Sangita Das
Aggregation-induced emission switch showing high contrast mehanofluorochromism and solvatofluorochromism: Specifically detects HSO3− in bioimaging studies
Das, Sangita; Pratim Das, Partha; Walton, James W.; Kheng Quah, Ching; Ghoshal, Kakali; Bhattacharyya, Maitree
Authors
Partha Pratim Das
Dr James Walton james.walton@durham.ac.uk
Associate Professor
Ching Kheng Quah
Kakali Ghoshal
Maitree Bhattacharyya
Abstract
In this work, a novel mechanoresponsive luminescent (MRL) and aggregation induced emission (AIE) switch, 2-(4-((9-butyl-9H-carbazol-3-yl)ethynyl)benzylidene)malononitrile (CABM) has been synthesized by a perfect blending of the carbazole-based triple bond and benzyl malononitrile conjugated derivative via the ‘sonogashira coupling reaction’. The optoelectronic properties of this donor–π–acceptor (D–π–A) framework spontaneously originates a prominent yellow fluorescence which further exhibits a mechanical stimuli induced orange – red emission. Interestingly, just after fumed with dichloromethane (DCM) vapor, the rubbed CABM powder facilely exhibits a restoration in the emission profile as well as fluorescence color. Moreover, this multidimensional switch, CABM shows a prominent solvent dependent sensitivity towards different polarities of organic solvents. CABM also exhibits a typical intramolecular charge transfer (ICT) mechanism along with AIE behaviors with high solid-state efficiency. Importantly, CABM acts as a fluorescence indicator for the qualitative and quantitative detection of low-level water content as impurity in organic solvent. CABM is also found to specifically sense HSO3− anion compared to other guest anions. These promising observations inspire us for the bioimaging studies by using human blood cells which clearly exhibit that CABM can be used to detect HSO3− in human peripheral blood mononuclear cells (PBMCs).
Citation
Das, S., Pratim Das, P., Walton, J. W., Kheng Quah, C., Ghoshal, K., & Bhattacharyya, M. (2023). Aggregation-induced emission switch showing high contrast mehanofluorochromism and solvatofluorochromism: Specifically detects HSO3− in bioimaging studies. Dyes and Pigments, 217, Article 111413. https://doi.org/10.1016/j.dyepig.2023.111413
Journal Article Type | Article |
---|---|
Acceptance Date | May 16, 2023 |
Online Publication Date | Jun 6, 2023 |
Publication Date | 2023-09 |
Deposit Date | Jan 26, 2024 |
Publicly Available Date | Jun 7, 2024 |
Journal | Dyes and Pigments |
Print ISSN | 0143-7208 |
Electronic ISSN | 1873-3743 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 217 |
Article Number | 111413 |
DOI | https://doi.org/10.1016/j.dyepig.2023.111413 |
Public URL | https://durham-repository.worktribe.com/output/2164825 |
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