshehri, S., Pavlovic, T., Sullivan, W., Plewa, S., Vakifahmetoglu-Norberg, H., Monsma, F. J., Muller, P. A. J., Matysiak, J., Zaborowski, M. P., DiFeo, A., …Iwanicki, M. (2024). Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection. Nutrients, 16(12), Article 1816. https://doi.org/10.3390/nu16121816

Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovar... Read More about Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection.

GOF Mutant p53 in Cancers: A Therapeutic Challenge (2022)
Journal Article
Lobsang, D., & Muller, P. A. (2022). GOF Mutant p53 in Cancers: A Therapeutic Challenge. Cancers, 14(20), Article 5091. https://doi.org/10.3390/cancers14205091

TP53 is mutated in the majority of human cancers. Mutations can lead to loss of p53 expression or expression of mutant versions of the p53 protein. These mutant p53 proteins have oncogenic potential. They can inhibit any remaining WTp53 in a dominant... Read More about GOF Mutant p53 in Cancers: A Therapeutic Challenge.

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane (2021)
Journal Article
Phatak, V., von Grabowiecki, Y., Janus, J., Officer, L., Behan, C., Aschauer, L., Pinon, L., Mackay, H., Zanivan, S., Norman, J., Kelly, M., Le Quesne, J., & Muller, P. (2021). Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. Cell Death and Disease, 12(2), https://doi.org/10.1038/s41419-021-03497-y

iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms (2021)
Journal Article
Hall, C., von Grabowiecki, Y., Pearce, S., Dive, C., Bagley, S., & Muller, P. (2021). iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms. Cancer Cell International, 21(1), https://doi.org/10.1186/s12935-021-01918-8

Ultraviolet light-induced collagen degradation inhibits melanoma invasion (2021)
Journal Article
Budden, T., Gaudy-Marqueste, C., Porter, A., Kay, E., Gurung, S., Earnshaw, C., Roeck, K., Craig, S., Traves, V., Krutmann, J., Muller, P., Motta, L., Zanivan, S., Malliri, A., Furney, S., Nagore, E., & Virós, A. (2021). Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nature Communications, 12(1), https://doi.org/10.1038/s41467-021-22953-z

Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer (2021)
Journal Article
von Grabowiecki, Y., Phatak, V., Aschauer, L., & Muller, P. A. (2021). Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer. Frontiers in Oncology, 11, Article 804107. https://doi.org/10.3389/fonc.2021.804107

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression o... Read More about Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer.

Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer (2021)
Journal Article
Alhebshi, H., Tian, K., Patnaik, L., Taylor, R., Bezecny, P., Hall, C., Muller, P. A., Safari, N., Menendez Creamer, D. P., Demonacos, C., Mutti, L., Bittar, M. N., & Krstic-Demonacos, M. (2021). Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer. International Journal of Molecular Sciences, 22(24), Article 13198. https://doi.org/10.3390/ijms222413198

Mutations in the p53 tumor suppressor are found in over 50% of cancers. p53 function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated the posttranslationally modified p53, including p53 a... Read More about Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer.

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7 (2020)
Journal Article
O'Regan, L., Barone, G., Adib, R., Woo, C., Jeong, H., Richardson, E., Richards, M., Muller, P., Collis, S., Fennell, D., Choi, J., Bayliss, R., & Fry, A. (2020). EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. Journal of Cell Science, 133(9), https://doi.org/10.1242/jcs.241505

The diverse functions of mutant 53, its family members and isoforms in cancer (2019)
Journal Article
Hall, C., & Muller, P. (2019). The diverse functions of mutant 53, its family members and isoforms in cancer. International Journal of Molecular Sciences, 20(24), https://doi.org/10.3390/ijms20246188

Biological relevance of cell-in-cell in cancers (2019)
Journal Article
Mackay, H., & Muller, P. (2019). Biological relevance of cell-in-cell in cancers. Biochemical Society Transactions, 47(2), 725-732. https://doi.org/10.1042/bst20180618

Genomic instability in mutant p53 cancer cells upon entotic engulfment (2018)
Journal Article
Mackay, H., Moore, D., Hall, C., Birkbak, N., Jamal-Hanjani, M., Karim, S., Phatak, V., Piñon, L., Morton, J., Swanton, C., Le Quesne, J., & Muller, P. (2018). Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-05368-1

Erratum to: Genomic instability in mutant p53 cancer cells upon entotic engulfment (Nature Communications, (2018), 9, 1, (3070), 10.1038/s41467-018-05368-1) (2018)
Journal Article
Mackay, H., Moore, D., Hall, C., Birkbak, N., Jamal-Hanjani, M., Karim, S., Phatak, V., Piñon, L., Morton, J., Swanton, C., Le Quesne, J., & Muller, P. (2018). Erratum to: Genomic instability in mutant p53 cancer cells upon entotic engulfment (Nature Communications, (2018), 9, 1, (3070), 10.1038/s41467-018-05368-1). Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-06026-2

Effect of mutant p53 proteins on glycolysis and mitochondrial metabolism (2017)
Journal Article
Eriksson, M., Ambroise, G., Ouchida, A., Queiroz, A., Smith, D., Gimenez-Cassina, A., Iwanicki, M., Muller, P., Norberg, E., & Vakifahmetoglu-Norberg, H. (2017). Effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Molecular and Cellular Biology, 37(24), https://doi.org/10.1128/mcb.00328-17

The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration (2016)
Journal Article
Hall, A., Lu, W.-T., Godfrey, J., Antonov, A., Paicu, C., Moxon, S., Dalmay, T., Wilczynska, A., Muller, P., & Bushell, M. (2016). The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death and Disease, 7, https://doi.org/10.1038/cddis.2016.91

Novel targets and interaction partners of mutant p53 Gain-Of-Function (2016)
Journal Article
Aschauer, L., & Muller, P. (2016). Novel targets and interaction partners of mutant p53 Gain-Of-Function. Biochemical Society Transactions, 44(2), 460-466. https://doi.org/10.1042/bst20150261

Metal toxicity and the p53 protein: An intimate relationship (2015)
Journal Article
Phatak, V., & Muller, P. (2015). Metal toxicity and the p53 protein: An intimate relationship. https://doi.org/10.1039/c4tx00117f

Functional interplay between MDM2, p63/p73 and mutant p53 (2015)
Journal Article
Stindt, M., Muller, P., Ludwig, R., Kehrloesser, S., Dötsch, V., & Vousden, K. (2015). Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene, 34(33), 4300-4310. https://doi.org/10.1038/onc.2014.359

c-Met and other cell surface molecules: Interaction, activation and functional consequences (2015)
Journal Article
Viticchiè, G., & Muller, P. (2015). c-Met and other cell surface molecules: Interaction, activation and functional consequences. Biomedicines, 3(1), 46-70. https://doi.org/10.3390/biomedicines3010046

Functions of TAp63 and p53 in restraining the development of metastatic cancer (2014)
Journal Article
Tan, E., Morton, J., Timpson, P., Tucci, P., Melino, G., Flores, E., Sansom, O., Vousden, K., & Muller, P. (2014). Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene, 33(25), 3325-3333. https://doi.org/10.1038/onc.2013.287

Mutant p53 in cancer: New functions and therapeutic opportunities (2014)
Journal Article
Muller, P., & Vousden, K. (2014). Mutant p53 in cancer: New functions and therapeutic opportunities. Cancer Cell, 25(3), 304-317. https://doi.org/10.1016/j.ccr.2014.01.021