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Dr James Walton's Outputs (3)

Aggregation-induced emission switch showing high contrast mehanofluorochromism and solvatofluorochromism: Specifically detects HSO3− in bioimaging studies (2023)
Journal Article
Das, S., Pratim Das, P., Walton, J. W., Kheng Quah, C., Ghoshal, K., & Bhattacharyya, M. (2023). Aggregation-induced emission switch showing high contrast mehanofluorochromism and solvatofluorochromism: Specifically detects HSO3− in bioimaging studies. Dyes and Pigments, 217, Article 111413. https://doi.org/10.1016/j.dyepig.2023.111413

In this work, a novel mechanoresponsive luminescent (MRL) and aggregation induced emission (AIE) switch, 2-(4-((9-butyl-9H-carbazol-3-yl)ethynyl)benzylidene)malononitrile (CABM) has been synthesized by a perfect blending of the carbazole-based triple... Read More about Aggregation-induced emission switch showing high contrast mehanofluorochromism and solvatofluorochromism: Specifically detects HSO3− in bioimaging studies.

Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity (2023)
Journal Article
Mishra, A., Djoko, K. Y., Lee, Y.-H., Lord, R. M., Kaul, G., Akhir, A., Saxena, D., Chopra, S., & Walton, J. W. (2023). Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic and Biomolecular Chemistry, 21(12), 2539-2544. https://doi.org/10.1039/d2ob01224c

Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione cop... Read More about Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity.

Biotinylated selenocyanates: Potent and selective cytostatic agents (2023)
Journal Article
Roldán-Peña, J. M., Puerta, A., Dinić, J., Jovanović Stojanov, S., González-Bakker, A., Hicke, F. J., Mishra, A., Piyasaengthong, A., Maya, I., Walton, J. W., Pešić, M., Padrón, J. M., Fernández-Bolaños, J. G., & López, Ó. (2023). Biotinylated selenocyanates: Potent and selective cytostatic agents. Bioorganic Chemistry, 133, Article 106410. https://doi.org/10.1016/j.bioorg.2023.106410

Most of the currently available cytotoxic agents for tackling cancer are devoid of selectivity, thus causing severe side-effects. This situation stimulated us to develop new antiproliferative agents with enhanced affinity towards tumour cells. We foc... Read More about Biotinylated selenocyanates: Potent and selective cytostatic agents.