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Targeted pH switched europium complexes monitoring receptor internalisation in living cells (2021)
Journal Article
Fradgley, J. D., Starck, M., Laget, M., Bourrier, E., Dupuis, E., Lamarque, L., Trinquet, E., Zwier, J. M., & Parker, D. (2021). Targeted pH switched europium complexes monitoring receptor internalisation in living cells. Chemical Communications, 57(47), 5814-5817. https://doi.org/10.1039/d1cc01029h

We report the design and evaluation of pH responsive luminescent europium(III) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to m... Read More about Targeted pH switched europium complexes monitoring receptor internalisation in living cells.

Material Responses to the Great Depression in Northeast England (2021)
Journal Article
Petts, D., O’Donnell, R., & Armstrong, K. (2021). Material Responses to the Great Depression in Northeast England. International Journal of Historical Archaeology, 25(4), 1165-1193. https://doi.org/10.1007/s10761-021-00595-7

The Great Depression of the 1920s and 1930s was a global economic crisis, yet to understand its impacts in material terms, it is necessary to recognize that they were situated within specific local and regional contexts. This article, drawing on the... Read More about Material Responses to the Great Depression in Northeast England.

Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field (2021)
Journal Article
Fradgley, J. D., Frawley, A. T., Pal, R., & Parker, D. (2021). Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field. Physical Chemistry Chemical Physics, 23(19), 11479-11487. https://doi.org/10.1039/d1cp01686e

Examination of total emission and circularly polarised luminescence (CPL) spectra of three 9-coordinate Eu(III) complexes with well-defined speciation shows that the ligand fields of these C3 symmetric complexes are extremely sensitive to solvent pol... Read More about Striking solvent dependence of total emission and circularly polarised luminescence in coordinatively saturated chiral europium complexes: solvation significantly perturbs the ligand field.

Early medieval County Durham (2021)
Book Chapter
Petts, D. (2021). Early medieval County Durham. In M. Roberts, N. Pevsner, & E. Williamson (Eds.), County Durham (15-20). Yale University Press

Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing blood-stream infection in Malawi (2021)
Journal Article
Rodwell, E., Wenner, N., Pulford, C., Cai, Y., Bowers-Barnard, A., Beckett, A., …Perez-Sepulveda, B. (2021). Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing blood-stream infection in Malawi. Viruses, 13(3), Article 478. https://doi.org/10.3390/v13030478

In recent years, novel lineages of invasive non-typhoidal Salmonella (iNTS) serovars Typhimurium and Enteritidis have been identified in patients with bloodstream infection in sub-Saharan Africa. Here, we isolated and characterised 32 phages capable... Read More about Isolation and characterisation of bacteriophages with activity against invasive non-typhoidal Salmonella causing blood-stream infection in Malawi.

Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse (2021)
Journal Article
Grebby, S., Sowter, A., Gluyas, J., Toll, D., Gee, D., Athab, A., & Girindran, R. (2021). Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse. Communications Earth & Environment, 2, Article 2. https://doi.org/10.1038/s43247-020-00079-2

Catastrophic failure of a tailings dam at an iron ore mine complex in Brumadinho, Brazil, on 25th January 2019 released 11.7 million m3 of tailings downstream. Although reportedly monitored using an array of geotechnical techniques, the collapse occu... Read More about Advanced analysis of satellite data reveals ground deformation precursors to the Brumadinho Tailings Dam collapse.

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging (2021)
Journal Article
Zhang, Y., Ma, X., Chau, H., Thor, W., Jiang, L., Zha, S., …Wong, K. (2021). Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging. ACS Applied Nano Material, 4(1), 271-278. https://doi.org/10.1021/acsanm.0c02597

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lant... Read More about Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging.

Weather-driven deterioration processes affecting the performance of embankment slopes (2020)
Journal Article
Stirling, R., Toll, D., Glendinning, S., Helm, P., Yildiz, A., Hughes, P., & Asquith, J. (2021). Weather-driven deterioration processes affecting the performance of embankment slopes. Géotechnique, 71(11), 957-969. https://doi.org/10.1680/jgeot.19.sip.038

Deterioration of earthworks and the resultant implications for serviceability and increased occurrence of failures have a significant negative impact on transport networks both in the UK and internationally. There is evidence in the field that deteri... Read More about Weather-driven deterioration processes affecting the performance of embankment slopes.

Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells (2020)
Journal Article
Starck, M., Fradgley, J. D., Pal, R., Zwier, J. M., Lamarque, L., & Parker, D. (2021). Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells. Chemistry - A European Journal, 27(2), 766-777. https://doi.org/10.1002/chem.202003992

A set of four luminescent Eu(III) complexes bearing an extended aryl‐alkynylpyridine chromophore has been studied, showing very different pH‐dependent behaviour in their absorption and emission spectral response. For two complexes with p K a values o... Read More about Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells.

Field monitoring of soil-moisture to understand the hydrological response of a road-cut slope (2020)
Book Chapter
Pradhan, S., Toll, D., Rosser, N., & Brain, M. (2020). Field monitoring of soil-moisture to understand the hydrological response of a road-cut slope. In R. Cardoso, C. Jommi, & E. Romero (Eds.), 4th European Conference on Unsaturated Soils (E-UNSAT 2020). EDP Sciences. https://doi.org/10.1051/e3sconf/202019501029

Rainfall and slope-cutting for road construction are two key landslide causative factors in Nepal, but how they interact to cause failures is poorly understood. To improve understanding of the effects of cut slopes during rainfall, geotechnical inves... Read More about Field monitoring of soil-moisture to understand the hydrological response of a road-cut slope.

Cellular localisation of structurally diverse diphenylacetylene fluorophores (2020)
Journal Article
Chisholm, D. R., Hughes, J. G., Blacker, T. S., Humann, R., Adams, C., Callaghan, D., …Whiting, A. (2020). Cellular localisation of structurally diverse diphenylacetylene fluorophores. Organic and Biomolecular Chemistry, 18(45), 9231-9245. https://doi.org/10.1039/d0ob01153c

Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be difficult to anticipate the effect that changing chemical structure can have on cellular loc... Read More about Cellular localisation of structurally diverse diphenylacetylene fluorophores.

How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior (2020)
Journal Article
Parker, D., Suturina, E. A., Kuprov, I., & Chilton, N. F. (2020). How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior. Accounts of Chemical Research, 53(8), 1520-1534. https://doi.org/10.1021/acs.accounts.0c00275

Complexes of lanthanide(III) ions are being actively studied because of their unique ground and excited state properties and the associated optical and magnetic behavior. In particular, they are used as emissive probes in optical spectroscopy and mic... Read More about How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior.

Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy (2020)
Journal Article
Gala De Pablo, J., Chisholm, D., Ambler, C., Peyman, S., Whiting, A., & Evans, S. (2020). Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy. Analyst, 145(17), 5878-5888. https://doi.org/10.1039/d0an01023e

Raman spectroscopy has been used to observe uptake, metabolism and response of single-cells to drugs. Photodynamic therapy is based on the use of light, a photosensitiser and oxygen to destroy tumour tissue. Here, we used single-cell Raman spectrosco... Read More about Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy.

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity (2020)
Journal Article
Cross, J., Blower, T., Kingdon, A., Pal, R., Picton, D., & Walton, J. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules, 25(10), Article 2383. https://doi.org/10.3390/molecules25102383

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms m... Read More about Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.

Experimental, numerical and field study investigating a heritage structure collapse after the 2015 Gorkha earthquake (2020)
Journal Article
Kumar, A., Hughes, P. N., Sarhosis, V., Toll, D., Wilkinson, S., Coningham, R., …Maskey, P. N. (2020). Experimental, numerical and field study investigating a heritage structure collapse after the 2015 Gorkha earthquake. Natural Hazards, 101(1), 231-253. https://doi.org/10.1007/s11069-020-03871-7

This paper presents an investigation of the collapse of a 325-year-old multi-tiered heritage temple during the 2015 Gorkha earthquake in Kathmandu, Nepal. The research comprises a reconnaissance survey followed by a geotechnical investigation and num... Read More about Experimental, numerical and field study investigating a heritage structure collapse after the 2015 Gorkha earthquake.

Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7 (2020)
Journal Article
Ye, F., Kotta-Loizou, I., Jovanovic, M., Liu, X., Dryden, D. T., Buck, M., & Zhang, X. (2020). Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7. eLife, 9, Article e52125. https://doi.org/10.7554/elife.52125

Bacteriophage T7 infects Escherichia coli and evades the host restriction/modification system. The Ocr protein of T7 was shown to exist as a dimer mimicking DNA and to bind to host restriction enzymes, thus preventing the degradation of the viral gen... Read More about Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7.

Identifying archaeological evidence of past earthquakes in a contemporary disaster scenario: Case-studies of damage, resilience and risk reduction from the 2015 Gorkha Earthquake and past seismic events within the Kathmandu Valley UNESCO World Heritage Property (Nepal) (2019)
Journal Article
Davis, C., Coningham, R., Acharya, K., Kunwar, R., Forlin, P., Weise, K., …Schmidt, A. (2020). Identifying archaeological evidence of past earthquakes in a contemporary disaster scenario: Case-studies of damage, resilience and risk reduction from the 2015 Gorkha Earthquake and past seismic events within the Kathmandu Valley UNESCO World Heritage Property (Nepal). Journal of Seismology, 24(4), 729-751. https://doi.org/10.1007/s10950-019-09890-7

The 2015 Gorkha Earthquake was a humanitarian disaster but also a cultural catastrophe that damaged and destroyed historic monuments across Nepal, including those within the Kathmandu Valley UNESCO World Heritage Property. In the rush to rebuild, tra... Read More about Identifying archaeological evidence of past earthquakes in a contemporary disaster scenario: Case-studies of damage, resilience and risk reduction from the 2015 Gorkha Earthquake and past seismic events within the Kathmandu Valley UNESCO World Heritage Property (Nepal).