Dr Gary Sharples' Outputs (5)

Dissociation of synthetic Holliday junctions by E. coli RecG protein. (1993)
Journal Article
Lloyd, R., & Sharples, G. (1993). Dissociation of synthetic Holliday junctions by E. coli RecG protein. The EMBO Journal, 12(1), 17-22

The RecG protein of Escherichia coli is needed for normal levels of recombination and for repair of DNA damaged by ultraviolet light, mitomycin C and ionizing radiation. The true extent of its involvement in these processes is masked to a large degre... Read More about Dissociation of synthetic Holliday junctions by E. coli RecG protein..

An E. coli RuvC mutant defective in cleavage of synthetic Holliday junctions. (1993)
Journal Article
Sharples, G., & Lloyd, R. (1993). An E. coli RuvC mutant defective in cleavage of synthetic Holliday junctions. Nucleic Acids Research, 21(15), 3359-3364

Escherichia coli RuvC protein is a specific endonuclease that resolves recombination intermediates into viable products. The structural features needed for RuvC activity were investigated by sequencing three ruvC mutations and relating the base pair... Read More about An E. coli RuvC mutant defective in cleavage of synthetic Holliday junctions..

Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations. (1993)
Journal Article
Mandal, T., Mahdi, A., Sharples, G., & Lloyd, R. (1993). Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations. Journal of Bacteriology, 175(14), 4325-4334

The ruvA, ruvB, and ruvC genes of Escherichia coli provide activities that catalyze branch migration and resolution of Holliday junction intermediates in recombination. Mutation of any one of these genes interferes with recombination and reduces the... Read More about Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations..

Location of the Bacillus subtilis sbcD gene downstream of addAB, the analogues of E. coli recBC. (1993)
Journal Article
Sharples, G., & Lloyd, R. (1993). Location of the Bacillus subtilis sbcD gene downstream of addAB, the analogues of E. coli recBC. Nucleic Acids Research, 21(8), https://doi.org/10.1093/nar/21.8.2010

Processing of recombination intermediates by the RecG and RuvAB proteins of Escherichia coli. (1993)
Journal Article
Lloyd, R., & Sharples, G. (1993). Processing of recombination intermediates by the RecG and RuvAB proteins of Escherichia coli. Nucleic Acids Research, 21(8), 1719-1725

The RuvAB, RuvC and RecG proteins of Escherichia coli process intermediates in recombination and DNA repair into mature products. RuvAB and RecG catalyse branch migration of Holliday junctions, while RuvC resolves these structures by nuclease cleavag... Read More about Processing of recombination intermediates by the RecG and RuvAB proteins of Escherichia coli..