Aleksei Agapov
Multi-layered genome defences in bacteria
Agapov, Aleksei; Baker, Kate; Bedekar, Paritosh; Bhatia, Rama; Blower, Tim R.; Brockhurst, Michael A.; Brown, Cooper; Chong, Charlotte; Fothergill, Joanne L.; Graham, Shirley; Hall, James P. J.; Maestri, Alice; McQuarrie, Stuart; Olina, Anna; Pagliara, Stefano; Recker, Mario; Richmond, Anna; Shaw, Steven J.; Szczelkun, Mark D.; Taylor, Tiffany B.; van Houte, Stineke; Went, Sam C.; Westra, Edze R.; White, Malcolm F.; Wright, Rosanna
Authors
Kate Baker
Paritosh Bedekar
Rama Bhatia
Professor Tim Blower timothy.blower@durham.ac.uk
Professor
Michael A. Brockhurst
Cooper Brown
Charlotte Chong
Joanne L. Fothergill
Shirley Graham
James P. J. Hall
Alice Maestri
Stuart McQuarrie
Anna Olina
Stefano Pagliara
Mario Recker
Anna Richmond
Steven J. Shaw
Mark D. Szczelkun
Tiffany B. Taylor
Stineke van Houte
Samuel Went samuel.c.went@durham.ac.uk
Post Doctoral Research Associate
Edze R. Westra
Malcolm F. White
Rosanna Wright
Abstract
Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.
Citation
Agapov, A., Baker, K., Bedekar, P., Bhatia, R., Blower, T. R., Brockhurst, M. A., …Wright, R. (2024). Multi-layered genome defences in bacteria. Current Opinion in Microbiology, 78, Article 102436. https://doi.org/10.1016/j.mib.2024.102436
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 23, 2024 |
Online Publication Date | Feb 17, 2024 |
Publication Date | 2024-04 |
Deposit Date | Feb 9, 2024 |
Publicly Available Date | Feb 23, 2024 |
Journal | Current Opinion in Microbiology |
Print ISSN | 1369-5274 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 78 |
Article Number | 102436 |
DOI | https://doi.org/10.1016/j.mib.2024.102436 |
Public URL | https://durham-repository.worktribe.com/output/2231261 |
Files
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Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
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