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Multi-layered genome defences in bacteria

Agapov, Aleksei; Baker, Kate; Bedekar, Paritosh; Bhatia, Rama; Blower, Tim R.; Brockhurst, Michael A.; Brown, Cooper; Chong, Charlotte; Fothergill, Joanne L.; Graham, Shirley; Hall, James P. J.; Maestri, Alice; McQuarrie, Stuart; Olina, Anna; Pagliara, Stefano; Recker, Mario; Richmond, Anna; Shaw, Steven J.; Szczelkun, Mark D.; Taylor, Tiffany B.; van Houte, Stineke; Went, Sam C.; Westra, Edze R.; White, Malcolm F.; Wright, Rosanna

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Authors

Aleksei Agapov

Kate Baker

Paritosh Bedekar

Rama Bhatia

Michael A. Brockhurst

Cooper Brown

Charlotte Chong

Joanne L. Fothergill

Shirley Graham

James P. J. Hall

Alice Maestri

Stuart McQuarrie

Anna Olina

Stefano Pagliara

Mario Recker

Anna Richmond

Steven J. Shaw

Mark D. Szczelkun

Tiffany B. Taylor

Stineke van Houte

Samuel Went samuel.c.went@durham.ac.uk
Post Doctoral Research Associate

Edze R. Westra

Malcolm F. White

Rosanna Wright



Abstract

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

Citation

Agapov, A., Baker, K., Bedekar, P., Bhatia, R., Blower, T. R., Brockhurst, M. A., …Wright, R. (2024). Multi-layered genome defences in bacteria. Current Opinion in Microbiology, 78, Article 102436. https://doi.org/10.1016/j.mib.2024.102436

Journal Article Type Article
Acceptance Date Jan 23, 2024
Online Publication Date Feb 17, 2024
Publication Date 2024-04
Deposit Date Feb 9, 2024
Publicly Available Date Feb 23, 2024
Journal Current Opinion in Microbiology
Print ISSN 1369-5274
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 78
Article Number 102436
DOI https://doi.org/10.1016/j.mib.2024.102436
Public URL https://durham-repository.worktribe.com/output/2231261

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