All Outputs (4)

Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein (2024)
Journal Article
Birkholz, N., Kamata, K., Feussner, M., Wilkinson, M. E., Cuba Samaniego, C., Migur, A., Kimanius, D., Ceelen, M., Went, S. C., Usher, B., Blower, T. R., Brown, C. M., Beisel, C. L., Weinberg, Z., Fagerlund, R. D., Jackson, S. A., & Fineran, P. C. (2024). Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein. Nature, 631(8021), 670-677. https://doi.org/10.1038/s41586-024-07644-1

In all organisms, regulation of gene expression must be adjusted to meet cellular requirements and frequently involves helix–turn–helix (HTH) domain proteins1. For instance, in the arms race between bacteria and bacteriophages, rapid expression of ph... Read More about Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein.

Editorial- Launching Enhancing Learning & Teaching in Higher Education (ELTHE): a place to publish and share your own scholarly work and teaching innovations. (2024)
Journal Article
Roger, M., & Nolan, S. (2024). Editorial- Launching Enhancing Learning & Teaching in Higher Education (ELTHE): a place to publish and share your own scholarly work and teaching innovations. Enhancing Teaching and Learning in Higher Education, 1, 1-3. https://doi.org/10.62512/etlhe.13

Welcome to the first edition of Enhancing Teaching and Learning in Higher Education (ELTHE). ETLHE offers an opportunity for those involved in universitylearning and teaching to disseminate their practice. It aims to publish accounts of scho... Read More about Editorial- Launching Enhancing Learning & Teaching in Higher Education (ELTHE): a place to publish and share your own scholarly work and teaching innovations..

Multi-layered genome defences in bacteria (2024)
Journal Article
Agapov, A., Baker, K., Bedekar, P., Bhatia, R., Blower, T. R., Brockhurst, M. A., …Wright, R. (2024). Multi-layered genome defences in bacteria. Current Opinion in Microbiology, 78, Article 102436. https://doi.org/10.1016/j.mib.2024.102436

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Not... Read More about Multi-layered genome defences in bacteria.

Diverse Durham collection phages demonstrate complex BREX defence responses (2023)
Journal Article
Kelly, A., Went, S. C., Mariano, G., Shaw, L. P., Picton, D. M., Duffner, S. J., Coates, I., Herdman-Grant, R., Gordeeva, J., Drobiazko, A., Isaev, A., Lee, Y.-J., Luyten, Y., Morgan, R. D., Weigele, P., Severinov, K., Wenner, N., Hinton, J. C., & Blower, T. R. (2023). Diverse Durham collection phages demonstrate complex BREX defence responses. Applied and Environmental Microbiology, https://doi.org/10.1128/aem.00623-23

Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of 1025 per second. The ability of phages to reduce bacterial populations makes them attractive alternative antibacterials for use in combating the rise in antimicro... Read More about Diverse Durham collection phages demonstrate complex BREX defence responses.