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Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer

von Grabowiecki, Yanncik; Phatak, Vinaya; Aschauer, Lydia; Muller, Patricia AJ

Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer Thumbnail


Authors

Yanncik von Grabowiecki

Vinaya Phatak

Lydia Aschauer



Abstract

Rab11-FIP1 is a Rab effector protein that is involved in endosomal recycling and trafficking of various molecules throughout the endocytic compartments of the cell. The consequence of this can be increased secretion or increased membrane expression of those molecules. In general, expression of Rab11-FIP1 coincides with more tumourigenic and metastatic cell behaviour. Rab11-FIP1 can work in concert with oncogenes such as mutant p53, but has also been speculated to be an oncogene in its own right. In this perspective, we will discuss and speculate upon our observations that mutant p53 promotes Rab11-FIP1 function to not only promote invasive behaviour, but also chemoresistance by regulating a multitude of different proteins.

Citation

von Grabowiecki, Y., Phatak, V., Aschauer, L., & Muller, P. A. (2021). Rab11-FIP1/RCP functions as a major signalling hub in the oncogenic roles of mutant p53 in cancer. Frontiers in Oncology, 11, Article 804107. https://doi.org/10.3389/fonc.2021.804107

Journal Article Type Article
Acceptance Date Dec 3, 2021
Online Publication Date Dec 21, 2021
Publication Date 2021
Deposit Date Dec 16, 2021
Publicly Available Date Jan 25, 2022
Journal Frontiers in Oncology
Electronic ISSN 2234-943X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 804107
DOI https://doi.org/10.3389/fonc.2021.804107
Public URL https://durham-repository.worktribe.com/output/1219432

Files

Published Journal Article (3 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright © 2021 von Grabowiecki, Phatak, Aschauer and Muller. This is an openaccess article distributed under the terms of the Creative Commons Attribution
License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) and the copyright owner(s) are credited and that the
original publication in this journal is cited, in accordance with accepted academic
practice. No use, distribution or reproduction is permitted which does not comply with
these terms.





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