Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes
(2008)
Journal Article
Angell, R., Angell, T., Bamborough, P., Bamford, M., Chung, C., Cockerill, G., …Walker, A. (2008). Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorganic and Medicinal Chemistry Letters, 18(15), 4433-4437. https://doi.org/10.1016/j.bmcl.2008.06.028
The biphenyl amides (BPAs) are a series of p38α MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation, depending on substituents. X-ray, binding, kinetic and cellular data are shown, providing th... Read More about Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.