All Outputs (3)

Metal Preferences and Metallation (2014)
Journal Article
Foster, A. W., Osman, D., & Robinson, N. J. (2014). Metal Preferences and Metallation. Journal of Biological Chemistry, 289(41), 28095-28103. https://doi.org/10.1074/jbc.r114.588145

The metal-binding preferences of most metalloproteins do not match their metal-requirements. Thus, metallation of an estimated 30% of metalloenzymes is aided by metal-delivery systems, with ~25% acquiring pre-assembled metal-cofactors. The remaining... Read More about Metal Preferences and Metallation.

A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae (2014)
Journal Article
Foster, A. W., Dainty, S. J., Patterson, C. J., Pohl, E., Blackburn, H., Wilson, C., …Robinson, N. J. (2014). A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Molecular Microbiology, 93(2), 317-330. https://doi.org/10.1111/mmi.12661

The extreme resistance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two lines of discovery. First, BPQ is shown to form a red (BPQ)2Cu(I) c... Read More about A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae.

Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS (2014)
Journal Article
Foster, A., Pernil, R., Patterson, C., & Robinson, N. (2014). Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS. Molecular Microbiology, 92(4), 797-812. https://doi.org/10.1111/mmi.12594

InrS is a Ni(II)-responsive, CsoR/RcnR-like, DNA-binding transcriptional repressor of the nrsD gene, but the Ni(II) co-ordination sphere of InrS is unlike Ni(II)-RcnR. We show that copper and Zn(II) also bind tightly to InrS and in vitro these ions a... Read More about Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS.