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The role of synaptic-like vesicles in control of mechanosensation in peripheral nerve terminals. (2010)
Conference Proceeding
Bewick, G., & Banks, R. (2010). The role of synaptic-like vesicles in control of mechanosensation in peripheral nerve terminals.

Small (50 nm dia), clear vesicles in vertebrate primary mechanosensory nerve terminals were identified by early electron microscopists - at about the same time as in synaptic terminals. This was recognised by Sir Bernard Katz, in Nerve, Muscle and Sy... Read More about The role of synaptic-like vesicles in control of mechanosensation in peripheral nerve terminals..

Whirlin function in proprioceptive mechanotransduction. (2010)
Conference Proceeding
de Nooij, J., Simon, A., Doobar, S., Steel, K., Banks, R., Bewick, G., & Jessell, T. (2010). Whirlin function in proprioceptive mechanotransduction.

Proprioceptive sensory feedback is critical for many aspects of motor control. This form of sensory feedback derives largely from specialized mechanoreceptors located within muscles: the muscle spindle (MS; responsive to changes in muscle length) and... Read More about Whirlin function in proprioceptive mechanotransduction..

Modulation of afferent excitability and reflex responses by phospholipase D-coupled metabotropic glutamate receptors in the peripheral terminals of rat arterial baroreceptors. (2010)
Conference Proceeding
Paton, J., Banks, R., & Bewick, G. (2010). Modulation of afferent excitability and reflex responses by phospholipase D-coupled metabotropic glutamate receptors in the peripheral terminals of rat arterial baroreceptors.

Vertebrate primary mechanosensory nerve terminals contain populations of clear synaptic-like vesicles (SLVs). We have demonstrated glutamate released from SLVs produces autogenic modulation of mechanoreceptor excitability in Ia primary afferent endin... Read More about Modulation of afferent excitability and reflex responses by phospholipase D-coupled metabotropic glutamate receptors in the peripheral terminals of rat arterial baroreceptors..

In lanceolate endings of rat hair follicles the small conductance Ca2+-activated K+ channel SK3 is found mainly in glial cells. (2010)
Conference Proceeding
Shenton, F., Banks, R., & Bewick, G. (2010). In lanceolate endings of rat hair follicles the small conductance Ca2+-activated K+ channel SK3 is found mainly in glial cells.

Autogenic modulation of mechanoreceptor excitability by Ca2+-dependent glutamate release from synaptic-like vesicles (SLVs) has been shown using the muscle spindle as a model (1). The excitability of lanceolate endings of hair follicles may be simila... Read More about In lanceolate endings of rat hair follicles the small conductance Ca2+-activated K+ channel SK3 is found mainly in glial cells..

A role for glutamate in regulating mechanosensory sensitivity: Further evidence from rat muscle spindle primary afferent terminals. (2010)
Conference Proceeding
Simon, A., Banks, R., & Bewick, G. (2010). A role for glutamate in regulating mechanosensory sensitivity: Further evidence from rat muscle spindle primary afferent terminals.

Muscle spindles are proprioceptive sensory organs that constantly report the length and movements of skeletal muscle. The complicated process of mechanotransduction underlying their function is still poorly understood. The stretch-sensitive annulospi... Read More about A role for glutamate in regulating mechanosensory sensitivity: Further evidence from rat muscle spindle primary afferent terminals..

Comparison of gadolinium and FM1-43 as blockers of stretch-evoked firing of rat muscle spindle afferents. (2010)
Conference Proceeding
Watson, S., Aryiku, C., Banks, R., & Bewick, G. (2010). Comparison of gadolinium and FM1-43 as blockers of stretch-evoked firing of rat muscle spindle afferents.

The identity and properties of the mechanotransduction channel within muscle spindles, the proprioceptive sensory organs reporting skeletal muscle length, are poorly understood. We have shown previously that stretch releases glutamate from synaptic-l... Read More about Comparison of gadolinium and FM1-43 as blockers of stretch-evoked firing of rat muscle spindle afferents..

Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. (2010)
Journal Article
Simon, A., Shenton, F., Hunter, I., Banks, R. W., & Bewick, G. S. (2010). Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. The Journal of Physiology, 588(1), 171-185. https://doi.org/10.1113/jphysiol.2009.182683

We investigated whether channels of the epithelial sodium/amiloride-sensitive degenerin(ENaC/DEG) family are a major contributor to mechanosensory transduction in primary mechanosensory afferents, using adult rat muscle spindles as a model system. St... Read More about Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles..