All Outputs (5)

Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives (2014)
Journal Article
Sandford, G., Slater, R., Yufit, D., Howard, J., & Vong, A. (2014). Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives. Journal of Fluorine Chemistry, 167, 91-95. https://doi.org/10.1016/j.jfluchem.2014.05.003

Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems were synthesised by annelation reactions involving highly fluorinated pyridine derivatives and nitrogen and oxygen centred difunctional nucleophiles by sequential regioselective nucl... Read More about Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives.

2-Fluoromalonate esters: fluoroaliphatic building blocks for the life sciences (2014)
Journal Article
Harsanyi, A., & Sandford, G. (2014). 2-Fluoromalonate esters: fluoroaliphatic building blocks for the life sciences. Organic Process Research and Development, 18(8), 981-992. https://doi.org/10.1021/op500141c

The majority of fluorinated pharmaceutical products bear structurally simple fluoro- and trifluoromethyl-aromatic subunits, in part because of the ready availability of a wide range of fluoro and trifluoromethyl aryl derivatives for both drug discove... Read More about 2-Fluoromalonate esters: fluoroaliphatic building blocks for the life sciences.

Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester (2014)
Journal Article
Fisher, C., Harsanyi, A., Sandford, G., Yufit, D., & Howard, J. (2014). Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester. CHIMIA, 68(6), 425-429. https://doi.org/10.2533/chimia.2014.425

A short series of fluorotetrahydroquinolines were synthesised in two steps from diethyl fluoromalonate and appropriate ortho-nitrobenzyl bromide precursors.

Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester (2014)
Journal Article
Harsanyi, A., Sandford, G., Yufit, D., & Howard, J. (2014). Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester. Beilstein Journal of Organic Chemistry, 10, 1213-1219. https://doi.org/10.3762/bjoc.10.119

Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrate... Read More about Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester.

Targeted fluorination of a nonsteroidal anti-inflammatory drug to prolong metabolic half-life (2014)
Journal Article
Shaughnessy, M., Harsanyi, A., Li, J., Bright, T., Murphy, C., & Sandford, G. (2014). Targeted fluorination of a nonsteroidal anti-inflammatory drug to prolong metabolic half-life. ChemMedChem, 9(4), 733-736. https://doi.org/10.1002/cmdc.201300490

In drug design, one way of improving metabolic stability is to introduce fluorine at a metabolically labile site. In the early stages of drug design, identification of such sites is challenging, and a rapid method of assessing the effect of fluorinat... Read More about Targeted fluorination of a nonsteroidal anti-inflammatory drug to prolong metabolic half-life.