Outputs (37)

GOF Mutant p53 in Cancers: A Therapeutic Challenge (2022)
Journal Article
Lobsang, D., & Muller, P. A. (2022). GOF Mutant p53 in Cancers: A Therapeutic Challenge. Cancers, 14(20), Article 5091. https://doi.org/10.3390/cancers14205091

TP53 is mutated in the majority of human cancers. Mutations can lead to loss of p53 expression or expression of mutant versions of the p53 protein. These mutant p53 proteins have oncogenic potential. They can inhibit any remaining WTp53 in a dominant... Read More about GOF Mutant p53 in Cancers: A Therapeutic Challenge.

Ultraviolet light-induced collagen degradation inhibits melanoma invasion (2021)
Journal Article
Budden, T., Gaudy-Marqueste, C., Porter, A., Kay, E., Gurung, S., Earnshaw, C., …Virós, A. (2021). Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nature Communications, 12(1), https://doi.org/10.1038/s41467-021-22953-z

iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms (2021)
Journal Article
Hall, C., von Grabowiecki, Y., Pearce, S., Dive, C., Bagley, S., & Muller, P. (2021). iRFP (near-infrared fluorescent protein) imaging of subcutaneous and deep tissue tumours in mice highlights differences between imaging platforms. Cancer Cell International, 21(1), https://doi.org/10.1186/s12935-021-01918-8

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane (2021)
Journal Article
Phatak, V., von Grabowiecki, Y., Janus, J., Officer, L., Behan, C., Aschauer, L., …Muller, P. (2021). Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. Cell Death and Disease, 12(2), https://doi.org/10.1038/s41419-021-03497-y

Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer (2021)
Journal Article
von Grabowiecki, Y., Phatak, V., Aschauer, L., & Muller, P. A. (2021). Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer. Frontiers in Oncology, 11, Article 804107. https://doi.org/10.3389/fonc.2021.804107

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression o... Read More about Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer.

Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer (2021)
Journal Article
Alhebshi, H., Tian, K., Patnaik, L., Taylor, R., Bezecny, P., Hall, C., …Krstic-Demonacos, M. (2021). Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer. International Journal of Molecular Sciences, 22(24), Article 13198. https://doi.org/10.3390/ijms222413198

Mutations in the p53 tumor suppressor are found in over 50% of cancers. p53 function is controlled through posttranslational modifications and cofactor interactions. In this study, we investigated the posttranslationally modified p53, including p53 a... Read More about Evaluation of the role of p53 tumor suppressor post-translational modifications and TTC5 cofactor in lung cancer.

EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7 (2020)
Journal Article
O'Regan, L., Barone, G., Adib, R., Woo, C., Jeong, H., Richardson, E., …Fry, A. (2020). EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. Journal of Cell Science, 133(9), https://doi.org/10.1242/jcs.241505

The diverse functions of mutant 53, its family members and isoforms in cancer (2019)
Journal Article
Hall, C., & Muller, P. (2019). The diverse functions of mutant 53, its family members and isoforms in cancer. International Journal of Molecular Sciences, 20(24), https://doi.org/10.3390/ijms20246188

Biological relevance of cell-in-cell in cancers (2019)
Journal Article
Mackay, H., & Muller, P. (2019). Biological relevance of cell-in-cell in cancers. Biochemical Society Transactions, 47(2), 725-732. https://doi.org/10.1042/bst20180618

Genomic instability in mutant p53 cancer cells upon entotic engulfment (2018)
Journal Article
Mackay, H., Moore, D., Hall, C., Birkbak, N., Jamal-Hanjani, M., Karim, S., …Muller, P. (2018). Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-05368-1

Erratum to: Genomic instability in mutant p53 cancer cells upon entotic engulfment (Nature Communications, (2018), 9, 1, (3070), 10.1038/s41467-018-05368-1) (2018)
Journal Article
Mackay, H., Moore, D., Hall, C., Birkbak, N., Jamal-Hanjani, M., Karim, S., …Muller, P. (2018). Erratum to: Genomic instability in mutant p53 cancer cells upon entotic engulfment (Nature Communications, (2018), 9, 1, (3070), 10.1038/s41467-018-05368-1). Nature Communications, 9(1), https://doi.org/10.1038/s41467-018-06026-2

Effect of mutant p53 proteins on glycolysis and mitochondrial metabolism (2017)
Journal Article
Eriksson, M., Ambroise, G., Ouchida, A., Queiroz, A., Smith, D., Gimenez-Cassina, A., …Vakifahmetoglu-Norberg, H. (2017). Effect of mutant p53 proteins on glycolysis and mitochondrial metabolism. Molecular and Cellular Biology, 37(24), https://doi.org/10.1128/mcb.00328-17

The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration (2016)
Journal Article
Hall, A., Lu, W., Godfrey, J., Antonov, A., Paicu, C., Moxon, S., …Bushell, M. (2016). The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death and Disease, 7, https://doi.org/10.1038/cddis.2016.91

Novel targets and interaction partners of mutant p53 Gain-Of-Function (2016)
Journal Article
Aschauer, L., & Muller, P. (2016). Novel targets and interaction partners of mutant p53 Gain-Of-Function. Biochemical Society Transactions, 44(2), 460-466. https://doi.org/10.1042/bst20150261

Metal toxicity and the p53 protein: An intimate relationship (2015)
Journal Article
Phatak, V., & Muller, P. (2015). Metal toxicity and the p53 protein: An intimate relationship. https://doi.org/10.1039/c4tx00117f

Functional interplay between MDM2, p63/p73 and mutant p53 (2015)
Journal Article
Stindt, M., Muller, P., Ludwig, R., Kehrloesser, S., Dötsch, V., & Vousden, K. (2015). Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene, 34(33), 4300-4310. https://doi.org/10.1038/onc.2014.359

c-Met and other cell surface molecules: Interaction, activation and functional consequences (2015)
Journal Article
Viticchiè, G., & Muller, P. (2015). c-Met and other cell surface molecules: Interaction, activation and functional consequences. Biomedicines, 3(1), 46-70. https://doi.org/10.3390/biomedicines3010046

Functions of TAp63 and p53 in restraining the development of metastatic cancer (2014)
Journal Article
Tan, E., Morton, J., Timpson, P., Tucci, P., Melino, G., Flores, E., …Muller, P. (2014). Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene, 33(25), 3325-3333. https://doi.org/10.1038/onc.2013.287

Mutant p53 in cancer: New functions and therapeutic opportunities (2014)
Journal Article
Muller, P., & Vousden, K. (2014). Mutant p53 in cancer: New functions and therapeutic opportunities. Cancer Cell, 25(3), 304-317. https://doi.org/10.1016/j.ccr.2014.01.021

P53 mutations in cancer (2013)
Journal Article
Muller, P., & Vousden, K. (2013). P53 mutations in cancer. Nature Cell Biology, 15(1), 2-8. https://doi.org/10.1038/ncb2641

NCF2/p67phox: A novel player in the anti-apoptotic functions of p53 (2013)
Journal Article
Muller, P. (2013). NCF2/p67phox: A novel player in the anti-apoptotic functions of p53. Cell Cycle, 12(1), https://doi.org/10.4161/cc.23173

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion (2013)
Journal Article
Muller, P., Trinidad, A., Timpson, P., Morton, J., Zanivan, S., Van Den Berghe, P., …Vousden, K. (2013). Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene, 32(10), 1252-1265. https://doi.org/10.1038/onc.2012.148

Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity (2013)
Journal Article
Trinidad, A., Muller, P., Cuellar, J., Klejnot, M., Nobis, M., Valpuesta, J., & Vousden, K. (2013). Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity. Molecular Cell, 50(6), 805-817. https://doi.org/10.1016/j.molcel.2013.05.002

Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype (2013)
Journal Article
Muller, P., Trinidad, A., Caswell, P., Norman, J., & Vousden, K. (2014). Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. Journal of Biological Chemistry, 289(1), 122-132. https://doi.org/10.1074/jbc.m113.502138

The control and processing of microRNAs (miRs) is critical in the regulation of all cellular responses. Previous studies have suggested that a reduction in the expression of certain miRs, or an overall decrease in miR processing through the partial d... Read More about Mutant p53 regulates dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration (2012)
Journal Article
Rainero, E., Caswell, P., Muller, P., Grindlay, J., Mccaffrey, M., Zhang, Q., …Norman, J. (2012). Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. Journal of Cell Biology, 196(2), 277-295. https://doi.org/10.1083/jcb.201109112

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion (2012)
Journal Article
Coffill, C., Muller, P., Oh, H., Neo, S., Hogue, K., Cheok, C., …Gunaratne, J. (2012). Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Reports, 13(7), 638-644. https://doi.org/10.1038/embor.2012.74

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article
Tucci, P., Agostini, M., Grespi, F., Markert, E., Terrinoni, A., Vousden, K., …Melino, G. (2012). Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences, 109(38), 15312-15317. https://doi.org/10.1073/pnas.1110977109

p53 and its mutants in tumor cell migration and invasion (2011)
Journal Article
Muller, P., Vousden, K., & Norman, J. (2011). p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), 209-218. https://doi.org/10.1083/jcb.201009059

COMMD1 expression is controlled by critical residues that determine XIAP binding (2009)
Journal Article
Maine, G., Mao, X., Muller, P., Komarck, C., Klomp, L., & Burstein, E. (2009). COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochemical Journal, 417(2), 601-609. https://doi.org/10.1042/bj20080854

Nuclear-cytosolic transport of COMMD1 regulates NF-κB and HIF-1 activity (2009)
Journal Article
Muller, P., De Sluis, B., Groot, A., Verbeek, D., Vonk, W., Maine, G., …Klomp, L. (2009). Nuclear-cytosolic transport of COMMD1 regulates NF-κB and HIF-1 activity. Traffic, 10(5), 514-527. https://doi.org/10.1111/j.1600-0854.2009.00892.x

ATOX1: A novel copper-responsive transcription factor in mammals? (2009)
Journal Article
Muller, P., & Klomp, L. (2009). ATOX1: A novel copper-responsive transcription factor in mammals?. International Journal of Biochemistry and Cell Biology, 41(6), 1233-1236. https://doi.org/10.1016/j.biocel.2008.08.001

Mutant p53 Drives Invasion by Promoting Integrin Recycling (2009)
Journal Article
Muller, P., Caswell, P., Doyle, B., Iwanicki, M., Tan, E., Karim, S., …Vousden, K. (2009). Mutant p53 Drives Invasion by Promoting Integrin Recycling. Cell, 139(7), 1327-1341. https://doi.org/10.1016/j.cell.2009.11.026

Novel perspectives in mammalian copper metabolism through the use of genome-wide approaches (2008)
Journal Article
Muller, P., & Klomp, L. (2008). Novel perspectives in mammalian copper metabolism through the use of genome-wide approaches. https://doi.org/10.1093/ajcn/88.3.821s

Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes (2007)
Journal Article
Muller, P., Van Bakel, H., Van De Sluis, B., Holstege, F., Wijmenga, C., & Klomp, L. (2007). Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. JBIC Journal of Biological Inorganic Chemistry, 12(4), 495-507. https://doi.org/10.1007/s00775-006-0201-y

Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice (2007)
Journal Article
Van De Sluis, B., Muller, P., Duran, K., Chen, A., Groot, A., Klomp, L., …Wijmenga, C. (2007). Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Molecular and Cellular Biology, 27(11), 4142-4156. https://doi.org/10.1128/mcb.01932-06

Molecular pathogenesis of Wilson and Menkes disease: Correlation of mutations with molecular defects and disease phenotypes (2007)
Journal Article
De Bie, P., Muller, P., Wijmenga, C., & Klomp, L. (2007). Molecular pathogenesis of Wilson and Menkes disease: Correlation of mutations with molecular defects and disease phenotypes. Journal of Medical Genetics, 44(11), 673-688. https://doi.org/10.1136/jmg.2007.052746

Distinct Wilson's Disease Mutations in ATP7B Are Associated With Enhanced Binding to COMMD1 and Reduced Stability of ATP7B (2007)
Journal Article
de Bie, P., van de Sluis, B., Burstein, E., van de Berghe, P., Muller, P., Berger, R., …Klomp, L. (2007). Distinct Wilson's Disease Mutations in ATP7B Are Associated With Enhanced Binding to COMMD1 and Reduced Stability of ATP7B. Gastroenterology, 133(4), 1316-1326. https://doi.org/10.1053/j.gastro.2007.07.020