All Outputs (6)

Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes (2014)
Journal Article
Mitra, M., Taylor, P., Hutchison, C., McLeish, T., & Chakrabarti, B. (2014). Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes. Journal of the Royal Society. Interface, 11(100), https://doi.org/10.1098/rsif.2014.0706

The epigenetic pathway of a cell as it differentiates from a stem cell state to a mature lineage-committed one has been historically understood in terms of Waddington's landscape, consisting of hills and valleys. The smooth top and valley-strewn bott... Read More about Delayed self-regulation and time-dependent chemical drive leads to novel states in epigenetic landscapes.

All the colours of the rainbow (2014)
Journal Article
Smithson, H. E., Gasper, G. E., & McLeish, T. C. (2014). All the colours of the rainbow. Nature Physics, 10(8), 540-542. https://doi.org/10.1038/nphys3052

Our perception of colour has always been a source of fascination, so it's little wonder that studies of the phenomenon date back hundreds of years. What, though, can modern scientists learn from medieval literature — and how do we go about it?

A medieval multiverse?: Mathematical modelling of the thirteenth century universe of Robert Grosseteste (2014)
Journal Article
Bower, R., McLeish, T., Tanner, B., Smithson, H., Panti, C., Lewis, N., & Gasper, G. (2014). A medieval multiverse?: Mathematical modelling of the thirteenth century universe of Robert Grosseteste. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 470(2167), Article 40025. https://doi.org/10.1098/rspa.2014.0025

In his treatise on light, written about 1225, Robert Grosseteste describes a cosmological model in which the universe is created in a big-bang-like explosion and subsequent condensation. He postulates that the fundamental coupling of light and matter... Read More about A medieval multiverse?: Mathematical modelling of the thirteenth century universe of Robert Grosseteste.

Large amplitude oscillatory shear and Fourier transform rheology analysis of branched polymer melts (2014)
Journal Article
Hoyle, D. M., Auhl, D., Harlen, O., Barroso, V., Wilhelm, M., & McLeish, T. (2014). Large amplitude oscillatory shear and Fourier transform rheology analysis of branched polymer melts. Journal of Rheology, 58(4), https://doi.org/10.1122/1.4881467

In this paper, the predictions of the Pompom constitutive model in medium and large amplitude oscillatory shear (LAOS) are examined using Fourier transform rheology (FTR). FTR is commonly used in combination with small amplitude oscillatory shear to... Read More about Large amplitude oscillatory shear and Fourier transform rheology analysis of branched polymer melts.

The Role of High-Dimensional Diffusive Search, Stabilization, and Frustration in Protein Folding (2014)
Journal Article
Rimratchada, S., McLeish, T., Radford, S., & Paci, E. (2014). The Role of High-Dimensional Diffusive Search, Stabilization, and Frustration in Protein Folding. Biophysical Journal, 106(8), 1729-1740. https://doi.org/10.1016/j.bpj.2014.01.051

Proteins are polymeric molecules with many degrees of conformational freedom whose internal energetic interactions are typically screened to small distances. Therefore, in the high-dimensional conformation space of a protein, the energy landscape is... Read More about The Role of High-Dimensional Diffusive Search, Stabilization, and Frustration in Protein Folding.

Numerical prediction of nonlinear rheology of branched polymer melts (2014)
Journal Article
Das, C., Read, D., Auhl, D., Kapnistos, M., den Doelder, J., Vittorias, I., & McLeish, T. (2014). Numerical prediction of nonlinear rheology of branched polymer melts. Journal of Rheology, 58(3), 737-757. https://doi.org/10.1122/1.4869485

In a recent short communication [Read, D. J. et al., Science 333, 1871 (2011)], we showed that a computational scheme can describe the nonlinear flow properties for a series of industrial low-density polyethylene (LDPE) resins starting from the molec... Read More about Numerical prediction of nonlinear rheology of branched polymer melts.