Skip to main content

Research Repository

Advanced Search

Dr Nicola Fullard's Outputs (11)

Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age (2024)
Journal Article
Fullard, N., Wordsworth, J., Welsh, C., Maltman, V., Bascom, C., Tasseff, R., …Shanley, D. (2024). Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age. Cells, 13(8), Article 659. https://doi.org/10.3390/cells13080659

Skin ageing is defined, in part, by collagen depletion and fragmentation that leads to a loss of mechanical tension. This is currently believed to reflect, in part, the accumulation of senescent cells. We compared the expression of genes and proteins... Read More about Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age.

Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis (2021)
Journal Article
Duffy, L., Henderson, J., Brown, M., Pryzborski, S., Fullard, N., Summa, L., Distler, J. H., Stratton, R., & O’Reilly, S. (2021). Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis. Frontiers in Cell and Developmental Biology, 9, Article 681061. https://doi.org/10.3389/fcell.2021.681061

Objective: Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a BMP antagonist tha... Read More about Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis.

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility (2019)
Book Chapter
Costello, L., Fullard, N., Roger, M., Bradbury, S., Dicolandrea, T., Isfort, R., …Przyborski, S. (2019). Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility. In S. Böttcher-Haberzeth, & T. Biedermann (Eds.), Skin Tissue Engineering (107-122). https://doi.org/10.1007/978-1-4939-9473-1_9

Bioengineering the Microanatomy of Human Skin (2019)
Journal Article
Roger, M., Fullard, N., Costello, L., Bradbury, S., Markiewicz, E., O'Reilly, S., Darling, N., Ritchie, P., Määttä, A., Karakesisoglou, I., Nelson, G., von Zglinicki, T., Dicolandrea, T., Isfort, R., Bascom, C., & Przyborski, S. (2019). Bioengineering the Microanatomy of Human Skin. Journal of Anatomy, 234(4), 438-455. https://doi.org/10.1111/joa.12942

Recreating the structure of human tissues in the laboratory is valuable for fundamental research, testing interventions, and reducing the use of animals. Critical to the use of such technology is the ability to produce tissue models that accurately r... Read More about Bioengineering the Microanatomy of Human Skin.

PyCoTools: a Python toolbox for COPASI (2018)
Journal Article
Welsh, C. M., Fullard, N., Proctor, C. J., Martinez-Guimera, A., Isfort, R. J., Bascom, C. C., Tasseff, R., Przyborski, S. A., & Shanley, D. P. (2018). PyCoTools: a Python toolbox for COPASI. Bioinformatics, 34(21), 3702-3710. https://doi.org/10.1093/bioinformatics/bty409

Motivation COPASI is an open source software package for constructing, simulating and analyzing dynamic models of biochemical networks. COPASI is primarily intended to be used with a graphical user interface but often it is desirable to be able to ac... Read More about PyCoTools: a Python toolbox for COPASI.

MicroRNAs in the skin: role in development, homoeostasis and regeneration (2017)
Journal Article
Horsburgh, S., Fullard, N., Roger, M., Degnan, A., Todryk, S., Przyborski, S., & O’Reilly, S. (2017). MicroRNAs in the skin: role in development, homoeostasis and regeneration. Clinical Science, 131(15), 1923-1940. https://doi.org/10.1042/cs20170039

The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control developm... Read More about MicroRNAs in the skin: role in development, homoeostasis and regeneration.

Systems modelling ageing: from single senescent cells to simple multi-cellular models (2017)
Journal Article
Martinez Guimera, A., Welsh, C., Dalle Pezze, P., Fullard, N., Nelson, G., Roger, M., …Shanley, D. (2017). Systems modelling ageing: from single senescent cells to simple multi-cellular models. Essays in Biochemistry, 61(3), 369-377. https://doi.org/10.1042/ebc20160087

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc... Read More about Systems modelling ageing: from single senescent cells to simple multi-cellular models.

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics (2016)
Journal Article
O’Reilly, S., Ciechomska, M., Fullard, N., Przyborski, S., & van Laar, J. (2016). IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics. Scientific Reports, 6, Article 25066. https://doi.org/10.1038/srep25066

Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that blo... Read More about IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics.

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice (2014)
Journal Article
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., Hewitt, G., Pender, S. L., Fullard, N., Nelson, G., Mann, J., van de Sluis, B., Mann, D. A., & von Zglinicki, T. (2014). Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications, 5(1), https://doi.org/10.1038/ncomms5172

Chronic inflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice. We also... Read More about Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.